Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides

Comparative Molecular Dynamics Study of Human Islet Amyloid Polypeptide (IAPP) and Rat IAPP Oligomers

(2013) Guizhao Liang et al.   BIOCHEMISTRY

Extensive amyloid formation in transplanted microencapsulated mouse and human islets

(2012) Sara Bohman et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation

(2012) Michele F. M. Sciacca et al.   BIOCHEMISTRY

Probing ion channel activity of human islet amyloid polypeptide (amylin)

(2012) Jun Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A mechanistic insight into the amyloidogenic structure of hIAPP peptide revealed from sequence analysis and molecular dynamics simulation

(2012) Sandipan Chakraborty et al.   BIOPHYSICAL CHEMISTRY

Conformational dynamics of human IAPP monomers

(2012) Ronan D. Murphy et al.   BIOPHYSICAL CHEMISTRY

Role of β-Hairpin Formation in Aggregation: The Self-Assembly of the Amyloid-β(25–35) Peptide

(2012) Luca Larini et al.   BIOPHYSICAL JOURNAL

Structural Effects of L16Q, S20G, and L16Q-S20G Mutations on hIAPP: A Comparative Molecular Dynamics Study

(2012) Mian Wang et al.   CHINESE JOURNAL OF CHEMISTRY

The Effect of Aβ on IAPP Aggregation in the Presence of an Isolated β-Cell Membrane

(2012) Janine Seeliger et al.   JOURNAL OF MOLECULAR BIOLOGY

Computational and Experimental Analyses Reveal the Essential Roles of Interdomain Linkers in the Biological Function of Chemotaxis Histidine Kinase CheA

(2012) Xiqing Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fibril formation and toxicity of the non-amyloidogenic rat amylin peptide

(2012) Nathaniel G.N. Milton et al.   MICRON

Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor

(2012) Chris T. Middleton et al.   Nature Chemistry

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

(2011) Ravi Prakash Reddy Nanga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular Origin of Gerstmann-Sträussler-Scheinker Syndrome: Insight from Computer Simulation of an Amyloidogenic Prion Peptide

(2011) Isabella Daidone et al.   BIOPHYSICAL JOURNAL

Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20

(2011) Ping Cao et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Thermodynamics of Amylin Dimer Studied by Hamiltonian-Temperature Replica Exchange Molecular Dynamics Simulations

(2011) Rozita Laghaei et al.   JOURNAL OF PHYSICAL CHEMISTRY B

2DIR Spectroscopy of Human Amylin Fibrils Reflects Stable β-Sheet Structure

(2011) Lu Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces

(2011) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

Stable and Metastable States of Human Amylin in Solution

(2010) Allam S. Reddy et al.   BIOPHYSICAL JOURNAL

Solution Structures of Rat Amylin Peptide: Simulation, Theory, and Experiment

(2010) Allam S. Reddy et al.   BIOPHYSICAL JOURNAL

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

(2010) G. J. S. Cooper et al.   DIABETOLOGIA

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of G33A and G33I Mutations on the Structures of Monomer and Dimer of the Amyloid-β Fragment 29−42 by Replica Exchange Molecular Dynamics Simulations

(2010) Yan Lu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Unfolded-State Dynamics and Structure of Protein L Characterized by Simulation and Experiment

(2010) Vincent A. Voelz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Simulation ofab InitioProtein Folding for a Millisecond Folder NTL9(1−39)

(2010) Vincent A. Voelz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combination of Kinetically Selected Inhibitorsin TransLeads to Highly Effective Inhibition of Amyloid Formation

(2010) Fanling Meng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural diversity of dimers of the Alzheimer amyloid-β(25–35) peptide and polymorphism of the resulting fibrils

(2010) Guanghong Wei et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

(2010) K. J. Potter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta-cell selective KATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity

(2010) Robert A. Ritzel et al.   REGULATORY PEPTIDES

On the Origins of the Weak Folding Cooperativity of a Designed ββα Ultrafast Protein FSD-1

(2010) Chun Wu et al.   PLoS Computational Biology

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

The Ability of Rodent Islet Amyloid Polypeptide To Inhibit Amyloid Formation by Human Islet Amyloid Polypeptide Has Important Implications for the Mechanism of Amyloid Formation and the Design of Inhibitors

(2009) Ping Cao et al.   BIOCHEMISTRY

Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice

(2009) J. F. Aitken et al.   DIABETES

Importance of Aggregated Islet Amyloid Polypeptide for the Progressive Beta-Cell Failure in Type 2 Diabetes and in Transplanted Human Islets

(2009) Gunilla T. Westermark et al.   Experimental Diabetes Research

How accurate are continuum solvation models for drug-like molecules?

(2009) Jacob Kongsted et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The Structure of Aβ42 C-Terminal Fragments Probed by a Combined Experimental and Theoretical Study

(2009) Chun Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

(2009) Ravi Prakash Reddy Nanga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elucidating the Mechanism of Lipid Membrane-Induced IAPP Fibrillogenesis and Its Inhibition by the Red Wine Compound Resveratrol: A Synchrotron X-ray Reflectivity Study

(2009) Florian Evers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligomers of the Prion Protein Fragment 106−126 Are Likely Assembled from β-Hairpins in Solution, and Methionine Oxidation Inhibits Assembly without Altering the Peptide’s Monomeric Conformation

(2009) Megan Grabenauer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution state structures of human pancreatic amylin and pramlintide

(2009) John R. Cort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State†

(2008) Isaac T. Yonemoto et al.   BIOCHEMISTRY

Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19in Micelles by NMR Spectroscopy†

(2008) Ravi Prakash Reddy Nanga et al.   BIOCHEMISTRY

A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†

(2008) Jeffrey R. Brender et al.   BIOCHEMISTRY

Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

(2008) J. Udayasankar et al.   DIABETOLOGIA

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Amyloid β-Protein Monomer Folding: Free-Energy Surfaces Reveal Alloform-Specific Differences

(2008) Mingfeng Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid-β(29−42) Dimer Formations Studied by a Multicanonical−Multioverlap Molecular Dynamics Simulation

(2008) Satoru G. Itoh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Test on Peptide Stability of AMBER Force Fields with Implicit Solvation

(2008) M. Scott Shell et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets

(2008) Gunilla T. Westermark et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

(2008) J. D. Roth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamics and dynamics of amyloid peptide oligomerization are sequence dependent

(2008) Yan Lu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

On the nucleation of amyloid β-protein monomer folding

(2005) Noel D. Lazo et al.   PROTEIN SCIENCE