Article
Biochemistry & Molecular Biology
Rashmi S. Tupe, Nilima Bangar, Akib Nisar, Amruta Kulkarni, Neena Sankhe, Rohan Chauhan, Nidhi Mistry, Shamim Shaikh
Summary: Piperine demonstrates preventive, protective, and therapeutic effects on albumin glycation, while also safeguarding red blood cells from oxidative damage induced by glycated albumin.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lezhen Dong, Yunzhen Zhang, Ying Li, Yahui Liu, Qin Chen, Lingyi Liu, Mohamed Farag, Lianliang Liu
Summary: This study found that oat phenolic acids can inhibit the formation of AGEs and POPs in dairy products, and protect whey protein structure. The inhibitory effects of oat phenolic acids on AGEs and POPs may be related to the binding of key amino acid residues in whey proteins, the inhibitory role of early fructosamine, and the trapping of reactive α-dicarbonyl groups to form adducts.
Article
Biochemistry & Molecular Biology
Akib Nisar, Devangi K. Ajabia, Sanskruthi B. Agrawal, Sanjana Varma, Bhushan P. Chaudhari, Rashmi S. Tupe
Summary: The interaction and structural modifications of bovine serum albumin (BSA) with iron oxide nanoparticles (IONPs) were investigated. The results showed that the presence of IONPs led to structural modifications and conformational changes in albumin, forming IONPs-BSA conjugates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Eduardo Fuentes-Lemus, Juan S. Reyes, Camilo Lopez-Alarcon, Michael J. Davies
Summary: This study explores the effect of crowding on protein glycation using high concentrations of proteins and alpha-oxoaldehyde metabolites. The results show that crowding modulates the extent of transferrin cross-links formation and the modification pathways in albumin and transferrin. Arginine is the most susceptible residue for modification, and crowding does not affect the extent of arginine and lysine loss, but the modification sites differ under dilute and crowded conditions.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Pyung Chun Oh, Woong Chol Kang, Bonghee Lee
Summary: Researchers investigated the utility of AGEs as prognostic biomarkers for AMI and found that CUPRAC-reactive AGEs exhibit various patterns of changes in serum samples of AMI patients.
Article
Biochemistry & Molecular Biology
Akhlas Tarannum, Zarina Arif, Mohd Mustafa, Faizan Abul Qais, Safia Habib, Moin Uddin, Khursheed Alam
Summary: This study explores the simultaneous effect of glycation and nitroxidation on the structure, conformation, and function of albumin. The glyco-nitro-oxidized albumin showed decreased free amino acid content and decreased affinity towards cobalt. The formation of carboxymethyl lysine and 3-nitrotyrosine in glyco-nitro-oxidized albumin was confirmed. This research provides a basis for studying the role of glyco-nitro-oxidized albumin in the pathogenesis and progression of autoimmune diseases, including rheumatoid arthritis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Medicine, Research & Experimental
Kamel Chettab, Eva-Laure Matera, Maxime Lafond, Durieux Coralie, Camille Favin-Leveque, Clemence Goy, Regina Strakhova, Jean-Louis Mestas, Cyril Lafon, Charles Dumontet
Summary: This study evaluated the delivery of bovine serum albumin (BSA) into human erythrocytes using a sonoporation device that generates and monitors acoustic stable cavitation. The results showed that stable cavitation allows efficient delivery of proteins into human erythrocytes with limited lysis.
MOLECULAR PHARMACEUTICS
(2022)
Article
Food Science & Technology
Sharat Sarmah, Archita Goswami, Vinay Kumar Belwal, Atanu Singha Roy
Summary: This study investigated the effects of two flavonoids, naringin and naringenin, on inhibiting glycation and AGEs formation of HSA, with naringenin showing stronger antiglycating potential than naringin due to better interactions with HSA.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Physical
Ajamaluddin Malik, Ghada Obeid Almutairi, Javed Masood Khan, Mona Alonazi, Sundus Mohammed AlRusaini, Abdullah S. Alhomida
Summary: Diabetes is a prevalent global disease that is expected to continue increasing. Non-enzymatic glycation, a key factor in diabetes, worsens disease complications and complicates health management. This study found that anionic surfactants interacting with proteins induce aggregation and amyloid formation, particularly in glycated proteins.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Biochemistry & Molecular Biology
Chloe Turpin, Aurelie Catan, Olivier Meilhac, Emmanuel Bourdon, Francois Canonne-Hergaux, Philippe Rondeau
Summary: This review highlights the role of erythrocytes as potent contributors to atherosclerotic plaque progression, going beyond their traditional role as passive gas carriers. The review describes the physiology of erythrocytes and pathology of ATH, as well as the links between erythrocytes and atherogenesis. It also discusses the potential pathological consequences of extravasated erythrocytes in plaque iron homeostasis, particularly in diabetic patients with hyperglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Sebastian Schmutzler, Michele Woelk, Ralf Hoffmann
Summary: D-glucose and D-fructose can react with amino groups, leading to proteins glycated at lysine residues. Metabolic diseases like diabetes elevate sugar levels, favoring glycation reactions and the formation of advanced glycation end products (AGEs) linked to diabetic complications and cardiovascular diseases. Current analytical methods for differentiating and quantifying Amadori- and Heyns-modified proteins in complex samples are limited.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sebastian Schmutzler, Michele Woelk, Ralf Hoffmann
Summary: D-glucose and D-fructose in mammals can react with amino groups, leading to glycated proteins. Metabolic diseases like diabetes elevate sugar levels, favoring glycation and the formation of advanced glycation end products (AGEs) linked to complications. Current analytical methods for differentiating and quantifying Amadori- and Heyns-modified proteins in complex samples are limited.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Moshtak Ahmed Jaseem Al Jaseem, K. M. Abdullah, Faizan Abul Qais, Anas Shamsi, Imrana Naseem
Summary: The study revealed that folic acid showed significant effects in inhibiting glycation and reducing the formation of AGEs. The binding between folic acid and HSA is primarily stabilized by hydrophobic interaction and hydrogen bonding in the complex. Various experimental results confirmed the antiglycation activity of folic acid.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Huijun Cui, Zhihuan Zang, Qiao Jiang, Yiwen Bao, Yunan Wu, Jiaxin Li, Yi Chen, Xiaoli Liu, Shufang Yang, Xu Si, Bin Li
Summary: The purpose of this study was to explore the optimal conditions for preparing BSA/CA-DEX conjugates using ultrasonic pretreatment combined with glycation. Ultrasonic pretreatment increased the grafting degree of BSA and CA, and also altered the secondary structure of the proteins. The U-G treated proteins showed improved solubility, thermal stability, foaming, and emulsifying capacity, with a greater impact on BSA. Furthermore, the U-G-BSA/CA-CMC complexes exhibited protection of ACNs, delaying their thermal degradation. Overall, protein conjugates treated with ultrasonic pretreatment and glycation have excellent functionality and potential as carrier materials.
Article
Geriatrics & Gerontology
Charlotte Brun, Oscar Hernandez-Alba, Agnes Hovasse, Francois Criscuolo, Christine Schaeffer-Reiss, Fabrice Bertile
Summary: A study found that birds have high plasma glucose levels but do not exhibit protein glycation. This may be due to their unique structural features. However, high levels of glycated proteins were measured in the plasma of zebra finches. The correlations between glucose, age, and body mass with glycated proteins and hemoglobin isoforms suggest that these variables could be useful molecular tools to monitor glycation and its link with individual fitness.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rashmi S. Tupe, Nilima Bangar, Akib Nisar, Amruta Kulkarni, Neena Sankhe, Rohan Chauhan, Nidhi Mistry, Shamim Shaikh
Summary: Piperine demonstrates preventive, protective, and therapeutic effects on albumin glycation, while also safeguarding red blood cells from oxidative damage induced by glycated albumin.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicolas Martinez-Majander, Daniel Gordin, Lotta Joutsi-Korhonen, Titta Salopuro, Krishna Adeshara, Gerli Sibolt, Sami Curtze, Jani Pirinen, Ron Liebkind, Lauri Soinne, Tiina Sairanen, Juha Sinisalo, Mika Lehto, Per-Henrik Groop, Turgut Tatlisumak, Jukka Putaala
Summary: The study found that endothelial dysfunction is independently associated with early-onset CIS in men and patients approaching middle age. However, there was no association between endothelial function and CIS in the entire study cohort.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Krishna A. Adeshara, Nilima Bangar, Arundhati G. Diwan, Rashmi S. Tupe
Summary: This study aims to explore the relationship between the interaction of advanced glycation end products (AGEs) and receptor for advanced glycation end products (RAGE) with oxidative stress and inflammation in vascular complications of diabetes. The results showed that patients with diabetes had higher levels of glycation adducts, oxidative stress, and inflammation, especially in patients with nephropathy. This study provides the first evidence of the existence of four different RAGE isoforms in diabetes and complications.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Akib Nisar, Devangi K. Ajabia, Sanskruthi B. Agrawal, Sanjana Varma, Bhushan P. Chaudhari, Rashmi S. Tupe
Summary: The interaction and structural modifications of bovine serum albumin (BSA) with iron oxide nanoparticles (IONPs) were investigated. The results showed that the presence of IONPs led to structural modifications and conformational changes in albumin, forming IONPs-BSA conjugates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Deepesh D. Gaikwad, Nilima S. Bangar, Mayura M. Apte, Armaan Gvalani, Rashmi S. Tupe
Summary: This study discovers that the interaction between aldosterone and glycated albumin in diabetic nephropathy can cause oxidative stress, reduce levels of antioxidants and glycation detoxifying enzymes, and result in renal cell damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Ankita Durge, Isha Sharma, Rashmi Santosh Tupe
Summary: The glycation of biomolecules is a major factor in diabetic nephropathy and end-stage kidney disease. Advances in noncoding RNA research, particularly the long noncoding RNAs (lncRNAs), have provided new insights into potential therapies for glycation-related conditions. However, there are still methodological constraints in the study of lncRNAs. This review discusses the role of lncRNAs in glycation and the possible use of lncRNA-based therapeutics.
Article
Biochemistry & Molecular Biology
Sera A. Fernandes, Subrata Dasgupta, Rashmi S. Tupe, Ejaj K. Pathan
Summary: Glycation is a reaction that leads to protein inactivation, but the enzyme hDJ-1 can reverse this process. The specificity of hDJ-1 is regulated by its active site residue Cys106, and structural analysis suggests a potential role of Glu18. Modifying Glu18 to Asp18 improves the substrate specificity of hDJ-1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Nilima S. Bangar, Selvan Ravindran, Shamim A. Shaikh, Nilesh Shah, Rashmi S. Tupe
Summary: This study evaluated the phytochemicals and antioxidant potential of Syzyg formulations, as well as their effects on glycation of human serum albumin. The results showed that Syzyg formulations inhibited glycation and maintained the structural and functional integrity of HSA.
Article
Food Science & Technology
Harsha V. Sail, Ashwini D. Jagdale, Muskan R. Thakur, Rashmi S. Tupe
Summary: This study assessed the effects of the Maillard reaction on the glycation, structural, and functional characteristics of Maillard reaction products (MRPs) of casein acid hydrolysate (CAH). The results showed that MRPs exhibited improved thermal stability, antioxidant potential, and emulsifying properties.
INTERNATIONAL DAIRY JOURNAL
(2024)
Review
Chemistry, Medicinal
Rahul Shivaji Patil, Rashmi Santosh Tupe
Summary: Diabetes and neurodegenerative diseases are increasing globally, and protein glycation and gut microbes are believed to play important roles in these conditions. Protein glycation can affect protein structure and toxicity, while gut microbes and their metabolites are associated with human health and diseases. Understanding the link between glycation, gut microbes, and these diseases is essential for developing therapeutic strategies.
MEDICINAL RESEARCH REVIEWS
(2023)
Editorial Material
Endocrinology & Metabolism
Jun Wada, Rashmi S. Tupe, Isha Sharma
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mayura Apte, Mohd Shahnawaz Khan, Nilima Bangar, Armaan Gvalani, Huma Naz, Rashmi S. Tupe
Summary: This study found that Aldo has a significant impact on glycation, and the AGEs-Aldo complex induces inflammatory responses through RAGE-MR interaction in DN.
Article
Chemistry, Applied
Chaitra R. Bandiwadekar, Ashwini D. Jagdale, Ankita S. Durge, Tejaswini A. Pachpor, Rashmi S. Tupe
Summary: The modification of chitosan through the Maillard reaction with different saccharides can enhance its functional and biological properties. The CMRPs formed under different reaction conditions showed improved emulsifying activity, antioxidant potential, and gel formation, indicating their potential application in food preservation and packaging.
FOOD HYDROCOLLOIDS
(2023)
Review
Biochemistry & Molecular Biology
Nilima S. Bangar, Armaan Gvalani, Saheem Ahmad, Mohd S. Khan, Rashmi S. Tupe
Summary: Glycation refers to the reaction between reducing sugars and free amino groups in proteins, resulting in the formation of various products. Glycation plays a significant role in metabolic diseases, brain disorders, aging, and gut microbiome dysregulation. It affects the development of diseases by altering protein structure and function.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
