A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia

Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing

(2010) Stefan Taudien et al.   BMC GENOMICS

Human β-defensin 3 has immunosuppressive activityin vitroandin vivo

(2010) Fiona Semple et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Both copy number and sequence variations affect expression of human DEFB4

(2010) M Groth et al.   GENES AND IMMUNITY

Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease

(2010) Marian C. Aldhous et al.   HUMAN MOLECULAR GENETICS

The evolution of gene duplications: classifying and distinguishing between models

(2010) Hideki Innan et al.   NATURE REVIEWS GENETICS

Dosage Sensitivity Shapes the Evolution of Copy-Number Varied Regions

(2010) Benjamin Schuster-Böckler et al.   PLoS One

Diversity of Human Copy Number Variation and Multicopy Genes

(2010) Peter H. Sudmant et al.   SCIENCE

Psoriasis genetics: breaking the barrier

(2010) Elisha D.O. Roberson et al.   TRENDS IN GENETICS

Association of Higher DEFB4 Genomic Copy Number With Crohn's Disease

(2009) Robert W Bentley et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

An integrated approach for measuring copy number variation at theFCGR3(CD16) locus

(2009) Edward J. Hollox et al.   HUMAN MUTATION

Genomic copy number variation, human health, and disease

(2009) Louise V Wain et al.   LANCET

A burst of segmental duplications in the genome of the African great ape ancestor

(2009) Tomas Marques-Bonet et al.   NATURE

Origins and functional impact of copy number variation in the human genome

(2009) Donald F. Conrad et al.   NATURE

β-Defensin-2 Protein Is a Serum Biomarker for Disease Activity in Psoriasis and Reaches Biologically Relevant Concentrations in Lesional Skin

(2009) Patrick A. M. Jansen et al.   PLoS One

Allelic recombination between distinct genomic locations generates copy number diversity in human β-defensins

(2009) Suhaili Abu Bakar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive Evolution of UGT2B17 Copy-Number Variation

(2008) Yali Xue et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Extensive Copy-Number Variation of the Human Olfactory Receptor Gene Family

(2008) Janet M. Young et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Directional and balancing selection in human beta-defensins

(2008) Edward J Hollox et al.   BMC EVOLUTIONARY BIOLOGY

Reduced purifying selection prevails over positive selection in human copy number variant evolution

(2008) D.-Q. Nguyen et al.   GENOME RESEARCH

Copy number variation and evolution in humans and chimpanzees

(2008) G. H. Perry et al.   GENOME RESEARCH

Defensins and the dynamic genome: What we can learn from structural variation at human chromosome band 8p23.1

(2008) E. J. Hollox et al.   GENOME RESEARCH

High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes

(2008) Marco Groth et al.   HUMAN MUTATION

Integrated detection and population-genetic analysis of SNPs and copy number variation

(2008) Steven A McCarroll et al.   NATURE GENETICS

Natural Selection Shapes Genome-Wide Patterns of Copy-Number Polymorphism in Drosophila melanogaster

(2008) J. J. Emerson et al.   SCIENCE

Genetic Variants of the Copy Number Polymorphic β-Defensin Locus Are Associated with Sporadic Prostate Cancer

(2008) Klaus Huse et al.   TUMOR BIOLOGY