How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare EffectiveNeisseria meningitidisVaccines

Neisseria meningitidis: pathogenesis and immunity

(2015) Mariagrazia Pizza et al.   CURRENT OPINION IN MICROBIOLOGY

Cellular and molecular biology ofNeisseria meningitidiscolonization and invasive disease

(2015) Darryl J. Hill et al.   CLINICAL SCIENCE

The Genetics ofNeisseriaSpecies

(2014) Ella Rotman et al.   Annual Review of Genetics

Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences

(2014) Mirka E Wörmann et al.   BMC GENOMICS

Immunological memory within the innate immune system

(2014) J. C. Sun et al.   EMBO JOURNAL

The meningococcal autotransporter AutA is implicated in autoaggregation and biofilm formation

(2014) Jesús Arenas et al.   ENVIRONMENTAL MICROBIOLOGY

Neisseriaproteomics for antigen discovery and vaccine development

(2014) Myron Christodoulides   Expert Review of Proteomics

Neisseria meningitidisB vaccines: recent advances and possible immunization policies

(2014) Roberto Gasparini et al.   Expert Review of Vaccines

Phase Variation Mediates Reductions in Expression of Surface Proteins during Persistent Meningococcal Carriage

(2014) M. Alamro et al.   INFECTION AND IMMUNITY

Inhibition of the Alternative Pathway of Nonhuman Infant Complement by Porin B2 Contributes to Virulence of Neisseria meningitidis in the Infant Rat Model

(2014) L. A. Lewis et al.   INFECTION AND IMMUNITY

Recombinant Protein Truncation Strategy for Inducing Bactericidal Antibodies to the Macrophage Infectivity Potentiator Protein of Neisseria meningitidis and Circumventing Potential Cross-Reactivity with Human FK506-Binding Proteins

(2014) Magdalena K. Bielecka et al.   INFECTION AND IMMUNITY

Molecular and Serological Diversity of Neisseria meningitidis Carrier Strains Isolated from Italian Students Aged 14 to 22 Years

(2014) R. Gasparini et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Inhibition of the Classical Pathway of Complement by Meningococcal Capsular Polysaccharides

(2014) Sarika Agarwal et al.   JOURNAL OF IMMUNOLOGY

Identification of vaccine antigens using integrated proteomic analyses of surface immunogens from serogroup B Neisseria meningitidis

(2014) Nikos Tsolakos et al.   Journal of Proteomics

The role and regulation of catalase in respiratory tract opportunistic bacterial pathogens

(2014) Mia M. Eason et al.   MICROBIAL PATHOGENESIS

Protectome Analysis: A New Selective Bioinformatics Tool for Bacterial Vaccine Candidate Discovery

(2014) Emrah Altindis et al.   MOLECULAR & CELLULAR PROTEOMICS

Recombinant Neisseria surface protein A is a potential vaccine candidate against Neisseria meningitides serogroup B

(2014) SHANGYUN YING et al.   Molecular Medicine Reports

Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization

(2014) Sandra C Bernard et al.   NATURE MEDICINE

The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin

(2014) Susannah Piek et al.   PLoS One

Genetic Diversity and Levels of Expression of Factor H Binding Protein among Carriage Isolates of Neisseria meningitidis

(2014) Ludovic Lemée et al.   PLoS One

Role of ARF6, Rab11 and External Hsp90 in the Trafficking and Recycling of Recombinant-Soluble Neisseria meningitidis Adhesin A (rNadA) in Human Epithelial Cells

(2014) Giuseppe Bozza et al.   PLoS One

Antibody and memory CD4+ T-cell responses after meningococcal disease

(2014) Aline C. Cruz et al.   VACCINE

A randomized, phase 1/2 trial of the safety, tolerability, and immunogenicity of bivalent rLP2086 meningococcal B vaccine in healthy infants

(2014) Federico Martinon-Torres et al.   VACCINE

The Hypervariable Region of Meningococcal Major Pilin PilE Controls the Host Cell Response via Antigenic Variation

(2014) F. Miller et al.   mBio

Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires

(2014) Eleanor R. Watkins et al.   Scientific Reports

Metabolism and virulence in Neisseria meningitidis

(2014) Christoph Schoen et al.   Frontiers in Cellular and Infection Microbiology

CRISPR-Cas systems: new players in gene regulation and bacterial physiology

(2014) Timothy R. Sampson et al.   Frontiers in Cellular and Infection Microbiology

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Substrate recognition of a structure motif for phosphorylcholine post-translational modification in Neisseria meningitidis

(2013) Freda E.-C. Jen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional genomics studies of the human pathogen Neisseria meningitidis

(2013) E. Del Tordello et al.   Briefings in Functional Genomics

Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins

(2013) Stefania Galdiero et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: A new perspective for vaccine development

(2013) T. Fiebig et al.   GLYCOBIOLOGY

Serogroup-Specific Interaction of Neisseria meningitidis Capsular Polysaccharide with Host Cell Microtubules and Effects on Tubulin Polymerization

(2013) Adelfia Talà et al.   INFECTION AND IMMUNITY

Transcriptional Profiling of Neisseria meningitidis Interacting with Human Epithelial Cells in a Long-TermIn VitroColonization Model

(2013) Ariann Hey et al.   INFECTION AND IMMUNITY

Ght Protein of Neisseria meningitidis Is Involved in the Regulation of Lipopolysaccharide Biosynthesis

(2013) F. Putker et al.   JOURNAL OF BACTERIOLOGY

Importance of Inhibition of Binding of Complement Factor H for Serum Bactericidal Antibody Responses to Meningococcal Factor H-binding Protein Vaccines

(2013) Monica Konar et al.   JOURNAL OF INFECTIOUS DISEASES

Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with routine infant and child vaccinations: results of two randomised trials

(2013) Timo Vesikari et al.   LANCET

Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment

(2013) Ulrich Vogel et al.   LANCET INFECTIOUS DISEASES

Identification of the immunoproteome of the meningococcus by cell surface immunoprecipitation and MS

(2013) J. Newcombe et al.   MICROBIOLOGY-SGM

In vitroresistance mechanisms ofNeisseria meningitidisagainst neutrophil extracellular traps

(2013) Martin Lappann et al.   MOLECULAR MICROBIOLOGY

Temperature triggers immune evasion by Neisseria meningitidis

(2013) Edmund Loh et al.   NATURE

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

(2013) Kevin M Esvelt et al.   NATURE METHODS

Use of a Molecular Decoy to Segregate Transport from Antigenicity in the FrpB Iron Transporter from Neisseria meningitidis

(2013) Muhammad Saleem et al.   PLoS One

An Analysis of the Sequence Variability of Meningococcal fHbp, NadA and NHBA over a 50-Year Period in the Netherlands

(2013) Stefania Bambini et al.   PLoS One

The Distribution and ‘In Vivo’ Phase Variation Status of Haemoglobin Receptors in Invasive Meningococcal Serogroup B Disease: Genotypic and Phenotypic Analysis

(2013) Jay Lucidarme et al.   PLoS One

Evaluation of Truncated NhhA Protein as a Candidate Meningococcal Vaccine Antigen

(2013) Ian R. Peak et al.   PLoS One

Prevalence and Phase Variable Expression Status of Two Autotransporters, NalP and MspA, in Carriage and Disease Isolates of Neisseria meningitidis

(2013) Neil J. Oldfield et al.   PLoS One

KpsC and KpsS are retaining 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferases involved in synthesis of bacterial capsules

(2013) L. M. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X

(2013) F. Micoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations

(2013) Serena Giuntini et al.   VACCINE

A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults

(2013) Helen S. Marshall et al.   VACCINE

Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): Lessons from past programs and implications for the future

(2013) Johan Holst et al.   Human Vaccines & Immunotherapeutics

Potential impact of the bivalent rLP2086 vaccine onNeisseria meningitidiscarriage and invasive serogroup B disease

(2013) Annaliesa S. Anderson et al.   Human Vaccines & Immunotherapeutics

Zinc Piracy as a Mechanism of Neisseria meningitidis for Evasion of Nutritional Immunity

(2013) Michiel Stork et al.   PLoS Pathogens

In Vivo Adaptation and Persistence of Neisseria meningitidis within the Nasopharyngeal Mucosa

(2013) Kay O. Johswich et al.   PLoS Pathogens

A Glutathione-Dependent Detoxification System Is Required for Formaldehyde Resistance and Optimal Survival of Neisseria meningitidis in Biofilms

(2012) Nathan H. Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

The Meningococcal Minor Pilin PilX Is Responsible for Type IV Pilus Conformational Changes Associated with Signaling to Endothelial Cells

(2012) Terry Brissac et al.   INFECTION AND IMMUNITY

Invasive Potential of Nonencapsulated Disease Isolates of Neisseria meningitidis

(2012) Kay O. Johswich et al.   INFECTION AND IMMUNITY

Meningococcal PilV Potentiates Neisseria meningitidis Type IV Pilus-Mediated Internalization into Human Endothelial and Epithelial Cells

(2012) Hideyuki Takahashi et al.   INFECTION AND IMMUNITY

A bacterial siren song: intimate interactions between Neisseria and neutrophils

(2012) Alison K. Criss et al.   NATURE REVIEWS MICROBIOLOGY

Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor

(2012) Hao-Ching Wang et al.   NUCLEIC ACIDS RESEARCH

Meningococcal Outer Membrane Protein NhhA Triggers Apoptosis in Macrophages

(2012) Mikael Sjölinder et al.   PLoS One

Opc Expression, LPS Immunotype Switch and Pilin Conversion Contribute to Serum Resistance of Unencapsulated Meningococci

(2012) Kerstin Hubert et al.   PLoS One

Recombinant outer membrane secretin PilQ406–770 as a vaccine candidate for serogroup B Neisseria meningitidis

(2012) Fakhri Haghi et al.   VACCINE

Caspase-1: is IL-1 just the tip of the ICEberg?

(2012) A Denes et al.   Cell Death & Disease

Single Nucleotide Polymorphisms in TLR9 Are Highly Associated with Susceptibility to Bacterial Meningitis in Children

(2011) M. S. Sanders et al.   CLINICAL INFECTIOUS DISEASES

Neisseria meningitidisB vaccines

(2011) Donatella Panatto et al.   Expert Review of Vaccines

Early clinical experience with a candidate meningococcal B recombinant vaccine (rMenB) in healthy adults

(2011) Daniela Toneatto et al.   Human vaccines & immunotherapeutics

Preclinical evidence for the potential of a bivalent fHBP vaccine to preventNeisseria meningitidisSerogroup C Disease

(2011) Shannon L. Harris et al.   Human vaccines & immunotherapeutics

Meningococcal glycoconjugate vaccines

(2011) Roberto Gasparini et al.   Human vaccines & immunotherapeutics

Characterization of FarR as a highly specialized, growth phase-dependent transcriptional regulator in Neisseria meningitidis

(2011) Stephanie Schielke et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

In the NadR Regulon, Adhesins and Diverse Meningococcal Functions Are Regulated in Response to Signals in Human Saliva

(2011) L. Fagnocchi et al.   JOURNAL OF BACTERIOLOGY

Neisseria meningitidisAdhesin NadA Targets β1 Integrins

(2011) Virginie Nägele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Blocking Human IgG Directed against the Pentapeptide Repeat Motifs of Neisseria meningitidis Lip/H.8 and Laz Lipoproteins

(2011) T. Dutta Ray et al.   JOURNAL OF IMMUNOLOGY

The role of catalase in gonococcal resistance to peroxynitrite

(2011) S. A. Spence et al.   MICROBIOLOGY-SGM

Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence

(2011) I. Tauseef et al.   MICROBIOLOGY-SGM

Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst

(2011) Adelfia Talà et al.   MOLECULAR MICROBIOLOGY

Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance

(2011) Natalie J. Griffiths et al.   MOLECULAR MICROBIOLOGY

Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria

(2011) Laty A. Cahoon et al.   MOLECULAR MICROBIOLOGY

Genotypic and Phenotypic Modifications of Neisseria meningitidis after an Accidental Human Passage

(2011) Hélène Omer et al.   PLoS One

Virulence Evolution of the Human Pathogen Neisseria meningitidis by Recombination in the Core and Accessory Genome

(2011) Biju Joseph et al.   PLoS One

Posttranslational Modification of Pili upon Cell Contact Triggers N. meningitidis Dissemination

(2011) J. Chamot-Rooke et al.   SCIENCE

The Transposon-Like Correia Elements Encode Numerous Strong Promoters and Provide a Potential New Mechanism for Phase Variation in the Meningococcus

(2011) Azeem Siddique et al.   PLoS Genetics

Transcriptome Analysis of Neisseria meningitidis in Human Whole Blood and Mutagenesis Studies Identify Virulence Factors Involved in Blood Survival

(2011) Hebert Echenique-Rivera et al.   PLoS Pathogens

Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation

(2011) Luciana M Hollanda et al.   JOURNAL OF NANOBIOTECHNOLOGY

Effects of multi-walled carbon nanotubes (MWCNT) under Neisseria meningitidis transformation process

(2011) Ives B Mattos et al.   JOURNAL OF NANOBIOTECHNOLOGY

Meningococcus Hijacks a β2-Adrenoceptor/β-Arrestin Pathway to Cross Brain Microvasculature Endothelium

(2010) Mathieu Coureuil et al.   CELL

NalP-Mediated Proteolytic Release of Lactoferrin-Binding Protein B from the Meningococcal Cell Surface

(2010) V. Roussel-Jazede et al.   INFECTION AND IMMUNITY

Meningococcal Internalization into Human Endothelial and Epithelial Cells Is Triggered by the Influx of Extracellular l-Glutamate via GltT l-Glutamate ABC Transporter inNeisseria meningitidis

(2010) Hideyuki Takahashi et al.   INFECTION AND IMMUNITY

Frequency and Rate of Pilin Antigenic Variation of Neisseria meningitidis

(2010) R. A. Helm et al.   JOURNAL OF BACTERIOLOGY

The Role of the Exopolyphosphatase PPX in Avoidance byNeisseria meningitidisof Complement-mediated Killing

(2010) Qian Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Population Structure and Capsular Switching of InvasiveNeisseria meningitidisIsolates in the Pre–Meningococcal Conjugate Vaccine Era—United States, 2000–2005

(2010) Lee H. Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2

(2010) Susu M. Zughaier   JOURNAL OF LEUKOCYTE BIOLOGY

The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes

(2010) Yogitha N. Srikhanta et al.   NATURE REVIEWS MICROBIOLOGY

The Influence of IS1301 in the Capsule Biosynthesis Locus on Meningococcal Carriage and Disease

(2010) Elisabeth Kugelberg et al.   PLoS One

Genome Sequencing Reveals Widespread Virulence Gene Exchange among Human Neisseria Species

(2010) Pradeep Reddy Marri et al.   PLoS One

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans

(2010) Davide Serruto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico CD4+ T-cell epitope prediction and HLA distribution analysis for the potential proteins of Neisseria meningitidis Serogroup B—A clue for vaccine development

(2010) Shishir K. Gupta et al.   VACCINE

The structure of a reduced form of OxyR from Neisseria meningitidis

(2010) Sarah Sainsbury et al.   BMC STRUCTURAL BIOLOGY

Structural Alterations in a Component of Cytochrome c Oxidase and Molecular Evolution of Pathogenic Neisseria in Humans

(2010) Marina Aspholm et al.   PLoS Pathogens

Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis

(2009) Jay R. Laver et al.   FASEB JOURNAL

The RNA Chaperone Hfq Is Involved in Stress Response and Virulence in Neisseria meningitidis and Is a Pleiotropic Regulator of Protein Expression

(2009) L. Fantappie et al.   INFECTION AND IMMUNITY

Evidence for Capsule Switching between Carried and Disease-Causing Neisseria meningitidis Strains

(2009) A. J. Beddek et al.   INFECTION AND IMMUNITY

The Meningococcal ABC-Type L-Glutamate Transporter GltT Is Necessary for the Development of Experimental Meningitis in Mice

(2009) R. Colicchio et al.   INFECTION AND IMMUNITY

Role of HrpA in Biofilm Formation of Neisseria meningitidis and Regulation of the hrpBAS Transcripts

(2009) R. B. Neil et al.   INFECTION AND IMMUNITY

Structural and Kinetic Characterizations of the Polysialic AcidO-Acetyltransferase OatWY fromNeisseria meningitidis

(2009) Ho Jun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

(2009) Carlos J. Orihuela et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of avoidance of host immunity by Neisseria meningitidis and its effect on vaccine development

(2009) Helena Lo et al.   LANCET INFECTIOUS DISEASES

Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria

(2009) K. R. Barth et al.   MICROBIOLOGY-SGM

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

(2009) Muriel C. Schneider et al.   NATURE

Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium

(2009) Mathieu Coureuil et al.   SCIENCE

Genome flexibility in Neisseria meningitidis

(2009) Christoph Schoen et al.   VACCINE

Meningococcal interactions with the host

(2009) Etienne Carbonnelle et al.   VACCINE

Meningococcal C conjugate vaccine: The experience in England and Wales

(2009) Helen Campbell et al.   VACCINE

A Novel Phase Variation Mechanism in the Meningococcus Driven by a Ligand-Responsive Repressor and Differential Spacing of Distal Promoter Elements

(2009) Matteo M. E. Metruccio et al.   PLoS Pathogens

Vaccine-Induced Opsonophagocytic Immunity to Neisseria meningitidis Group B

(2008) J. S. Plested et al.   Clinical and Vaccine Immunology

Molecular surveillance of Neisseria meningitidis capsular switching in Portugal, 2002–2006

(2008) M. J. SIMÕES et al.   EPIDEMIOLOGY AND INFECTION

Molecular characterization of nitrite reductase gene (aniA) and gene product inNeisseria meningitidisisolates: IsaniA essential for meningococcal survival?

(2008) Paola Stefanelli et al.   IUBMB LIFE

The Nitric Oxide (NO)-Sensing Repressor NsrR of Neisseria meningitidis Has a Compact Regulon of Genes Involved in NO Synthesis and Detoxification

(2008) K. Heurlier et al.   JOURNAL OF BACTERIOLOGY

Opa Protein Repertoires of Disease-Causing and Carried Meningococci

(2008) M. J. Callaghan et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A generic mechanism inNeisseria meningitidisfor enhanced resistance against bactericidal antibodies

(2008) Maria Jose Uria et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human monocytes/macrophages are a target of Neisseria meningitidis Adhesin A (NadA)

(2008) Susanna Franzoso et al.   JOURNAL OF LEUKOCYTE BIOLOGY

OxyR tightly regulates catalase expression inNeisseria meningitidisthrough both repression and activation mechanisms

(2008) Raffaele Ieva et al.   MOLECULAR MICROBIOLOGY

Revisiting the host as a growth medium

(2008) Stacie A. Brown et al.   NATURE REVIEWS MICROBIOLOGY

Immunoproteomic identification of the hypothetical protein NMB1468 as a novel lipoprotein ubiquitous inNeisseria meningitidis with vaccine potential

(2008) Chi-An Hsu et al.   PROTEOMICS

Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing

(2008) Elisabeth Kugelberg et al.   VACCINE

Factor H and Neisserial pathogenesis

(2008) Jo Anne Welsch et al.   VACCINE

Discrimination between host and pathogens by the complement system

(2008) Michael K. Pangburn et al.   VACCINE