Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice

(2012) Qi Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression

(2012) David M. Frazer et al.   BRITISH JOURNAL OF HAEMATOLOGY

BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system

(2012) Karen Ruschke et al.   CELL AND TISSUE RESEARCH

Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration

(2012) Nian-Ling Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors

(2011) Kai Schledzewski et al.   JOURNAL OF CLINICAL INVESTIGATION

The Molecular Pathogenesis of Hereditary Hemochromatosis

(2011) Jodie Babitt et al.   SEMINARS IN LIVER DISEASE

Hepcidin and Disorders of Iron Metabolism

(2010) Tomas Ganz et al.   Annual Review of Medicine

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

(2010) K. E. Finberg et al.   BLOOD

Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice

(2010) T. B. Bartnikas et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

(2010) L. A. Cohen et al.   BLOOD

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Multiple Endocrine Regulation by Bone Morphogenetic Protein System

(2010) Fumio OTSUKA   ENDOCRINE JOURNAL

The Role of Hepatocyte Hemojuvelin in the Regulation of Bone Morphogenic Protein-6 and Hepcidin Expressionin Vivo

(2010) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression

(2009) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

(2008) Shigang Xiong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Regulation of iron acquisition and storage: consequences for iron-linked disorders

(2007) Ivana De Domenico et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY