Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells

Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens

(2017) Fadi J Najm et al.   NATURE BIOTECHNOLOGY

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions

(2017) John Paul Shen et al.   NATURE METHODS

Human gene essentiality

(2017) István Bartha et al.   NATURE REVIEWS GENETICS

Am I ready for CRISPR? A user's guide to genetic screens

(2017) John G. Doench   NATURE REVIEWS GENETICS

PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens

(2017) Walter F Lenoir et al.   NUCLEIC ACIDS RESEARCH

Improved detection of synthetic lethal interactions inDrosophilacells using variable dose analysis (VDA)

(2017) Benjamin E. Housden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted genetics inDrosophilacell lines: Inserting single transgenes in vitro

(2016) Sathiya N. Manivannan et al.   FLY

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

(2016) Bastiaan Evers et al.   NATURE BIOTECHNOLOGY

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes

(2016) David W Morgens et al.   NATURE BIOTECHNOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

A chemical-inducible CRISPR–Cas9 system for rapid control of genome editing

(2016) Kaiwen Ivy Liu et al.   Nature Chemical Biology

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

Tools for Targeted Genome Engineering of Established Drosophila Cell Lines

(2015) L. Cherbas et al.   GENETICS

A Genome-Wide CRISPR Library for High-Throughput Genetic Screening in Drosophila Cells

(2015) Andrew R. Bassett et al.   Journal of Genetics and Genomics

Small molecule–triggered Cas9 protein with improved genome-editing specificity

(2015) Kevin M Davis et al.   Nature Chemical Biology

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

(2015) Benjamin E. Housden et al.   Science Signaling

Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

(2015) Benjamin E. Housden et al.   Science Signaling

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Microhomology-based choice of Cas9 nuclease target sites

(2014) Sangsu Bae et al.   NATURE METHODS

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps

(2014) Martin Kampmann et al.   Nature Protocols

RNAi screening comes of age: improved techniques and complementary approaches

(2014) Stephanie E. Mohr et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA copy number evolution in Drosophila cell lines

(2014) Hangnoh Lee et al.   GENOME BIOLOGY

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9

(2013) X. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Protein Complex-Based Analysis Framework for High-Throughput Data Sets

(2013) A. Vinayagam et al.   Science Signaling

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

Stringent Analysis of Gene Function and Protein-Protein Interactions Using Fluorescently Tagged Genes

(2011) R. A. Neumuller et al.   GENETICS

On the Origins of Mendelian Disease Genes in Man: The Impact of Gene Duplication

(2011) J. E. Dickerson et al.   MOLECULAR BIOLOGY AND EVOLUTION

Generation of stable Drosophila cell lines using multicistronic vectors

(2011) Monika González et al.   Scientific Reports

Terminin: A protein complex that mediates epigenetic maintenance ofDrosophilatelomeres

(2011) Grazia D. Raffa et al.   Nucleus

Inducible somatic oocyte destruction in response to rapamycin requires wild-type regulation of follicle cell epithelial polarity

(2010) T C Thomson et al.   CELL DEATH AND DIFFERENTIATION

Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex

(2010) G. D. Raffa et al.   GENES & DEVELOPMENT

A whole genome RNAi screen ofDrosophilaS2 cell spreading performed using automated computational image analysis

(2010) Michael V. D'Ambrosio et al.   JOURNAL OF CELL BIOLOGY

Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter

(2010) Jane Yuxia Qin et al.   PLoS One

TagDust--a program to eliminate artifacts from next generation sequencing data

(2009) T. Lassmann et al.   BIOINFORMATICS

Intrakinetochore localization and essential functional domains of Drosophila Spc105

(2009) Ralf B Schittenhelm et al.   EMBO JOURNAL

Unlocking the secrets of the genome

(2009) Susan E. Celniker et al.   NATURE

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes

(2008) Michele Markstein et al.   NATURE GENETICS