The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

N-Linked Glycosylation Is Required for Transferrin-Induced Stabilization of Transferrin Receptor 2, but Not for Transferrin Binding or Trafficking to the Cell Surface

(2013) Ningning Zhao et al.   BIOCHEMISTRY

TFR2-related hereditary hemochromatosis as a frequent cause of primary iron overload in patients from Central-Southern Italy

(2013) Francesca Clementina Radio et al.   BLOOD CELLS MOLECULES AND DISEASES

Iranian hereditary hemochromatosis patients: Baseline characteristics, laboratory data and gene mutations

(2013) Farhad Zamani et al.   MEDICAL SCIENCE MONITOR

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

(2013) Caroline A. Enns et al.   PLoS One

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

(2012) Paul J. Schmidt et al.   AMERICAN JOURNAL OF HEMATOLOGY

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

(2012) Maja Vujić Spasić et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

(2011) Elena Corradini et al.   GASTROENTEROLOGY

Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice

(2011) T. B. Bartnikas et al.   HAEMATOLOGICA

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice

(2010) T. B. Bartnikas et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

(2010) J. Gao et al.   BLOOD

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-  and Tfr2-  isoforms in different tissues

(2010) A. Roetto et al.   BLOOD

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

(2010) D. Girelli et al.   HAEMATOLOGICA

ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin

(2010) Ningning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

(2009) K. Mleczko-Sanecka et al.   BLOOD

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis

(2009) Elena Corradini et al.   GASTROENTEROLOGY

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

(2009) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Transferrin-Directed Internalization and Cycling of Transferrin Receptor 2

(2009) Juxing Chen et al.   TRAFFIC

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

(2008) J. Truksa et al.   BLOOD

Serum hepcidin levels are innately low inHFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels

(2008) Boukje A. C. van Dijk et al.   BRITISH JOURNAL OF HAEMATOLOGY

Early-onset haemochromatosis caused by a novel combination of TFR2 mutations(p.R396X/c.1538-2 A>G) in a woman of Italian descent

(2008) V. Gerolami et al.   HAEMATOLOGICA

New TFR2 mutations in young Italian patients with hemochromatosis

(2008) G. Biasiotto et al.   HAEMATOLOGICA

Hepcidin: from discovery to differential diagnosis

(2008) E. H.J.M. Kemna et al.   HAEMATOLOGICA

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

(2008) Maria Vittoria Verga Falzacappa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis

(2007) Daniel F. Wallace et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

(2007) Erika V. Valore et al.   BLOOD CELLS MOLECULES AND DISEASES