Article
Cell & Tissue Engineering
Camila Medrano-Trochez, Paramita Chatterjee, Pallab Pradhan, Hazel Y. Stevens, Molly E. Ogle, Edward A. Botchwey, Joanne Kurtzberg, Carolyn Yeago, Greg Gibson, Krishnendu Roy
Summary: This study showed that donor differences in hMSC transcriptome are minor compared to the intrinsic differences in tissue-of-origin. hMSCs with different transcriptomic profiles exhibited potential differences in functional characteristics, contributing to the understanding of differences in out-of-thaw therapeutic hMSC products.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Jin Zhang, Zhenghui Li, Akila Chandrasekar, Shun Li, Albert Ludolph, Tobias Maria Boeckers, Markus Huber-Lang, Francesco Roselli, Florian Olde Heuvel
Summary: The consequences of systemic inflammation after traumatic brain injury (TBI) are a significant burden on almost all organs, with inflammation and immunosuppression occurring concurrently. The spleen, as one of the main immune regulatory organs, interacts extensively with the brain. Nerve fibers and brain-derived circulating mediators have been observed to directly interact with immune cells in the spleen along the brain-spleen axis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell & Tissue Engineering
Zahra Azizi, Roya Abbaszadeh, Roxana Sahednasagh, Amir Norouzy, Elahe Motevaseli, Kathrin Maedler
Summary: Bone marrow mesenchymal stromal cells have anti-inflammatory and pro-survival properties, and their fusion with transplanted islets can improve diabetes treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Mario Barilani, Christopher Lovejoy, Roberta Piras, Andrey Y. Abramov, Lorenza Lazzari, Plamena R. Angelova
Summary: The study found that aging in MSCs is associated with changes in mitochondrial metabolism, including a decrease in mitochondrial membrane potential, lower NADH levels, and higher mitochondrial DNA content. Despite higher ATP levels in aged cells, increased rates of mitophagy lead to decreased overall mitochondrial mass. Additionally, changes in mitochondrial metabolism in aged MSCs result in the overproduction of reactive oxygen species in mitochondria, which is compensated by higher levels of the endogenous antioxidant glutathione.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Polina E. Panchenko, Lea Hippauf, Jan Pieter Konsman, Jerome Badaut
Summary: Astrocytes play a crucial role in maintaining brain homeostasis and respond to brain injury by undergoing morphological, proteomic, and transcriptomic changes. Traumatic brain injury (TBI) in children can lead to long-term health complications, yet the underlying pathophysiology is not fully understood. This review focuses on the immune role of astrocytes in pediatric TBI, exploring their contribution to local inflammatory cascades and recruitment of immune cells. Understanding the early changes in astrocytic phenotype and their impact on brain development can provide insights into neurological outcomes and potential therapeutic strategies.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Chunhao Zhang, Shiwen Chen
Summary: Traumatic brain injury (TBI) is the primary cause of morbidity and disability worldwide, leading to brain edema, axonal damage, and hypoxia. TBI affects the blood-brain barrier function, promotes inflammatory responses, and increases oxidative stress. Long-term effects of TBI have gained increasing attention in recent years. TREM2, expressed in microglia, has been associated with neurodegenerative disorders. This review highlights the potential neuroprotective role of TREM2 in neurodegenerative disorders following TBI by modulating microglial cell function.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Julianna Lilienberg, Agota Apati, Janos M. Rethelyi, Laszlo Homolya
Summary: The study reveals that microglial cells have different effects on the proliferation and neurite outgrowth of neural progenitor cells and hippocampal neurons. Proinflammatory stimulated microglia promote both proliferation and neurite generation, while anti-inflammatory stimulated microglia enhance neurite outgrowth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
A. P. Lykov, M. A. Surovtseva, N. A. Bondarenko, I. I. Kim, Ya Sh Schwartz, O. Poveshchenko
Summary: Preconditioning of human bone marrow mononuclear cells with erythropoietin affects the immunophenotype of immunocompetent cells and paracrine activity of mouse splenocytes. Changes in the expression of erythropoietin receptors were observed, leading to alterations in the numbers of different types of immune cells. The conditioned medium or erythropoietin treatment from the bone marrow cells also affected cell apoptosis/necrosis and intracellular enzyme activity in splenocytes.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Cell Biology
Diego Garcia-Ayuso, Johnny Di Pierdomenico, David Garcia-Bernal, Manuel Vidal-Sanz, Maria P. Villegas-Perez
Summary: Retinal degenerative diseases causing photoreceptor loss are a leading cause of irreversible vision loss. Currently, there are limited treatments available. Transplantation of bone marrow derived-mononuclear stem cells has shown promise in protecting photoreceptors and may have a wide range of clinical applications. Future research may combine this therapy with other treatments to achieve better therapeutic effects.
NEURAL REGENERATION RESEARCH
(2022)
Article
Critical Care Medicine
G. Bellingan, F. Jacono, J. Bannard-Smith, D. Brealey, N. Meyer, D. Thickett, D. Young, A. Bentley, B. J. McVerry, R. G. Wunderink, K. C. Doerschug, C. Summers, M. Rojas, A. Ting, E. D. Jenkins
Summary: Bone marrow-derived, allogeneic, multipotent adult progenitor cells showed safety and tolerability in patients with ARDS, improving clinical outcomes and quality of life. Larger trials are needed to evaluate the therapeutic efficacy and optimal patient population based on the promising results from this trial.
INTENSIVE CARE MEDICINE
(2022)
Article
Neurosciences
Jin Wang, Yushu Hou, Lixia Zhang, Min Liu, Jianshuai Zhao, Zhen Zhang, Yulong Ma, Wugang Hou
Summary: The study demonstrated that E2 treatment significantly alleviated TBI-induced neuroinflammatory injury by inhibiting microglia and astrocyte activation, reducing neurotoxic astrocyte activation, and inhibiting the TLR4/NF-kappa B pathway. E2 treatment may be a potential therapy strategy for TBI-induced neuroinflammation injury.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Miguel A. Cuadros, M. Rosario Sepulveda, David Martin-Oliva, Jose L. Marin-Teva, Veronika E. Neubrand
Summary: Microglia are tissue-resident macrophages in the central nervous parenchyma, originating from yolk sac precursors. In addition to true microglia, there are also microglia-like cells from bone marrow that mainly appear under pathological conditions. These two types of cells share similarities but have differences, which are important for understanding their development and potential therapeutic strategies for diseases they are involved in.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Orthopedics
Ava Brozovich, Brent J. Sinicrope, Guillermo Bauza, Federica Banche Niclot, David Lintner, Francesca Taraballi, Patrick C. McCulloch
Summary: This study aimed to characterize bone marrow aspirate (BMA) versus bone marrow aspirate concentrate (BMAC) for mesenchymal stem cell (MSC) quantity, potency, and cytokine profile. The results showed significantly higher MSC concentration and CFU number in BMA compared to BMAC, with BMAC failing to concentrate MSC in 6 out of 8 samples.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Review
Cell Biology
Cyril Bouland, Pierre Philippart, Didier Dequanter, Florent Corrillon, Isabelle Loeb, Dominique Bron, Laurence Lagneaux, Nathalie Meuleman
Summary: Bone regeneration is a complex process relying on interactions between osteogenesis and angiogenesis. Tissue engineering provides strategies with regenerative cell sources, growth factors, and mechanical stimulation. Vascularization is crucial for bone formation and function, with studies showing synergy between mesenchymal stromal cells (MSCs) and endothelial progenitor cells (EPCs) in promoting regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Andreas Bruzelius, Isabel Hidalgo, Antonio Boza-Serrano, Anna-Giorgia Hjelmer, Amelie Tison, Tomas Deierborg, Johan Bengzon, Tania Ramos-Moreno
Summary: A study identified a stromal microglial progenitor (STR-MP) in human bone marrow that can generate microglia-like cells in vitro, potentially for use in cell-based therapies and disease modeling. These stromal microglia (STR-M) cells exhibit phagocytic ability, classical activation, and survival in human brain tissue. This finding suggests that bone marrow harbors a source of microglia-like precursors that can be utilized in patient-centered rapid derivative approaches.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Siqin Zhaorigetu, Henry Bair, Jonathan Lu, Di Jin, Scott D. Olson, Matthew T. Harting
JOURNAL OF VASCULAR RESEARCH
(2018)
Article
Cell & Tissue Engineering
Matthew T. Harting, Amit K. Srivastava, Siqin Zhaorigetu, Henry Bair, Karthik S. Prabhakara, Naama E. Toledano Furman, Jody V. Vykoukal, Katherine A. Ruppert, Charles S. Cox, Scott D. Olson
Article
Immunology
Supinder S. Bedi, Benjamin M. Aertker, George P. Liao, Henry W. Caplan, Deepa Bhattarai, Fanni Mandy, Franciska Mandy, Luis G. Fernandez, Pamela Zelnick, Matthew B. Mitchell, Walter Schiffer, Margaret Johnson, Emma Denson, Karthik Prabhakara, Hasen Xue, Philippa Smith, Karen Uray, Scott D. Olson, Robert W. Mays, Charles S. Cox
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Biotechnology & Applied Microbiology
Karthik S. Prabhakara, Daniel J. Kota, Gregory H. Jones, Amit K. Srivastava, Charles S. Cox, Scott D. Olson
Article
Multidisciplinary Sciences
Katherine A. Ruppert, Tin T. Nguyen, Karthik S. Prabhakara, Naama E. Toledano Furman, Amit K. Srivastava, Matthew T. Harting, Charles S. Cox, Scott D. Olson
SCIENTIFIC REPORTS
(2018)
Article
Cell & Tissue Engineering
Amit K. Srivastava, Karthik S. Prabhakara, Daniel Jkota, Supinder S. Bedi, Fabio Triolo, Katherine S. Brown, Matthew L. Skiles, Heather L. Brown, Charles S. Cox, Scott D. Olson
REGENERATIVE MEDICINE
(2019)
Review
Immunology
Henry Caplan, Scott D. Olson, Akshita Kumar, Mitchell George, Karthik S. Prabhakara, Pamela Wenzel, Supinder Bedi, Naama E. Toledano-Furman, Fabio Triolo, Julian Kamhieh-Milz, Guido Moll, Charles S. Cox
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Neurosciences
Nikunj Satani, Kaavya Giridhar, Chunyan Cai, Natalia Wewior, Dominique D. Norris, Scott D. Olson, Jaroslaw Aronowski, Sean I. Savitz
Article
Cell & Tissue Engineering
Suchit Sahai, Marysuna Wilkerson, Hasen Xue, Nicolas Moreno, Louis Carrillo, Rene Flores, Matthew R. Greives, Scott D. Olson, Charles S. Cox, Fabio Triolo
TISSUE ENGINEERING PART A
(2020)
Article
Cell & Tissue Engineering
Mitchell J. George, Karthik Prabhakara, Naama E. Toledano-Furman, Brijesh S. Gill, Charles E. Wade, Bryan A. Cotton, Andrew P. Cap, Scott D. Olson, Charles S. Cox
STEM CELLS TRANSLATIONAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Katherine A. Ruppert, Karthik S. Prabhakara, Naama E. Toledano-Furman, Sanjna Udtha, Austin Q. Arceneaux, Hyeonggeun Park, An Dao, Charles S. Cox, Scott D. Olson
Article
Pediatrics
Madeline N. Monroe, Siqin Zhaorigetu, Vikas S. Gupta, Di Jin, Katelyn D. Givan, Alexander L. Curylo, Scott D. Olson, Charles S. Cox, Ana Segura, Louis Maximilian Buja, Kathryn Jane Grande-Allen, Matthew T. Harting
PEDIATRIC PULMONOLOGY
(2020)
Article
Multidisciplinary Sciences
Margaret L. Jackson, Katherine A. Ruppert, Daniel J. Kota, Karthik S. Prabhakara, Robert A. Hetz, Benjamin M. Aertker, Supinder Bedi, Robert W. Mays, Scott D. Olson, Charles S. Cox
Article
Biotechnology & Applied Microbiology
Yungang Xu, Weiling Zhao, Scott D. Olson, Karthik S. Prabhakara, Xiaobo Zhou
Article
Biochemical Research Methods
Naama E. Toledano Furman, Karthik S. Prabhakara, Supinder Bedi, Charles S. Cox, Scott D. Olson