Signaling control of the constitutive androstane receptor (CAR)

Chemoprevention of Head and Neck Cancer by Simultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies

(2013) D. M. Shin et al.   CLINICAL CANCER RESEARCH

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

(2013) S. Mutoh et al.   Science Signaling

The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies

(2012) D. Wang et al.   BLOOD

Constitutive androstane receptor activation by 2,4,6-triphenyldioxane-1,3 suppresses the expression of the gluconeogenic genes

(2012) Ekaterina M. Kachaylo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells

(2011) S Chakraborty et al.   BRITISH JOURNAL OF CANCER

Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

(2011) Makoto Osabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with a constitutive androstane receptor ligand ameliorates the signs of preeclampsia in high-fat diet-induced obese pregnant mice

(2011) H. Masuyama et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines

(2011) Hiroki Kamino et al.   Cancer Genetics

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis

(2010) Daichi Takizawa et al.   CARCINOGENESIS

Peroxisome Proliferator-activated Receptor Alpha (PPARα) Agonists Induce Constitutive Androstane Receptor (CAR) and Cytochrome P450 2B in Rat Primary Hepatocytes

(2010) Kosuke Saito et al.   Drug Metabolism and Pharmacokinetics

Activation of xenobiotic receptors: driving into the nucleus

(2010) Haishan Li et al.   Expert Opinion on Drug Metabolism & Toxicology

5-Aminoimidazole-4-carboxamide-1-β-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner

(2010) Yuichiro Kanno et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Genetic Polymorphism and Toxicology—With Emphasis on Cytochrome P450

(2010) Inger Johansson et al.   TOXICOLOGICAL SCIENCES

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

(2010) Jillian Ross et al.   TOXICOLOGICAL SCIENCES

Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region

(2009) Kouichi Yoshinari et al.   BIOCHEMICAL PHARMACOLOGY

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor  , and Nuclear Factor Erythroid 2-Related Factor 2

(2009) D. B. Buckley et al.   DRUG METABOLISM AND DISPOSITION

Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes

(2009) H. Li et al.   DRUG METABOLISM AND DISPOSITION

Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress

(2009) Makoto Osabe et al.   FEBS LETTERS

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

(2009) Shingo Mutoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Octachlorostyrene Induces Cytochrome P450, UDP-glucuronosyltransferase, and Sulfotransferase via the Aryl Hydrocarbon Receptor and Constitutive Androstane Receptor

(2009) Yukie Yanagiba et al.   TOXICOLOGICAL SCIENCES

CYP2B6: New Insights into a Historically Overlooked Cytochrome P450 Isozyme

(2008) Hongbing Wang et al.   CURRENT DRUG METABOLISM

The Peripheral Benzodiazepine Receptor Ligand 1-(2-Chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide Is a Novel Antagonist of Human Constitutive Androstane Receptor

(2008) L. Li et al.   MOLECULAR PHARMACOLOGY

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

(2008) A. Roth et al.   MOLECULAR PHARMACOLOGY

PPP1R16A, The Membrane Subunit of Protein Phosphatase 1 , Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor

(2008) T. Sueyoshi et al.   MOLECULAR PHARMACOLOGY

SIK2 Can be Activated by Deprivation of Nutrition and It Inhibits Expression of Lipogenic Genes in Adipocytes

(2008) Jing Du et al.   Obesity