期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 348, 期 1, 页码 120-127出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.07.047
关键词
Adipocytokine; Constitutive androstane receptor; Insulin resistance; Preeclampsia
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [17591739, 22591856]
- Okayama Medical Foundation
- Grants-in-Aid for Scientific Research [23390390, 17591739, 22591856] Funding Source: KAKEN
Constitutive androstane receptor (CAR) has been reported to decrease insulin resistance, while obesity and insulin resistance may also be involved in the pathogenesis of preeclampsia. We examined whether a CAR ligand, 1,4-bis(2-(3,5-dichloropyridyloxy)) benzene (TCPOBOP), can ameliorate the signs of preeclampsia in high-fat diet (HFD)-induced obese pregnant mice to examine a possibility of CAR as a therapeutic target. We employed six groups including non-pregnant, NED-fed or control diet-fed pregnant mice with or without TCPOBOP treatment (n = 6). In HFD pregnant mice, insulin resistance increased with increasing expression of gluconeogenic and lipogenic genes and abnormal adipocytokine levels. TCPOBOP treatment, which was once-weekly intraperitoneal injections (0.5 mg/kg) and started at day 0.5 of pregnancy, improved glucose tolerance with significant changes of gluconeogenic, lipogenic and adipocytokine genes. HFD pregnant mice had hypertension and proteinuria, while TCPOBOP treatment ameliorated these signs. Our data suggested CAR might be a potential therapeutic target for obese preeclampsia patients with insulin resistance. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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