Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine in murine models

Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors

(2015) Encouse B. Golden et al.   Neurosurgical Focus

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

(2015) Hye Suk Lee et al.   Drug Design Development and Therapy

A method to measure cardiac autophagic flux in vivo

(2014) Eri Iwai-Kanai et al.   Autophagy

Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation

(2014) Bo Liu et al.   Autophagy

Influenza virus H1N1 activates platelets through Fc RIIA signaling and thrombin generation

(2014) E. Boilard et al.   BLOOD

Evidence of impairment of normal inflammatory reaction by a high-fat diet

(2014) C Laflamme et al.   GENES AND IMMUNITY

Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia

(2014) SHAN SHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Time‐Dependent Effects of Hydrophobic Amine‐Containing Drugs on Lysosome Structure and Biogenesis in Cultured Human Fibroblasts

(2014) Randall Logan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Cell Line NCl-H441 Is a Useful in Vitro Model for Transport Studies of Human Distal Lung Epithelial Barrier

(2014) Johanna J. Salomon et al.   MOLECULAR PHARMACEUTICS

Cell metabolism: Autophagy transcribed

(2014) Carmine Settembre et al.   NATURE

High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: Comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs

(2013) Caroline Roy et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response

(2012) Jason Baik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells

(2012) Takeshi Funakoshi et al.   BRAIN RESEARCH

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

pH-Sensitive Capsules as Intracellular Optical Reporters for Monitoring Lysosomal pH Changes Upon Stimulation

(2012) Pilar RiveraGil et al.   Small

Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo

(2011) Joon-Ho Sheen et al.   CANCER CELL

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

(2011) Reza Ehsanian et al.   Cell Communication and Signaling

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Cation trapping by cellular acidic compartments: Beyond the concept of lysosomotropic drugs

(2011) François Marceau et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

(2011) Patrick M Chen et al.   Cell and Bioscience

Vacuolar ATPase-mediated sequestration of local anesthetics in swollen macroautophagosomes

(2010) Marie-Thérèse Bawolak et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Quantitative Structure Activity Relationship for Inhibition of Human Organic Cation/Carnitine Transporter

(2010) Lei Diao et al.   MOLECULAR PHARMACEUTICS

Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology

(2009) G Morissette et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vacuolar ATPase-Mediated Cellular Concentration and Retention of Quinacrine: A Model for the Distribution of Lipophilic Cationic Drugs to Autophagic Vacuoles

(2009) F. Marceau et al.   DRUG METABOLISM AND DISPOSITION

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

(2009) M. Rossi et al.   JOURNAL OF CELL SCIENCE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Lack of direct interaction between enalaprilat and the kinin B1 receptors

(2008) Guillaume Morissette et al.   PEPTIDES

Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: Procainamide-induced autophagic cell vacuolization

(2008) Guillaume Morissette et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY