期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 34, 期 3, 页码 280-292出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2013.879711
关键词
ATG5; autophagy; lupus; T cell
类别
资金
- Major State Basic Research Development Program of China (973 program) [2012CB517700]
- National Natural Science Foundation of China [81200524]
- Research Fund of Beijing Municipal Science and Technology for the Outstanding PhD Program [20121000110]
- Foundation of Ministry of Education of China [20120001120008]
- Natural Science Fund of China to the Innovation Research Group [81021004]
Aberrations of both innate immunity and adaptive immunity in genetically predisposed individuals evoked by environmental factors are suggested to be implicated in pathophysiological processes of systemic lupus erythematosus (SLE). Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded by the lysosome, has been recently demonstrated to be involved in multiple cytoplasmic homeostatic progresses and interact with nearly all parts of the innate and adaptive immune system. More recently, some lines of evidence from genetic, cell biology and model animal studies also suggests a pivotal role of autophagy in mediating the occurrence and development of SLE. We discuss and synthesize studies that have begun to demonstrate how autophagy cause and/or promote autoimmunity in SLE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据