Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

The taste of heavy metals: Gene regulation by MTF-1

(2012) Viola Günther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

When less is more: the forbidden fruits of gene repression in the adult β-cell

(2012) T. J. Pullen et al.   DIABETES OBESITY & METABOLISM

Regulation and functional effects of ZNT8 in human pancreatic islets

(2012) Bruno Lefebvre et al.   JOURNAL OF ENDOCRINOLOGY

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background

(2012) Lynley D. Pound et al.   PLoS One

Zinc Transporter 8 (ZnT8) Expression Is Reduced by Ischemic Insults: A Potential Therapeutic Target to Prevent Ischemic Retinopathy

(2012) Michael DeNiro et al.   PLoS One

A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells

(2011) R. Olsson et al.   DIABETES

Increased Numbers of Low-Oxygenated Pancreatic Islets After Intraportal Islet Transplantation

(2011) R. Olsson et al.   DIABETES

Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates MouseIns2but NotIns1Gene Expression in Pancreatic Beta Cells (MIN6)

(2011) Gargi Meur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Regulates Free Cytosolic Zn2+Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells

(2011) Elisa A. Bellomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Hypoxia of Pancreatic β-Cells Due to High Levels of Oxygen Consumption for Insulin Secretionin Vitro

(2011) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexins protect mouse pancreatic β cells against apoptosis

(2011) Philippe Klee et al.   JOURNAL OF CLINICAL INVESTIGATION

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)

(2011) D. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulatesSlc30a8gene transcription through an intronic enhancer

(2010) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Rat islet cell aggregates are superior to islets for transplantation in microcapsules

(2010) E. S. O’Sullivan et al.   DIABETOLOGIA

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function

(2010) Malek El Muayed et al.   JOURNAL OF ENDOCRINOLOGY

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

(2010) Lavinia Nardinocchi et al.   PLoS One

Think zinc: New roles for zinc in the control of insulin secretion

(2010) Guy A. Rutter   Islets

Oxygenation of islets and its role in transplantation

(2009) Joey Lau et al.   Current Opinion in Organ Transplantation

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

(2009) Jan L Vinkenborg et al.   NATURE METHODS

SLC30A3 Responds to Glucose- and Zinc Variations in ß-Cells and Is Critical for Insulin Production and In Vivo Glucose-Metabolism During ß-Cell Stress

(2009) Kamille Smidt et al.   PLoS One

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?

(2009) Lærke Egefjord et al.   BMC Endocrine Disorders

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

(2008) K. Kirchhoff et al.   DIABETOLOGIA

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study

(2008) T. W. Boesgaard et al.   DIABETOLOGIA

Collagenase Penetrates Human Pancreatic Islets Following Standard Intraductal Administration

(2008) Sarah E. Cross et al.   TRANSPLANTATION