Article
Food Science & Technology
Tavila Tatiane Amorim Cavalcante, Marcia Beatriz Silva de Souza, Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fabiane Bianca Albuquerque Barbosa, Karolaine Oliveira Bentes, Eliane Campos Alves, Hedylamar Oliveira Marques, Monica Colombini, Suely Vilela Sampaio, Manuela Berto Pucca, Iran Mendonca da Silva, Luiz Carlos de Lima Ferreira, Vanderson de Souza Sampaio, Ana Maria Moura-da-Silva, Allyson Guimaraes Costa, Wuelton Marcelo Monteiro, Jacqueline Almeida Goncalves Sachett, Marco Aurelio Sartim
Summary: Bothrops snakebite envenomation is a significant health issue in the Brazilian Amazon. Secondary infections are common complications, which affect local manifestations and inflammatory response.
Review
Biochemistry & Molecular Biology
Tadej Petreski, Nejc Piko, Robert Ekart, Radovan Hojs, Sebastjan Bevc
Summary: Chronic kidney disease is a major health problem in modern society, with a continuously rising prevalence. Recent studies have identified novel markers and gained new insights into the pathogenesis of CKD. Further large-scale studies are needed to establish the role of these markers in clinical practice.
Article
Biochemistry & Molecular Biology
David M. M. Cauvi, Dennis Hawisher, Julia Derunes, Antonio De Maio
Summary: Phospholipids play important roles in cellular membranes, vesicles, and lipid nanoparticles. The presence of phospholipids can alter the transcriptome and proteome of cells, as well as modulate signaling pathways, leading to changes in cellular functions.
Review
Immunology
Priscilla Vilela dos Santos, Debora Nonato Miranda de Toledo, Debora Maria Soares de Souza, Tatiana Prata Menezes, Luiza Oliveira Perucci, Zolder Marinho Silva, Daniela Caldas Teixeira, Ed Wilson Rodrigues Vieira, Valter Ferreira de Andrade-Neto, Nathalia Sernizon Guimaraes, Andre Talvani
Summary: This study evaluated the available information on inflammatory and regulatory plasma mediators in pregnant women diagnosed with toxoplasmosis. Eight studies were included in the analysis, and the results showed that infected pregnant women had higher levels of IL-5, IL-6, IL-8, IL-17, CCL5, and IL-10 in their plasma. These findings suggest that the immune status of pregnant women determines the course of T. gondii infection, and the balance between inflammatory and regulatory cytokines mitigates the adverse effects on the placenta and fetus.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Sagar Paudel, Laxman Ghimire, Liliang Jin, Duane Jeansonne, Samithamby Jeyaseelan
Summary: This article summarizes the mechanisms of how the hematopoietic system increases neutrophil generation rapidly during acute infectious and inflammatory conditions. Recent studies have identified new concepts, including the direct sensing of pathogens by BM resident or sentinel hematopoietic stem and progenitor cells, the crosstalk between hematopoietic stem and progenitor cells, endothelial cells, and stromal cells, and the direct effects of newly discovered inflammatory molecules on hematopoietic stem and progenitor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vilim Molnar, Vid Matisic, Ivan Kodvanj, Roko Bjelica, Zeljko Jelec, Damir Hudetz, Eduard Rod, Fabijan Cukelj, Trpimir Vrdoljak, Dinko Vidovic, Mario Staresinic, Srecko Sabalic, Borut Dobricic, Tadija Petrovic, Darko Anticevic, Igor Boric, Rok Kosir, Ursula Prosenc Zmrzljak, Dragan Primorac
Summary: Osteoarthritis is a common cause of disability worldwide, affecting all joint tissues equally. The pathogenesis involves low-grade inflammation leading to an imbalance between anabolic and catabolic processes. The complex network of cytokines regulating these processes plays a central role in the development and progression of osteoarthritis, with concentrations of proinflammatory and anti-inflammatory cytokines varying based on disease stage and activity levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Tong Yue, Yu Shi, Sihui Luo, Jianping Weng, Yali Wu, Xueying Zheng
Summary: Diabetic retinopathy is a common complication of diabetes mellitus that is largely driven by inflammation. Understanding and elucidating the inflammation-related mechanisms is crucial for prevention and management of diabetic retinopathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Cameron D. Haydinger, Liam M. Ashander, Alwin Chun Rong Tan, Justine R. Smith
Summary: Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein that plays important roles in the immune system and is involved in various diseases. It mediates cellular adhesive interactions and is upregulated in inflammation. This review provides a comprehensive summary of the structure and regulation of ICAM1 gene and the ICAM-1 protein, discusses its functions in the immune system and diseases, and explores current therapeutics and future advancements.
Review
Endocrinology & Metabolism
Hiba Hasan, Sudhanshu Bhushan, Monika Fijak, Andreas Meinhardt
Summary: Infection and inflammation are relevant factors that can lead to male reproductive disorders, causing damage to the testis and affecting spermatogenesis and steroidogenesis. Increased levels of oxidative stress and pro-inflammatory cytokines negatively impact germ cells. The activation of inflammatory pathways is a common feature in male testicular disorders beyond established infectious/inflammatory cues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Ren-Jun Hsu, Wei-Chieh Yu, Guan-Ru Peng, Chih-Hung Ye, SuiYun Hu, Patrick Chun Theng Chong, Kah Yi Yap, Jamie Yu Chieh Lee, Wei-Chen Lin, Shu-Han Yu
Summary: This review focuses on the cytokine storm in COVID-19, discussing its pathological features and potential immunotherapeutic approaches. Using cytokines as diagnostic markers and proactively managing the cytokine storm can improve disease outcomes and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Mukti Shukla, Atul Garg, T. N. Dhole, Rachna Chaturvedi
Summary: Japanese encephalitis (JE) is a viral brain fever caused by Japanese encephalitis virus (JEV). Although effective vaccines against this deadly infection are available, JE remains the leading cause of epidemic viral encephalitis in children in South-east Asia. The lack of treatment options for JE might be due to incomplete understanding of the pathogenesis of the virus.
Article
Medicine, General & Internal
Briana K. Clifford, Nadeem O. Kaakoush, Nicodemus Tedla, David Goldstein, David Simar
Summary: This study aimed to compare the effects of high-intensity and low-intensity aerobic exercise on the inflammatory profile of cancer survivors. It found that both low-intensity and high-intensity exercise can positively modulate inflammatory markers. Scaling up low-intensity exercise over time may be more applicable and achievable for cancer survivor cohorts while still eliciting beneficial effects on systemic inflammation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Daca, Hanna Storoniak, Alicja Debska-Slizien, Mariusz Andrzej Kusztal, Magdalena Krajewska, Katarzyna Aleksandra Lisowska
Summary: Levels of IL-6, IL-8, IL-10, TNF, and MIG were significantly higher in the serum of AAV patients compared to healthy controls, while IL-1 beta levels were higher in healthy volunteers. Levels of IL-6, IL-10, IP-10, and MIG negatively correlated with eGFR levels, while IFN-alpha levels positively correlated with PR3-ANCA titre. Studying the association between these cytokines/chemokines levels and clinical symptoms of AAV may aid in diagnosis and predicting disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Kalu K. Asanka Sanjeewa, Kalahe H. I. N. M. Herath, Hye-Won Yang, Cheol Soo Choi, You-Jin Jeon
Summary: Fucoidans are sulfated heteropolysaccharides found in brown seaweeds and some marine invertebrates, with promising bioactive properties such as antioxidant, immunomodulatory, anti-inflammatory, antiobesity, antidiabetic, and anticancer properties. Controlled inflammatory responses are beneficial, but chronic inflammatory responses are often associated with the pathogenesis of various diseases.
Article
Ophthalmology
Md Huzzatul Mursalin, Phillip S. Coburn, Frederick C. Miller, Erin T. Livingston, Roger Astley, Michelle C. Callegan
Summary: The absence of CXCL2 or CXCL10 in Bacillus endophthalmitis resulted in retained retinal function and reduced inflammation. The absence of CXCL2 had a better clinical outcome than the absence of CXCL10. Using anti-CXCL2 and anti-CXCL10 limited inflammation during B. cereus endophthalmitis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Regina Tavano, Luca Gabrielli, Elisa Lubian, Chiara Fedeli, Silvia Visentin, Patrizia Polverino De Laureto, Giorgio Arrigoni, Alessandra Geffner-Smith, Fangfang Chen, Dmitri Simberg, Giulia Morgese, Edmondo M. Benetti, Linping Wu, Seyed Moein Moghimi, Fabrizio Mancin, Emanuele Papini
Article
Cardiac & Cardiovascular Systems
Giorgio Vescovo, Chiara Castellani, Marny Fedrigo, Grazia Maria Virzi, Giovanni Maria Vescovo, Regina Tavano, Michela Pozzobon, Annalisa Angelini
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Valeria Caponetti, Jakub W. Trzcinski, Andrea Cantelli, Regina Tavano, Emanuele Papini, Fabrizio Mancin, Marco Montalti
FRONTIERS IN CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Chiara Castellani, Marny Fedrigo, Regina Tavano, Rekha Cappellini, Chiara Fedeli, Maddalena Mognato, Mona M. A. Abdel-Mottaleb, Alf Lamprecht, Ionut Tudorancea, Vlad Porumb, Radu Iliescu, Annalisa Angelini, Emanuele Papini, Gabriel Dimofte
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Review
Pharmacology & Pharmacy
S. Moein Moghimi, Dmitri Simberg, Emanuele Papini, Z. Shadi Farhangrazi
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Review
Immunology
Emanuele Papini, Regina Tavano, Fabrizio Mancin
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Jakub W. Trzcinski, Lucia Morillas-Becerril, Sara Scarpa, Marco Tannorella, Francesco Muraca, Federico Rastrelli, Chiara Castellani, Marny Fedrigo, Annalisa Angelini, Regina Tavano, Emanuele Papini, Fabrizio Mancin
Summary: This study describes an innovative approach to produce biocompatible, degradable, and stealth polymeric nanoparticles based on poly(lipoic acid), stabilized by a PEG-ended surfactant. The nanoparticles showed high stability in biological media, minimal protein corona formation in biological fluids, and no acute toxicity in vitro and in vivo. They were also efficiently cleared from the organism and exhibited a preference for short-term accumulation in the heart, making them promising candidates for nanomedicine.
Article
Biochemistry & Molecular Biology
Chiara Bellini, Salvatore Antonucci, Lucia Morillas-Becerril, Sara Scarpa, Regina Tavano, Fabrizio Mancin, Fabio Di Lisa, Emanuele Papini
Summary: The study demonstrated the effectiveness of utilizing two formulations of poly(lipoic acid)-based nanoparticles (NPs) in combating radical damage and ROS formation in various cell types. Results indicate that NPs could effectively protect against myocardial cell damage induced by ischemic reperfusion injury.
Article
Multidisciplinary Sciences
Giorgio Vescovo, Chiara Castellani, Marny Fedrigo, Grazia Maria Virzi, Giovanni Maria Vescovo, Regina Tavano, Michela Pozzobon, Annalisa Angelini