A Closer Look at Aryne Chemistry: Details that Remain Mysterious

Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolines via amide activation

(2012) Mi-Na Zhao et al.   CHEMICAL COMMUNICATIONS

A Comprehensive History of Arynes in Natural Product Total Synthesis

(2012) Pamela M. Tadross et al.   CHEMICAL REVIEWS

Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes

(2012) Anup Bhunia et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of o-(Dimethylamino)aryl Ketones, Acridones, Acridinium Salts, and 1H-Indazoles by the Reaction of Hydrazones and Arynes

(2012) Anton V. Dubrovskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Formation of Acridones by Ethylene Extrusion in the Reaction of Arynes with β-Lactams and Dihydroquinolinones

(2012) Yuesi Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Substituted 1H-Indazoles from Arynes and Hydrazones

(2012) Pan Li et al.   JOURNAL OF ORGANIC CHEMISTRY

The hexadehydro-Diels–Alder reaction

(2012) Thomas R. Hoye et al.   NATURE

Silver triflate-catalyzed tandem reaction of N′-(2-alkynylbenzylidene)hydrazide with pyridyne

(2012) Lingyong Jiang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

One-pot synthesis of 1-alkyl-1H-indazoles from 1,1-dialkylhydrazones via aryne annulation

(2012) Nataliya A. Markina et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aryne cycloaddition with 3-oxidopyridinium species

(2012) Hailong Ren et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselective synthesis of 2-(2-hydroxyaryl)pyridines from the reactions of benzynes with pyridine N-oxides

(2012) Balagopal S. Shaibu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Use of benzynes for the synthesis of heterocycles

(2012) Anton V. Dubrovskiy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Transition-Metal-Free α-Arylation of β-Keto Amides via an Interrupted Insertion Reaction of Arynes

(2012) Kishor Mohanan et al.   ORGANIC LETTERS

Cycloaddition Reaction of 2-Vinylazetidines with Benzyne: A Facile Access to 1-Benzazocine Derivatives

(2012) Takashi Aoki et al.   ORGANIC LETTERS

Transition-Metal-Free C-Arylation at Room Temperature by Arynes

(2012) Ranjeet A. Dhokale et al.   ORGANIC LETTERS

Aryne Insertion into I–I σ-Bonds

(2012) Diego Rodríguez-Lojo et al.   ORGANIC LETTERS

Aryne Insertion Reactions into Carbon-Carbon σ-Bonds

(2012) Hiroto Yoshida et al.   SYNLETT

Synthesis of Aryl-Substituted 1,4-Dihydroquinolines by [4+2] Cycloaddition of Benzyne with 1-Azadienes

(2012) Keith Mead et al.   SYNLETT

Nucleophilic addition to 2,3-pyridyne and synthesis of benzonaphthyridinones

(2012) Yuesi Fang et al.   TETRAHEDRON

Synthesis of 9-substituted xanthenes by the condensation of arynes with ortho-hydroxychalcones

(2012) Chun Lu et al.   TETRAHEDRON LETTERS

A C–N insertion of β-lactam to benzyne: unusual formation of acridone

(2012) Jimin Kim et al.   TETRAHEDRON LETTERS

Three-Component Coupling of Arynes and Organic Bromides

(2011) Hiroto Yoshida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition-Metal-Free Direct Arylation of Anilines

(2011) Tracey Pirali et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction of arynes with amino acid esters

(2011) Kentaro Okuma et al.   CHEMICAL COMMUNICATIONS

Synthesis ofN-Arylisatins by the Reaction of Arynes with Methyl 2-Oxo-2-(arylamino)acetates

(2011) Donald C. Rogness et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2H-Indazoles by the [3 + 2] Dipolar Cycloaddition of Sydnones with Arynes

(2011) Yuesi Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Aryne [3 + 2] cycloaddition with N-sulfonylpyridinium imides and in situ generated N-sulfonylisoquinolinium imides: a potential route to pyrido[1,2-b]indazoles and indazolo[3,2-a]isoquinolines

(2011) Jingjing Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Silver Triflate Catalyzed Reaction of 2-Alkynylbenzaldoxime with Aryne

(2011) Hui Ren et al.   ORGANIC LETTERS

Synthesis ofo-(Dimethylamino)aryl Ketones and Acridones by the Reaction of 1,1-Dialkylhydrazones and Arynes

(2011) Anton V. Dubrovskiy et al.   ORGANIC LETTERS

Efficient Assembly of Chromone Skeleton from 2,3-Allenoic Acids and Benzynes

(2011) Guobi Chai et al.   ORGANIC LETTERS

The Benzyne Fischer-Indole Reaction

(2011) Donald McAusland et al.   ORGANIC LETTERS

Synthesis of 3-Substituted Indazoles from Arynes andN-Tosylhydrazones

(2011) Pan Li et al.   ORGANIC LETTERS

Insertion of arynes into the carbon–oxygen double bond of amides and its application into the sequential reactions

(2011) Eito Yoshioka et al.   TETRAHEDRON

A facile N-arylation of acetanilides with arynes

(2011) James C. Haber et al.   TETRAHEDRON LETTERS

Synthesis of Dihydrobenzisoxazoles by the [3 + 2] Cycloaddition of Arynes and Oxaziridines

(2010) Arif Kivrak et al.   JOURNAL OF ORGANIC CHEMISTRY

Intermolecular C−O Addition of Carboxylic Acids to Arynes

(2010) Anton V. Dubrovskiy et al.   ORGANIC LETTERS

The Benzyne Aza-Claisen Reaction

(2009) Alastair A. Cant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cascade Nucleophilic Addition−Cyclic Michael Addition of Arynes and Phenols/Anilines Bearing Ortho α,β-Unsaturated Groups: Facile Synthesis of 9-Functionalized Xanthenes/Acridines

(2009) Xian Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enamide-Benzyne-[2 + 2] Cycloaddition: Stereoselective Tandem [2 + 2]−Pericyclic Ring-Opening−IntramolecularN-Tethered [4 + 2] Cycloadditions

(2009) John B. Feltenberger et al.   ORGANIC LETTERS

Insertion of Benzene Rings into the Amide Bond: One-Step Synthesis of Acridines and Acridones from Aryl Amides

(2009) Didier G. Pintori et al.   ORGANIC LETTERS

Rapid synthesis of the indole-indolone scaffold via [3+2] annulation of arynes by methyl indole-2-carboxylates

(2009) Donald C. Rogness et al.   TETRAHEDRON LETTERS

Orthogonal Synthesis of Indolines and Isoquinolines via Aryne Annulation

(2008) Christopher D. Gilmore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction of Benzyne with Salicylaldehydes: General Synthesis of Xanthenes, Xanthones, and Xanthols

(2008) Kentaro Okuma et al.   ORGANIC LETTERS

Synthesis of Indazoles by the [3+2] Cycloaddition of Diazo Compounds with Arynes and Subsequent Acyl Migration

(2007) Zhijian Liu et al.   JOURNAL OF ORGANIC CHEMISTRY