Correction
Cell Biology
Ping Xie, Zhiqiang Peng, Yujiao Chen, Hongchang Li, Mengge Du, Yawen Tan, Xin Zhang, Zhe Lu, Chun-Ping Cui, Cui Hua Liu, Fuchu He, Lingqiang Zhang
Summary: Correction to the paper has been published.
Article
Toxicology
Onat Kadioglu, Mohamed Saeed, Nuha Mahmoud, Shaymaa Azawi, Kristin Mrasek, Thomas Liehr, Thomas Efferth
Summary: In this study, colon cancer cells with TP53 deletion were characterized, and multiple genes were found to be overexpressed, potentially influencing multidrug resistance. The research sheds light on unknown drug resistance mechanisms and may impact future treatment strategies.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Microbiology
Lei Qi, Ying-Xuan Zhu, Ye-Ke Wang, Xing-Xing Tang, Ke-Jing Li, Min He, Yang Sui, Pin-Mei Wang, Dao-Qiong Zheng, Ke Zhang
Summary: This study demonstrates that nonlethal concentrations of furfural in the culture medium can significantly induce genome instability in the yeast Saccharomyces cerevisiae. Furfural exposure increased chromosome aberrations and specific genomic alterations were identified that confer furfural tolerance to the yeast strain.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Jingyu Chen, Anketse Debebe, Ni Zeng, Janel Kopp, Lina He, Maike Sander, Bangyan L. Stiles
Summary: The research indicates that SOX9(+) cells play a crucial role in liver carcinogenesis, and the loss of gene PTEN induces the transformation of these cells. Liver injury is crucial for promoting the activation and proliferation of transformed SOX9(+) cells.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Shihui Guo, Xiao Zhu, Ziyuan Huang, Chuzhong Wei, Jiaao Yu, Lin Zhang, Jinghua Feng, Mingdong Li, Zesong Li
Summary: Genetic instability can be caused by external factors and is related to intracellular damage. Research has shown the connection between genomic stability and tumors, which is a crucial factor in tumor treatment. The mechanisms of genomic stability and tumorigenesis development are complex, but researchers have been making progress in these areas. This review introduces various aspects related to genomic stability, tumor development drivers, characteristics of tumor cells, tumor metastasis, and tumor treatment. Immunotherapy plays a significant role in tumor treatment as it can effectively inhibit tumor spread and eliminate tumor cells. Advances in tumorigenesis development studies and discoveries in tumor metastasis provide new therapeutic techniques that can prevent tumor spread and improve the cure rate of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Tala Tayoun, Marianne Oulhen, Agathe Aberlenc, Francoise Farace, Patrycja Pawlikowska
Summary: CTCs provide a tool for studying tumor heterogeneity and metastatic potential, with recent progress in single-cell analysis shedding light on genomic instability and its impact on tumor evolution and resistant clones emergence. Evaluating CIN and CNA in CTCs reveals their role in metastatic progression and resistance, despite technical obstacles in single CTC analysis, but showing potential predictive value for genotoxic treatment response.
Review
Biochemistry & Molecular Biology
Evgeny Imyanitov, Anna Sokolenko
Summary: In oncology practice, clinical decisions often rely on the detection of genetic alterations. Microsatellite instability (MSI) analysis identifies tumors with a high mutation rate, homologous repair deficiency (HRD) indicates tumor sensitivity to certain drugs, and tumor mutation burden (TMB) is a potential indicator of tumor response to immunotherapy. However, the applications of these tests in different cancer types require further research and standardization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan Hu, Chenyang Qi, Jiaoyu Shi, Weiqiang Tan, Zhonghua Zhao, Yanyong Xu, Huijuan Wu, Zhigang Zhang
Summary: UCHL1 deficiency leads to severe kidney damage and proteinuria in podocytes, which is associated with ER stress, protein accumulation, and cell apoptosis. UCHL1 may be a potential target for preventing non-immune complex-mediated glomerulopathy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Laurel A. Keefer, James R. White, Derrick E. Wood, Kelly M. R. Gerding, Kenneth C. Valkenburg, David Riley, Christopher Gault, Eniko Papp, Christine M. Vollmer, Amy Greer, James Hernandez, Paul M. McGregor, Adriana Zingone, Brid M. Ryan, Kristen Deak, Shannon J. McCall, Michael B. Datto, James L. Prescott, John F. Thompson, Gustavo C. Cerqueira, Sian Jones, John K. Simmons, Abigail McElhinny, Jennifer Dickey, Samuel Angiuoli, Luis A. Diaz, Victor E. Velculescu, Mark Sausen
Summary: This study describes a comprehensive genomic profiling assay with high analytical performance and provides validation of its accuracy and reliability using clinically and biologically relevant samples.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Fangfang Xu, Tingwei Liu, Zhuonan Zhou, Chang Zou, Shaohua Xu
Summary: The study identified APOBEC3A as a protective factor and a promising prognostic biomarker for forecasting the survival and immunotherapy effect of OC patients, potentially accelerating the clinical application and improving immunotherapy effect.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Robert C. Grant, Robert Denroche, Gun Ho Jang, Klaudia M. Nowak, Amy Zhang, Ayelet Borgida, Spring Holter, James T. Topham, Julie Wilson, Anna Dodd, Raymond Jang, Rebecca Prince, Joanna M. Karasinska, David F. Schaeffer, Yifan Wang, George Zogopoulos, Scott Berry, Diane Simeone, Daniel J. Renouf, Faiyaz Notta, Grainne O'Kane, Jennifer Knox, Sandra Fischer, Steven Gallinger
Summary: Patients with MMRD pancreatic cancer exhibit longer overall survival, distinct histopathological and genomic features, and may benefit from targeted therapies based on their unique genomic drivers.
Review
Oncology
Massimo Bonora, Sonia Missiroli, Mariasole Perrone, Francesco Fiorica, Paolo Pinton, Carlotta Giorgi
Summary: Cancer cells display genomic instability, with mitochondria playing a key role in responding to DNA alterations and affecting cell survival and the accumulation of mutations. Mitochondrial alterations in cancer can impact cell death pathways and metabolic plasticity, contributing to the evolution of the disease. Mitochondria are involved in regulating cell death and metabolic adaptation in tumor cells, and their role in supporting genomic instability in cancer is an important aspect that warrants further exploration.
Article
Pharmacology & Pharmacy
Kunyan He, Guang-Xing Wang, Li-Nan Zhao, Xiao-Fang Cui, Xian-Bin Su, Yi Shi, Tian-Pei Xie, Shang-Wei Hou, Ze-Guang Han
Summary: The compound cinobufagin extracted from Traditional Chinese Medicine showed potent inhibitory effects on the proliferation of cancer cells with EGFR amplification, leading to suppression of tumor growth in vivo. This discovery provides a new therapeutic option for treating malignant glioma and other human cancers expressing EGFR.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So Young Kang, Deok Geun Kim, Kyoung-Mee Kim
Summary: Detecting microsatellite instability (MSI) is crucial for clinical decision-making in advanced cancers. This study identified rare cases of BAT26-only instability, which is associated with PTEN protein loss, high tumor mutation burden (TMB), and a high PD-L1 score. These results suggest that patients with BAT26-only instability may show good responses to immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Badri Krishnan, Takaaki Yasuhara, Purva Rumde, Marcello Stanzione, Chenyue Lu, Hanjun Lee, Michael S. Lawrence, Lee Zou, Linda T. Nieman, Ioannis Sanidas, Nicholas J. Dyson
Summary: RB restricts G1/S progression by inhibiting E2F, but also affects chromosome architecture and cellular state. Expression of RB and G1 arrest leads to visible changes in chromosome structure, which are related to RB activity, specific isoforms of monophosphorylated RB, and known RB-associated activities. Delt ΔCK-RB alters physical interactions between genomic loci, but these changes are not affected by dominant-negative DN.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jinxue He, Xi Kang, Yuxin Yin, K. S. Clifford Chao, Wen H. Shen
NATURE COMMUNICATIONS
(2015)
Article
Multidisciplinary Sciences
Xi Kang, Chang Song, Xiao Du, Cong Zhang, Yu Liu, Ling Liang, Jinxue He, Kristy Lamb, Wen H. Shen, Yuxin Yin
SCIENTIFIC REPORTS
(2015)
Article
Cell Biology
Zhong Zhang, Sheng-Qi Hou, Jinxue He, Tingting Gu, Yuxin Yin, Wen H. Shen
Review
Biochemistry & Molecular Biology
Sonia Yu, Fan Yang, Wen H. Shen
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
Article
Multidisciplinary Sciences
Jinxue He, Zhong Zhang, Meng Ouyang, Fan Yang, Hongbo Hao, Kristy L. Lamb, Jingyi Yang, Yuxin Yin, Wen H. Shen
Nature Communications
(2016)
Article
Biochemistry & Molecular Biology
Andrew Brandmaier, Sheng-Qi Hou, Wen H. Shen
JOURNAL OF MOLECULAR BIOLOGY
(2017)
Article
Oncology
Zhuo Sun, Jinqi Lu, Muyu Wu, Mingyan Li, Lu Bai, Zhenduo Shi, Lin Hao, Yongping Wu
MOLECULAR MEDICINE REPORTS
(2019)
Article
Toxicology
Zhuo Sun, Mingyan Li, Lu Bai, Jiaju Fu, Jinqi Lu, Muyu Wu, Chen Zhou, Ying Zhang, Yongping Wu
TOXICOLOGY LETTERS
(2019)
Article
Oncology
Zhuo Sun, Jinqi Lu, Muyu Wu, Changli Ouyang, Yueping Xing, Xiancun Hou, Zhenduo Shi, Yongping Wu
Article
Biochemistry & Molecular Biology
Zhuo Sun, Yidan Cao, Yueping Xing, Muyu Wu, Xiaotong Shao, Qingli Huang, Lu Bai, Li Wang, Yaxian Zhao, Yongping Wu
Summary: Research found that ATO induces autophagy in HUVECs through upregulation of FoxO3a, which suppresses angiogenesis, highlighting the importance of autophagy in the antiangiogenic effect of ATO.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Urology & Nephrology
Zhuo Sun, Xiaotong Shao, Haotian Wu, Yaxian Zhao, Yidan Cao, Danhua Li, Ying Sun, Qingling Wang
Summary: It has been found that the PTEN gene plays an important role in normal kidney development and function. However, its role in renal tubular reabsorption function has not been well understood. By using a renal tubule-specific Pten knockout mouse model, it was found that Pten loss led to abnormal renal structure and function, as well as water retention in multiple organs. The upregulation and concentration of AQP2 on the apical plasma membrane of collecting duct cells, mediated by AKT activation, could be responsible for the impaired water balance in Pten loss mice.
Article
Multidisciplinary Sciences
Su-Lin Zeng, Suraj S. Patel, Mo-Qi Lv, Daphne Zhu, Wen H. Shen, Li Liu
Summary: In this study, the novel oncogene STYK1/NOK's role in cell division was investigated. It was found that STYK1/NOK interacts directly with CDH1 and can affect cell division by targeting key components of the APC/C pathway. These findings provide mechanistic clues for the understanding of STYK1/NOK's roles in mitosis and cytokinesis.
Review
Biochemistry & Molecular Biology
Sheng-Qi Hou, Meng Ouyang, Andrew Brandmaier, Hongbo Hao, Wen H. Shen
Article
Biochemistry & Molecular Biology
Wei-Ye Shi, Xiao Yang, Bo Huang, Wen H. Shen, Li Liu
FRONTIERS IN BIOSCIENCE-LANDMARK
(2017)