Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping

(2014) Qing Lou et al.   CIRCULATION

Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals

(2014) Yael Yaniv et al.   HEART RHYTHM

Biophysical Characterization of the Underappreciated and Important Relationship Between Heart Rate Variability and Heart Rate

(2014) Oliver Monfredi et al.   HYPERTENSION

Heart Rate Variability Findings as a Predictor of Atrial Fibrillation in Middle-Aged Population

(2014) JUHA PERKIÖMÄKI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells

(2014) Yael Yaniv et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modern Perspectives on Numerical Modeling of Cardiac Pacemaker Cell

(2014) Victor A. Maltsev et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking

(2014) Sathya D. Unudurthi et al.   Frontiers in Physiology

Heart Rate Variability and Procedural Outcome in Catheter Ablation for Atrial Fibrillation

(2013) Geoffrey E.J. Seaborn et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia

(2013) Sandra Hoffmann et al.   BASIC RESEARCH IN CARDIOLOGY

Mechanisms of Beat-to-Beat Regulation of Cardiac Pacemaker Cell Function by Ca2+ Cycling Dynamics

(2013) Yael Yaniv et al.   BIOPHYSICAL JOURNAL

Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function

(2013) Manuel Zarzoso et al.   CARDIOVASCULAR RESEARCH

The cardiac sodium–calcium exchanger NCX1 is a key player in the initiation and maintenance of a stable heart rhythm

(2013) Stefan Herrmann et al.   CARDIOVASCULAR RESEARCH

Sick Sinus Syndrome in HCN1-Deficient Mice

(2013) Stefanie Fenske et al.   CIRCULATION

RyR-NCX-SERCA Local Cross-Talk Ensures Pacemaker Cell Function at Rest and During the Fight-or-Flight Reflex

(2013) Anna V. Maltsev et al.   CIRCULATION RESEARCH

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1

(2013) Alexey V. Glukhov et al.   EUROPEAN HEART JOURNAL

Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm

(2013) Thomas Hof et al.   HEART RHYTHM

Pacemaker Gene Mutations, Bradycardia, Arrhythmias and the Coupled Clock Theory

(2013) YAEL YANIV et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Cyclical stretch induces structural changes in atrial myocytes

(2013) Anne Margreet De Jong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling

(2013) Yael Yaniv et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart

(2013) John Azer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity and Sinoatrial Nodal Pacemaker Cell Energetics

(2013) Yael Yaniv et al.   PLoS One

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

(2013) Oliver Monfredi et al.   PLoS One

Denervation as a Common Mechanism Underlying Different Pulmonary Vein Isolation Strategies for Paroxysmal Atrial Fibrillation: Evidenced by Heart Rate Variability after Ablation

(2013) Kejing Wang et al.   TheScientificWorldJOURNAL

Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice

(2012) M. J. Bround et al.   CARDIOVASCULAR RESEARCH

Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Patricia Neco et al.   CIRCULATION

Association of Heart Rate Variability With Arrhythmic Events in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

(2012) Irma Battipaglia et al.   CIRCULATION JOURNAL

Altered HCN4 channel C-linker interaction is associated with familial tachycardia–bradycardia syndrome and atrial fibrillation

(2012) Nana Duhme et al.   EUROPEAN HEART JOURNAL

Tachy-brady arrhythmias: The critical role of adenosine-induced sinoatrial conduction block in post-tachycardia pauses

(2012) Qing Lou et al.   HEART RHYTHM

Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+channels in mouse sinoatrial node

(2012) Carl J. Christel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Clinical Efficacy of Ivabradine in Patients With Inappropriate Sinus Tachycardia

(2012) Riccardo Cappato et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The “Funny” Current (If) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells

(2012) Yael Yaniv et al.   MOLECULES

Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18

(2012) Nidhi Kapoor et al.   NATURE BIOTECHNOLOGY

Functional roles of Cav1.3, Cav3.1 and HCN channels in automaticity of mouse atrioventricular cells

(2011) Laurine Marger et al.   Channels

Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation

(2011) Shane R. Cunha et al.   CIRCULATION

Risk markers of late high-degree atrioventricular block in patients with left ventricular dysfunction after an acute myocardial infarction: a CARISMA substudy

(2011) U. J. O. Gang et al.   EUROPACE

Functional Redundancy between HumanSHOXand MouseShox2Genes in the Regulation of Sinoatrial Node Formation and Pacemaking Function

(2011) Hongbing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Suppression of Connexin43 byTBX18Undermines Cell-Cell Electrical Coupling in Postnatal Cardiomyocytes

(2011) Nidhi Kapoor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beat-to-beat Ca2+-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm

(2011) Yael Yaniv et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca2+ clock malfunction in a canine model of pacing-induced heart failure

(2010) Tetsuji Shinohara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

V-Shaped Trough in Autonomic Activity Is a Possible Precursor of Life-Threatening Cardiac Events

(2010) Motohisa Osaka et al.   CIRCULATION JOURNAL

cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control

(2010) Patrick A. Schweizer et al.   Circulation-Arrhythmia and Electrophysiology

Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness

(2010) Shahid M Baig et al.   NATURE NEUROSCIENCE

Funny Current Downregulation and Sinus Node Dysfunction Associated With Atrial Tachyarrhythmia

(2009) Yung-Hsin Yeh et al.   CIRCULATION

Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction

(2009) H. V. Huikuri et al.   EUROPEAN HEART JOURNAL

Multiscale Analysis of Heart Rate Dynamics: Entropy and Time Irreversibility Measures

(2008) Madalena D. Costa et al.   Cardiovascular engineering (Dordrecht, Netherlands)

Ca2+-stimulated Basal Adenylyl Cyclase Activity Localization in Membrane Lipid Microdomains of Cardiac Sinoatrial Nodal Pacemaker Cells

(2008) Antoine Younes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

(2008) S. Le Scouarnec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA