Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications
出版年份 2015 全文链接
标题
Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications
作者
关键词
Zinc, Glycaemic Control, Zinc Supplementation, Zinc Transporter, Inhibit Glucagon Secretion
出版物
DARU-Journal of Pharmaceutical Sciences
Volume 23, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-09-17
DOI
10.1186/s40199-015-0127-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- TRPM2-mediated intracellular Zn2+release triggers pancreatic β-cell death
- (2015) Paul T. Manna et al. BIOCHEMICAL JOURNAL
- Effect and mechanisms of zinc supplementation in protecting against diabetic cardiomyopathy in a rat model of type 2 diabetes
- (2015) Ying Lu et al. Bosnian Journal of Basic Medical Sciences
- Zinc inhibits glycation induced structural, functional modifications in albumin and protects erythrocytes from glycated albumin toxicity
- (2015) Rashmi Tupe et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Effect of zinc on high glucose-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells
- (2015) XIULI ZHANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells
- (2015) Ying Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Zinc Finger Protein 407 (ZFP407) Regulates Insulin-stimulated Glucose Uptake and Glucose Transporter 4 (Glut4) mRNA
- (2015) David A. Buchner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells
- (2015) MINGYUE XIONG et al. Molecular Medicine Reports
- Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis
- (2015) Priyanga Ranasinghe et al. Nutrition & Metabolism
- Zinc-α2-Glycoprotein Modulates AKT-Dependent Insulin Signaling in Human Adipocytes by Activation of the PP2A Phosphatase
- (2015) Victòria Ceperuelo-Mallafré et al. PLoS One
- Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein
- (2015) Tingting Liang et al. TOXICOLOGY LETTERS
- Zip4 Mediated Zinc Influx Stimulates Insulin Secretion in Pancreatic Beta Cells
- (2015) Alexandre B. Hardy et al. PLoS One
- Protection against T1DM-Induced Bone Loss by Zinc Supplementation: Biomechanical, Histomorphometric, and Molecular Analyses in STZ-Induced Diabetic Rats
- (2015) Raul Hernandes Bortolin et al. PLoS One
- Deciphering metal-induced oxidative damages on glycated albumin structure and function
- (2014) Jennifer Baraka-Vidot et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Zinc Modulates High Glucose-Induced Apoptosis by Suppressing Oxidative Stress in Renal Tubular Epithelial Cells
- (2014) Xiuli Zhang et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Zinc Supplementation Alleviates Diabetic Peripheral Neuropathy by Inhibiting Oxidative Stress and Upregulating Metallothionein in Peripheral Nerves of Diabetic Rats
- (2014) Fangyao liu et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Zinc Oxide Nanoparticles Reduce Apoptosis and Oxidative Stress Values in Isolated Rat Pancreatic Islets
- (2014) Parisa Shoae-Hagh et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells
- (2014) Philipp A. Gerber et al. DIABETOLOGIA
- TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus
- (2014) Anna Chu et al. Genes and Nutrition
- Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats
- (2014) Ali Alkaladi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Critical Role for the Neural Zinc Factor ST18 in Pancreatic β-Cell Apoptosis
- (2014) Cyndi Henry et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Zinc is essential for the transcription function of Nrf2 in human renal tubule cellsin vitroand mouse kidneyin vivounder the diabetic condition
- (2014) Bing Li et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Toxicology of ZnO and TiO2nanoparticles on hepatocytes: Impact on metabolism and bioenergetics
- (2014) Celine Filippi et al. Nanotoxicology
- Subcutaneous adipose tissue zinc-α2-glycoprotein is associated with adipose tissue and whole-body insulin sensitivity
- (2014) Miroslav Balaz et al. Obesity
- Insulin Production Hampered by Intermittent Hypoxia via Impaired Zinc Homeostasis
- (2014) Eung-Kwon Pae et al. PLoS One
- Zinc-chelated Vitamin C Stimulates Adipogenesis of 3T3-L1 Cells
- (2013) Chiranjit Ghosh et al. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
- Development of New Zinc Dithiosemicarbazone Complex for Use as Oral Antidiabetic Agent
- (2013) Saori Kadowaki et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2
- (2013) Xiao Miao et al. Cardiovascular Diabetology
- Inhibitory effect of zinc on glucose-stimulated zinc/insulin secretion in an insulin-secreting β-cell line
- (2013) Kira G. Slepchenko et al. EXPERIMENTAL PHYSIOLOGY
- The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance
- (2013) Motoyuki Tamaki et al. JOURNAL OF CLINICAL INVESTIGATION
- Zinc Deficiency Augments Leptin Production and Exacerbates Macrophage Infiltration into Adipose Tissue in Mice Fed a High-Fat Diet
- (2013) Ming-Jie Liu et al. JOURNAL OF NUTRITION
- Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats
- (2013) Rinku D Umrani et al. Nanomedicine
- Achievement of Goals in U.S. Diabetes Care, 1999–2010
- (2013) Mohammed K. Ali et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells
- (2013) Stephen A. Myers et al. PLoS One
- Zinc Supplementation Attenuates Metallothionein and Oxidative Stress Changes in Kidney of Streptozotocin-Induced Diabetic Rats
- (2012) Dervis Özcelik et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- ZnT8 and type 1 diabetes [Review]
- (2012) Eiji Kawasaki ENDOCRINE JOURNAL
- Design, synthesis and characterization of zinc-3 hydroxy flavone, a novel zinc metallo complex for the treatment of experimental diabetes in rats
- (2012) Kalavakunda Vijayaraghavan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Regulation and functional effects of ZNT8 in human pancreatic islets
- (2012) Bruno Lefebvre et al. JOURNAL OF ENDOCRINOLOGY
- Development of a novel antidiabetic zinc complex with an organoselenium ligand at the lowest dosage in KK-Ay mice
- (2012) Shigeyuki Fujimoto et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in Wistar rats
- (2012) Xue Wang et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background
- (2012) Lynley D. Pound et al. PLoS One
- Protective Antioxidant and Antiapoptotic Effects of ZnCl2 in Rat Pancreatic Islets Cultured in Low and High Glucose Concentrations
- (2012) Jessica Duprez et al. PLoS One
- Inhibitory effect of Zn2+ on α-glucosidase: Inhibition kinetics and molecular dynamics simulation
- (2012) Yan-Fei Zeng et al. PROCESS BIOCHEMISTRY
- Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis
- (2012) R Jayawardena et al. Diabetology & Metabolic Syndrome
- Antioxidant potential of zinc-flavonol complex studied in streptozotocin-diabetic rats (锌黄酮醇复合物在链脲霉素-糖尿病大鼠中的抗氧化作用)
- (2012) Kalavakunda Vijayaraghavan et al. Journal of Diabetes
- Supplementation of zinc mitigates the altered uptake and turnover of 65Zn in liver and whole body of diabetic rats
- (2011) Ashima Pathak et al. BIOMETALS
- Cellular Mechanism of Zinc–Hinokitiol Complexes in Diabetes Mellitus
- (2011) Yuki Naito et al. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
- Oral Administration of Bis(aspirinato)zinc(II) Complex Ameliorates Hyperglycemia and Metabolic Syndrome-Like Disorders in Spontaneously Diabetic KK-Ay Mice: Structure–Activity Relationship on Zinc–Salicylate Complexes
- (2011) Yutaka Yoshikawa et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Patient adherence to medication requirements for therapy of type 2 diabetes
- (2011) C. J. Bailey et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Glucose Regulates Free Cytosolic Zn2+Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells
- (2011) Elisa A. Bellomo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Investigation of the insulin-like properties of zinc(II) complexes of 3-hydroxy-4-pyridinones: Identification of a compound with glucose lowering effect in STZ-induced type I diabetic animals
- (2011) Tânia Moniz et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Effects of Zn(ii) complex with vitamins C and U, and carnitine on metabolic syndrome model rats
- (2011) Kinuyo Matsumoto et al. Metallomics
- In Vitro Transdifferentiation of HepG2 Cells to Pancreatic-Like Cells by CCl4, d-Galactosamine, and ZnCl2
- (2011) Yoshiya Kanoh et al. PANCREAS
- The adipokine zinc-α2-glycoprotein activates AMP kinase in human primary skeletal muscle cells
- (2011) Kristin Eckardt et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Oxidative Stress and Diabetic Complications
- (2010) Ferdinando Giacco et al. CIRCULATION RESEARCH
- Zinc, zinc transporters and diabetes
- (2010) J. Rungby DIABETOLOGIA
- Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
- (2010) N. Wijesekara et al. DIABETOLOGIA
- Effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar, insulin, apoprotein B and apoprotein A-I in patients with type I diabetes
- (2010) Farzad Shidfar et al. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
- Studies on the anti-obesity activity of zinc-α2-glycoprotein in the rat
- (2010) S T Russell et al. INTERNATIONAL JOURNAL OF OBESITY
- Role of Zinc in Human Islet Amyloid Polypeptide Aggregation
- (2010) Jeffrey R. Brender et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Metallo–allixinate complexes with anti-diabetic and anti-metabolic syndrome activities
- (2010) Hiromu Sakurai et al. Metallomics
- TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells
- (2010) Thomas F. J. Wagner et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion
- (2009) Lynley D. Pound et al. BIOCHEMICAL JOURNAL
- Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes
- (2009) Yutaka Yoshikawa et al. BIOCHIMIE
- Zn2+-transporter-8: A dual role in diabetes
- (2009) Dimitry A. Chistiakov et al. BIOFACTORS
- ATP-Sensitive K+ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation
- (2009) M. Slucca et al. DIABETES
- Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants
- (2009) T. J. Nicolson et al. DIABETES
- Glycaemic goals in patients with type 2 diabetes: current status, challenges and recent advances
- (2009) K. Khunti et al. DIABETES OBESITY & METABOLISM
- Zinc supplementation partially prevents renal pathological changes in diabetic rats☆
- (2009) Yunan Tang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia-induced phosphatidylserine externalization and reversed by metformin
- (2009) Jennifer A. Meyer et al. Molecular BioSystems
- Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion
- (2009) Yi Fu et al. PLoS One
- SLC30A3 Responds to Glucose- and Zinc Variations in ß-Cells and Is Critical for Insulin Production and In Vivo Glucose-Metabolism During ß-Cell Stress
- (2009) Kamille Smidt et al. PLoS One
- Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
- (2009) K. Lemaire et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis, Characterization and Hypoglycemic Activity of Zn(II), Cd(II) and Hg(II) Complexes with Glibenclamide
- (2008) Khalid Rasheed et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes
- (2008) Midori Nishide et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study
- (2008) F. Álvarez Guisasola et al. DIABETES OBESITY & METABOLISM
- Investigation of Transport Mechanisms and Regulation of Intracellular Zn2+in Pancreatic α-Cells
- (2008) Armen V. Gyulkhandanyan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular mechanism of antidiabetic zinc–allixin complexes: regulations of glucose utilization and lipid metabolism
- (2008) Akihiro Nakayama et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- A Zinc(II)/Poly(γ-glutamic acid) Complex as an Oral Therapeutic for the Treatment of Type-2 Diabetic KKAyMice
- (2008) Subarna Karmaker et al. MACROMOLECULAR BIOSCIENCE
- Population Causes and Consequences of Leading Chronic Diseases: A Comparative Analysis of Prevailing Explanations
- (2008) DAVID STUCKLER MILBANK QUARTERLY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now