Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Review
Cardiac & Cardiovascular Systems
Wenjing Li, Kehan Jin, Jichang Luo, Wenlong Xu, Yujie Wu, Jia Zhou, Yilin Wang, Ran Xu, Liqun Jiao, Tao Wang, Ge Yang
Summary: This review summarizes the interactions between the primary transcription factor NF-kappa B and endoplasmic reticulum stress (ER stress) in the progression of atherosclerosis (AS). NF-kappa B and ER stress play critical roles in the pathogenesis of AS and have overlapping molecular regulation and function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Wei Xiao, Zehui He, Weikang Luo, Dandan Feng, Yang Wang, Tao Tang, Ali Yang, Jiekun Luo
Summary: Intracerebral hemorrhage (ICH) induces inflammatory response that affects brain repair and organism recovery. Research suggests that Buyang Huanwu Decoction (BYHWD) can attenuate the inflammatory response during ICH recovery in rats by inhibiting the NIK-mediated noncanonical NF-kappa B signaling pathway, improving neurological function in rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yue Xia, Minghuan Ge, Ling Xia, Guang Shan, Huijun Qian
Summary: This study reveals that the aberrant expression of cathepsin V (CTSV) is associated with a poor outcome in bladder cancer patients. CTSV enhances the inflammatory reaction, thereby promoting the development of bladder cancer. Overexpression of CTSV increases the proliferation and viability of bladder cancer cells, while deletion of CTSV significantly inhibits their proliferation and viability. Furthermore, overexpression of CTSV activates the inflammatory signaling pathway, which can be restored by introducing an NF-kappa B inhibitor.
Article
Immunology
Ying Fu, Ying Wang, Yuxue Liu, Chengyuan Tang, Juan Cai, Guochun Chen, Zheng Dong
Summary: This study revealed the p53/SIRT1/NF-kappa B signaling axis in maladaptive kidney repair following repeated low-dose cisplatin injury. Activation of SIRT1 attenuated chronic inflammation and tissue damage in the kidney.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Wen Gao, Lin Guo, Yan Yang, Yu Wang, Shuang Xia, Hui Gong, Bi-Kui Zhang, Miao Yan
Summary: Nrf2 and NF-kappa B are important regulators of oxidative stress and inflammation in the body, and there is crosstalk between them. Drug-induced organ toxicity has become a focus of research in clinical practice, and it is urgent to find protective drugs to alleviate this injury. Evidence suggests that modulating both Nrf2 and NF-kappa B pathways can alleviate drug-induced organ toxicity. Therefore, exploring the crosstalk mechanism between Nrf2 and NF-kappa B is of great importance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Puhua Zhang, Chaolun Yu, Jianwen Yu, Zhijian Li, Hui-yao Lan, Qin Zhou
Summary: The lncRNA Arid2-IR plays a critical role in kidney diseases by regulating NF-kappa B signaling via a NLRC5-dependent mechanism, which can be inhibited by Filamin A in the cytoplasm. Targeting Arid2-IR may be a novel therapeutic strategy for inflammatory diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biology
Dongyang Wang, Xiaojing Zheng, Lihong Chai, Junli Zhao, Jiuling Zhu, Yanqing Li, Peiyan Yang, Qinwen Mao, Haibin Xia
Summary: In this study, the role of FAM76B in regulating neuroinflammation was demonstrated for the first time. It was shown that FAM76B could regulate the NF-kappa B-mediated inflammatory pathway by affecting hnRNPA2B1 translocation. This provides new insights into the mechanism of inflammation regulation.
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Anna L. Aalto, Atefeh Saadabadi, Fanny Lindholm, Christa Kietz, Emmy Himmelroos, Parthiban Marimuthu, Outi M. H. Salo-Ahen, Patrik Eklund, Annika Meinander
Summary: This study demonstrates the anti-inflammatory properties of stilbenoid compounds PS and PSMME in the intestine of fruit flies, and their potential to alleviate chemically induced intestinal inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Ting Du, Ying Long, Wei Tang, Xue-Feng Liu, Fang Dai, Bo Zhou
Summary: The study found that vitamin C can form an efficient redox cycle with intracellular glutathione and copper ions, generating reactive oxygen species (ROS), which in turn inhibits NF-kappa B-mediated inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sergio Davinelli, Luciano Saso, Floriana D'Angeli, Vittorio Calabrese, Mariano Intrieri, Giovanni Scapagnini
Summary: This article reviews the potential molecular mechanisms by which astaxanthin (AST) regulates the transcription factors Nrf2 and NF-κB, which are involved in oxidative stress and inflammation. Additionally, it summarizes the current clinical studies elucidating how AST alleviates the etiopathogenesis of oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Yali Yan, Gegentuya Bao, Jingyuan Pei, Ying Cao, Chenyu Zhang, Pengfei Zhao, Yantao Zhang, Alatangaole Damirin
Summary: The bioactive lipid S1P activates G-protein-coupled S1P receptors in RCC, with high expression of S1PR3 correlating to poor prognosis. S1P promotes proliferation and migration of renal cancer cells via the S1PR3 receptor, highlighting it as a potential therapeutic target for S1PR3-expressed cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Neurosciences
Jinwang Ye, Suyue Zhong, Yunsong Deng, Xuanbao Yao, Qiong Liu, Jian-Zhi Wang, Shifeng Xiao
Summary: Class IIa histone deacetylases (HDAC) play a role in inflammation by promoting IKK activation and subsequent NF-kappa B activation. In this study, HDAC7 was found to be elevated in astrocytes after LPS challenge, leading to NF-kappa B activation, pro-inflammatory gene upregulation, and anxiety-like behaviors. Inhibition of HDAC7 attenuated LPS-induced inflammation and anxiety-like behaviors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Oncology
Xuehua Sun, Xinyou Li, Youfei Zhou, Yufei Wang, Xiaochen Liu
Summary: TIPE2 plays a crucial role in inflammatory pain by suppressing inflammation induced by microglial activation, reducing the activation of the NF-κB pathway, thus alleviating pain and inflammatory responses.
EXPERIMENTAL CELL RESEARCH
(2021)
