Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir
出版年份 2011 全文链接
标题
Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir
作者
关键词
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出版物
PLoS Computational Biology
Volume 7, Issue 4, Pages e1002037
出版商
Public Library of Science (PLoS)
发表日期
2011-04-29
DOI
10.1371/journal.pcbi.1002037
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans
- (2010) John P. Plastaras et al. CANCER BIOLOGY & THERAPY
- Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis
- (2010) S. Iadevaia et al. CANCER RESEARCH
- Molecular Dynamics Simulations of 2-Amino-6-arylsulphonylbenzonitriles Analogues as HIV Inhibitors: Interaction Modes and Binding Free Energies
- (2010) Rongjing Hu et al. Chemical Biology & Drug Design
- Drug–target residence time: critical information for lead optimization
- (2010) Hao Lu et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Teaching old receptors new tricks: biasing seven-transmembrane receptors
- (2010) Sudarshan Rajagopal et al. NATURE REVIEWS DRUG DISCOVERY
- In-Silico Approaches to Multi-target Drug Discovery
- (2010) Xiao Hua Ma et al. PHARMACEUTICAL RESEARCH
- Gatekeeper Mutations Mediate Resistance to BRAF-Targeted Therapies
- (2010) S. Whittaker et al. Science Translational Medicine
- A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology
- (2010) Jacob D. Durrant et al. PLoS Computational Biology
- Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
- (2010) Roger L. Chang et al. PLoS Computational Biology
- Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets
- (2010) Silpa Suthram et al. PLoS Computational Biology
- Quantitative Prediction of Fold Resistance for Inhibitors of EGFR
- (2009) Trent E. Balius et al. BIOCHEMISTRY
- A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery
- (2009) L. Xie et al. BIOINFORMATICS
- Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye
- (2009) Yue Wu et al. BMC DEVELOPMENTAL BIOLOGY
- Studies of chirality effect of 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine on p38α by molecular dynamics simulations and free energy calculations
- (2009) Quan Chen et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Molecular modeling of human cytochrome P450 2W1 and its interactions with substrates
- (2009) Weihua Li et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Importance of Ligand Reorganization Free Energy in Protein−Ligand Binding-Affinity Prediction
- (2009) Chao-Yie Yang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Predicting new molecular targets for known drugs
- (2009) Michael J. Keiser et al. NATURE
- Mechanisms of drug combinations: interaction and network perspectives
- (2009) Jia Jia et al. NATURE REVIEWS DRUG DISCOVERY
- Diversity and Complexity in DNA Recognition by Transcription Factors
- (2009) G. Badis et al. SCIENCE
- Binding of Small-Molecule Ligands to Proteins: “What You See” Is Not Always “What You Get”
- (2009) David L. Mobley et al. STRUCTURE
- Conciliating binding efficiency and polypharmacology
- (2009) Jordi Mestres et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Investigation of the Interaction between the Large and Small Subunits of Potato ADP-Glucose Pyrophosphorylase
- (2009) Ibrahim Barıs et al. PLoS Computational Biology
- Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis
- (2009) Sarah L. Kinnings et al. PLoS Computational Biology
- Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors
- (2009) Li Xie et al. PLoS Computational Biology
- From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage
- (2008) S. Giordano et al. CURRENT MEDICINAL CHEMISTRY
- Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis
- (2008) S. Maddika et al. JOURNAL OF CELL SCIENCE
- Kinase-likeness and Kinase-Privileged Fragments: Toward Virtual Polypharmacology
- (2008) Alex M. Aronov et al. JOURNAL OF MEDICINAL CHEMISTRY
- Anti-HIV drugs for cancer therapeutics: back to the future?
- (2008) Warren A Chow et al. LANCET ONCOLOGY
- Finding multiple target optimal intervention in disease-related molecular network
- (2008) Kun Yang et al. Molecular Systems Biology
- Models from experiments: combinatorial drug perturbations of cancer cells
- (2008) Sven Nelander et al. Molecular Systems Biology
- Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
- (2008) Beth Apsel et al. Nature Chemical Biology
- Network pharmacology: the next paradigm in drug discovery
- (2008) Andrew L Hopkins Nature Chemical Biology
- Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments
- (2008) L. Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
- (2008) T. Walsh et al. SCIENCE
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
- (2008) S. Jones et al. SCIENCE
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
- Repositioning HIV protease inhibitors as cancer therapeutics
- (2008) Wendy B Bernstein et al. Current Opinion in HIV and AIDS
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