Article
Biochemistry & Molecular Biology
Lourdes Alvarez-Sanchez, Carmen Pena-Bautista, Laura Ferre-Gonzalez, Angel Balaguer, Miguel Baquero, Bonaventura Casanova-Estruch, Consuelo Chafer-Pericas
Summary: This study analyzed plasma biomarkers (Amyloid beta 42, p-Tau181, t-Tau, neurofilament light (NfL), TAR DNA-binding protein 43 (TDP-43)) in AD and FTLD patients using single molecule array technology (SIMOA((R))). Plasma p-Tau181 correlated with CSF levels and showed good accuracy in distinguishing controls from AD, as well as discriminating AD from FTLD. Plasma NfL could discriminate dementia-AD vs. controls, FTLD vs. controls, and MCI-AD vs. dementia-AD. These biomarkers in plasma may be helpful for AD diagnosis and differentiating from FTLD, and potentially useful for future AD screening protocols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
James E. Galvin, Paul Aisen, Jessica B. Langbaum, Eric Rodriguez, Marwan Sabbagh, Richard Stefanacci, Robert A. Stern, Elizabeth A. Vassey, Arno de Wilde, Neva West, Ivana Rubino
Summary: Alzheimer's disease is a progressive neurodegenerative disease that poses complex challenges for patients and caregivers. Early and accurate diagnosis is crucial for optimizing outcomes, yet many patients in the early stages remain undiagnosed due to barriers in the diagnostic journey. International experts have collaborated to create a patient-centered diagnostic blueprint for individuals in the early stages of AD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ashley E. Tate, Vincent Bouteloup, Ingrid S. van Maurik, Delphine Jean, Arenda Mank, Andreja Speh, Valerie Boilet, Argonde van Harten, Maria Eriksdotter, Anders Wimo, Carole Dufouil, Wiesje M. van der Flier, Linus Joensson
Summary: This study aimed to determine the timeline from mild cognitive impairment (MCI) to death and found that the sojourn time was associated with age, gender, and disease diagnosis, providing important estimates for researchers and clinicians to predict prognosis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Nanet Willumsen, Teresa Poole, Jennifer M. Nicholas, Nick C. Fox, Natalie S. Ryan, Tammaryn Lashley
Summary: This study found significant heterogeneity in A beta pathology among familial Alzheimer's disease cases, with different mutations potentially leading to varying patterns of A beta deposition. Carriage of the APOE4 allele may be associated with increased disease duration but not age at onset.
Article
Clinical Neurology
E. Yetim, T. Gul, A. N. Basak, E. Saka
Summary: This case report describes a patient with a G131V mutation in the PRNP gene initially misdiagnosed as familial Alzheimer's disease. Genetic evaluation revealed the mutation, emphasizing the importance of genetic assessment in familial early-onset dementia patients regardless of clinical and imaging features.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Kevin Kuo, Ya-Ru Zhang, Shi-Dong Chen, Xiao-Yu He, Shu-Yi Huang, Bang-Sheng Wu, Yue-Ting Deng, Liu Yang, Ya-Nan Ou, Yu Guo, Rui-Qi Zhang, Yi Zhang, Lan Tan, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: This study analyzed data from the UK Biobank and found that a 5 kg increment in grip strength was associated with lower risks of all types of dementia, while a slow walking pace was associated with increased risks of all types of dementia. These findings highlight the importance of grip strength and walking pace in estimating the risks of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Jemma Hazan, Michelle Wing, Kathy Y. Liu, Suzanne Reeves, Robert Howard
Summary: This study evaluated the clinical utility of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease (AD) in patients with cognitive impairment. The meta-analysis showed that the use of CSF biomarkers led to changes in diagnosis, increased diagnostic confidence, and influenced patient management. Further research is needed to explore the clinical utility of blood-based biomarkers.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Unnur D. Teitsdottir, Skarphedinn Halldorsson, Ottar Rolfsson, Sigrun H. Lund, Maria K. Jonsdottir, Jon Snaedal, Petur H. Petersen
Summary: The study identified a significant association between elevated levels of C18 ceramide in cerebrospinal fluid and increased Alzheimer's disease pathology and inflammation, suggesting its potential value as a therapeutic target.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Nol Swaddiwudhipong, David J. Whiteside, Frank H. Hezemans, Duncan Street, James B. Rowe, Timothy Rittman
Summary: UK Biobank data reveals pre-diagnostic cognitive and functional decline in multiple neurodegenerative diseases years before symptoms appear. Identifying pre-diagnostic changes could enhance selection for preventive and early disease-modifying treatment trials.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Michaela Rice, Deana Davalos, Michael L. Thomas
Summary: Prospective memory is impaired in individuals with dementia-related disorders. This review examined 21 studies on intervention strategies for prospective memory and found that interventions can improve prospective memory abilities. However, there are concerns about ecological validity and lack of diversity in interventions across different stages of dementia-related disorders.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Health Care Sciences & Services
Jong-Hee Sohn, Jae Jun Lee, Sang-Hwa Lee, Chulho Kim, Hyunjae Yu, Young-Suk Kwon, Dong-Kyu Kim
Summary: The study based on Korean National Health Insurance Service data found a significant positive association between exposure to general anesthesia and dementia risk, especially Alzheimer's disease and vascular dementia, with higher risks for women and patients with comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Olivier Beauchet, Harmehr Sekhon, Cyrille P. Launay, Pierrette Gaudreau, Jose A. Morais, Gilles Allali
Summary: The combination of Motoric Cognitive Risk Syndrome (MCR) and Mild Cognitive Impairment (MCI) increases the risk of incident dementia in older adults, with MCR or MCI alone also showing an association with dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Jeremy C. S. Johnson, Charles R. Marshall, Rimona S. Weil, Doris-Eva Bamiou, Chris J. D. Hardy, Jason D. Warren
Summary: The relationship between hearing impairment and dementia highlights the crucial role of the auditory brain in cognitive function, suggesting potential opportunities for early diagnosis and management strategies. Research emphasizes the importance of auditory cognitive function in neurodegenerative dementias, calling for the development of novel auditory testing methods and early diagnosis strategies.
Article
Clinical Neurology
Jeremy C. S. Johnson, Charles R. Marshall, Rimona S. Weil, Doris-Eva Bamiou, Chris J. D. Hardy, Jason D. Warren
Summary: The association between hearing impairment and dementia poses a significant public health challenge, with potential for earlier diagnosis and prevention. Neurodegenerative pathologies are predicted to target the auditory brain and damage hearing function early. It is important to reconsider the role of auditory cognitive function in dementia and develop new auditory tests for early diagnosis.
Article
Geriatrics & Gerontology
Ji Hee Kim, In Bok Chang, Yoo Hwan Kim, Chan Yang Min, Dae Myoung Yoo, Hyo Geun Choi
Summary: This study aimed to investigate the impact of pre-existing diagnoses of Alzheimer's disease (AD) and Parkinson's disease (PD) on the susceptibility to and outcome of COVID-19. The results showed that patients with pre-existing AD had a higher risk of contracting COVID-19 and developing severe disease and mortality. On the other hand, pre-existing PD was associated with a higher risk of developing severe disease but not with mortality.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Kirsi M. Kinnunen, David M. Cash, Teresa Poole, Chris Frost, Tammie L. S. Benzinger, R. Laila Ahsan, Kelvin K. Leung, M. Jorge Cardoso, Marc Modat, Ian B. Malone, John C. Morris, Randall J. Bateman, Daniel S. Marcus, Alison Goate, Stephen P. Salloway, Stephen Correia, Reisa A. Sperling, Jasmeer P. Chhatwal, Richard P. Mayeux, Adam M. Brickman, Ralph N. Martins, Martin R. Farlow, Bernardino Ghetti, Andrew J. Saykin, Clifford R. Jack, Peter R. Schofield, Eric McDade, Michael W. Weiner, John M. Ringman, Paul M. Thompson, Colin L. Masters, Christopher C. Rowe, Martin N. Rossor, Sebastien Ourselin, Nick C. Fox
ALZHEIMERS & DEMENTIA
(2018)
Article
Clinical Neurology
Adrian Thorogood, Anna Maki-Petaja-Leinonen, Henry Brodaty, Gratien Dalpe, Chris Gastmans, Serge Gauthier, Dianne Gove, Rosie Harding, Bartha Maria Knoppers, Martin Rossor, Martin Bobrow
ALZHEIMERS & DEMENTIA
(2018)
Article
Clinical Neurology
Nicolai Franzmeier, Emrah Duezel, Frank Jessen, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Christian Haass, Marc Suarez-Calvet, Anne M. Fagan, Katrina Paumier, Tammie Benzinger, Colin L. Masters, John C. Morris, Robert Perneczky, Daniel Janowitz, Cihan Catak, Steffen Wolfsgruber, Michael Wagner, Stefan Teipel, Ingo Kilimann, Alfredo Ramirez, Martin Rossor, Mathias Jucker, Jasmeer Chhatwal, Annika Spottke, Henning Boecker, Frederic Brosseron, Peter Falkai, Klaus Fliessbach, Michael T. Heneka, Christoph Laske, Peter Nestor, Oliver Peters, Manuel Fuentes, Felix Menne, Josef Priller, Eike J. Spruth, Christiana Franke, Anja Schneider, Barbara Kofler, Christine Westerteicher, Oliver Speck, Jens Wiltfang, Claudia Bartels, Miguel Angel Araque Caballero, Coraline Metzger, Daniel Bittner, Michael Weiner, Jae-Hong Lee, Stephen Salloway, Adrian Danek, Alison Goate, Peter R. Schofield, Randall J. Bateman, Michael Ewers
Article
Clinical Neurology
Charles R. Marshall, Chris J. D. Hardy, Anna Volkmer, Lucy L. Russell, Rebecca L. Bond, Phillip D. Fletcher, Camilla N. Clark, Catherine J. Mummery, Jonathan M. Schott, Martin N. Rossor, Nick C. Fox, Sebastian J. Crutch, Jonathan D. Rohrer, Jason D. Warren
JOURNAL OF NEUROLOGY
(2018)
Article
Clinical Neurology
Miguel Angel Araque Caballero, Marc Suarez-Calvet, Marco Duering, Nicolai Franzmeier, Tammie Benzinger, Anne M. Fagan, Randall J. Bateman, Clifford R. Jack, Johannes Levin, Martin Dichgans, Mathias Jucker, Celeste Karch, Colin L. Masters, John C. Morris, Michael Weiner, Martin Rossor, Nick C. Fox, Jae-Hong Lee, Stephen Salloway, Adrian Danek, Alison Goate, Igor Yakushev, Jason Hassenstab, Peter R. Schofield, Christian Haass, Michael Ewers
Article
Biochemistry & Molecular Biology
Vivek Swarup, Flora I. Hinz, Jessica E. Rexach, Ken-ichi Noguchi, Hiroyoshi Toyoshiba, Akira Oda, Keisuke Hirai, Arjun Sarkar, Nicholas T. Seyfried, Chialin Cheng, Stephen J. Haggarty, Raffaele Ferrari, Jonathan D. Rohrer, Adaikalavan Ramasamy, John Hardy, Dena G. Hernandez, Michael A. Nalls, Andrew B. Singleton, John B. J. Kwok, Carol Dobson-Stone, William S. Brooks, Peter R. Schofield, Glenda M. Halliday, John R. Hodges, Olivier Piguet, Lauren Bartley, Elizabeth Thompson, Eric Haan, Isabel Hernandez, Agustin Ruiz, Merce Boada, Barbara Borroni, Alessandro Padovani, Nigel J. Cairns, Carlos Cruchaga, Giuliano Binetti, Roberta Ghidoni, Luisa Benussi, Gianluigi Forloni, Diego Albani, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Elio Scarpini, Jordi Clarimon, Alberto Lleo, Rafael Blesa, Maria Landqvist Waldo, Karin Nilsson, Christer Nilsson, Ian R. A. Mackenzie, Ging-Yuek R. Hsiung, David M. A. Mann, Jordan Grafman, Christopher M. Morris, Johannes Attems, Timothy D. Griffiths, Ian G. McKeith, Alan J. Thomas, Evelyn Jaros, Pietro Pietrini, Edward D. Huey, Eric M. Wassermann, Michael C. Tierney, Atik Baborie, Pau Pastor, Sara Ortega-Cubero, Cristina Razquin, Elena Alonso, Robert Perneczky, Janine Diehl-Schmid, Panagiotis Alexopoulos, Alexander Kurz, Innocenzo Rainero, Elisa Rubino, Lorenzo Pinessi, Ekaterina Rogaeva, Peter St George-Hyslop, Giacomina Rossi, Fabrizio Tagliavini, Giorgio Giaccone, James B. Rowe, Johannes C. M. Schlachetzki, James Uphill, John Collinge, Simon Mead, Adrian Danek, Vivianna M. Van Deerlin, Murray Grossman, John Q. Trojanowski, Stuart Pickering-Brown, Parastoo Momeni, Julie van der Zee, Marc Cruts, Christine Van Broeckhoven, Stefano F. Cappa, Isabelle Leber, Alexis Brice, Didier Hannequin, Veronique Golfier, Martine Vercelletto, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Irene Piaceri, Jorgen E. Nielsen, Lena E. Hjermind, Matthias Riemenschneider, Manuel Mayhaus, Gilles Gasparoni, Sabrina Pichler, Bernd Ibach, Martin N. Rossor, Nick C. Fox, Jason D. Warren, Maria Grazia Spillantini, Huw R. Morris, Patrizia Rizzu, Peter Heutink, Julie S. Snowden, Sara Rollinson, Alexander Gerhard, Anna Richardson, Amalia C. Bruni, Raffaele Maletta, Francesca Frangipane, Chiara Cupidi, Livia Bernardi, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Nicoletta Smirne, Rosa Rademakers, Matt Baker, Dennis W. Dickson, Neill R. Graff-Radford, Ronald C. Petersen, David Knopman, Keith A. Josephs, Bradley F. Boeve, Joseph E. Parisi, Bruce L. Miller, Anna M. Karydas, Howard Rosen, William W. Seeley, John C. van Swieten, Elise G. P. Dopper, Harro Seelaar, Yolande A. L. Pijnenburg, Philip Scheltens, Giancarlo Logroscino, Rosa Capozzo, Valeria Novelli, Annibale A. Puca, Massimo Franceschi, Alfredo Postiglione, Graziella Milan, Paolo Sorrentino, Mark Kristiansen, Huei-Hsin Chiang, Caroline Graff, Florence Pasquier, Adeline Rollin, Vincent Deramecourt, Thibaud Lebouvier, Luigi Ferrucci, Dimitrios Kapogiannis, Murray Grossman, Vivianna M. Van Deerlin, John Q. Trojanowski, James J. Lah, Allan I. Levey, Shinichi Kondou, Daniel H. Geschwind
Article
Biochemistry & Molecular Biology
Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Graeber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Voeglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker, Ricardo Allegri, Fatima Amtashar, Randall Bateman, Tammie Benzinger, Sarah Berman, Courtney Bodge, Susan Brandon, William Brooks, Jill Buck, Virginia Buckles, Sochenda Chea, Jasmeer Chhatwal, Patricio Chrem, Helena Chui, Jake Cinco, Jack Clifford, Carlos Cruchaga, Mirelle D'Mello, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, Anne Fagan, Marty Farlow, Angela Farrar, Howard Feldman, Gigi Flynn, Nick Fox, Erin Franklin, Hisako Fujii, Cortaiga Gant, Samantha Gardener, Bernardino Ghetti, Alison Goate, Jill Goldman, Brian Gordon, Neill Graff-Radford, Julia Gray, Jenny Gurney, Jason Hassenstab, Mie Hirohara, David Holtzman, Russ Hornbeck, Siri Houeland DiBari, Takeshi Ikeuchi, Snezana Ikonomovic, Gina Jerome, Mathias Jucker, Celeste Karch, Kensaku Kasuga, Takeshi Kawarabayashi, William Klunk, Robert Koeppe, Elke Kuder-Buletta, Christoph Laske, Jae-Hong Lee, Johannes Levin, Daniel Marcus, Ralph Martins, Neal Scott Mason, Colin Masters, Denise Maue-Dreyfus, Eric McDade, Lucy Montoya, Hiroshi Mori, John Morris, Akem Nagamatsu, Katie Neimeyer, James Noble, Joanne Norton, Richard Perrin, Marc Raichle, John Ringman, Jee Hoon Roh, Stephen Salloway, Peter Schofield, Hiroyuki Shimada, Tomoyo Shiroto, Mikio Shoji, Wendy Sigurdson, Hamid Sohrabi, Paige Sparks, Kazushi Suzuki, Laura Swisher, Kevin Taddei, Jen Wang, Peter Wang, Mike Weiner, Mary Wolfsberger, Chengjie Xiong, Xiong Xu
Article
Multidisciplinary Sciences
Alexandra L. Young, Razvan V. Marinescu, Neil P. Oxtoby, Martina Bocchetta, Keir Yong, Nicholas C. Firth, David M. Cash, David L. Thomas, Katrina M. Dick, Jorge Cardoso, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B. Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonca, Sandro Sorbi, Jason D. Warren, Sebastian Crutch, Nick C. Fox, Sebastien Ourselin, Jonathan M. Schott, Jonathan D. Rohrer, Daniel C. Alexander
NATURE COMMUNICATIONS
(2018)
Letter
Clinical Neurology
Harri Sivasathiaseelan, Charles R. Marshall, Chris J. D. Hardy, Nick C. Fox, Jason D. Warren, Martin N. Rossor
Article
Neurosciences
Claire Cury, Stanley Durrleman, David M. Cash, Marco Lorenzi, Jennifer M. Nicholas, Martina Bocchetta, John C. van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B. Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonca, Sandro Sorbi, Sebastien Ourselin, Jonathan D. Rohrer, Marc Modat, Christin Andersson, Silvana Archetti, Andrea Arighi, Luisa Benussi, Sandra Black, Maura Cosseddu, Marie Fallstrm, Carlos Ferreira, Chiara Fenoglio, Nick Fox, Morris Freedman, Giorgio Fumagalli, Stefano Gazzina, Roberta Ghidoni, Marina Grisoli, Vesna Jelic, Lize Jiskoot, Ron Keren, Gemma Lombardi, Carolina Maruta, Lieke Meeter, Rick van Minkelen, Benedetta Nacmias, Linn Ijerstedt, Alessandro Padovani, Jessica Panman, Michela Pievani, Cristina Polito, Enrico Premi, Sara Prioni, Rosa Rademakers, Veronica Redaelli, Ekaterina Rogaeva, Giacomina Rossi, Martin Rossor, Elio Scarpini, David Tang-Wai, Carmela Tartaglia, Hakan Thonberg, Pietro Tiraboschi, Ana Verdelho, Jason Warren
Article
Geriatrics & Gerontology
Jonathan Voeglein, Soheyl Noachtar, Eric McDade, Kimberly A. Quaid, Stephen Salloway, Bernardino Ghetti, James Noble, Sarah Berman, Jasmeer Chhatwal, Hiroshi Mori, Nick Fox, Ricardo Allegri, Colin L. Masters, Virginia Buckles, John M. Ringman, Martin Rossor, Peter R. Schofield, Reisa Sperling, Mathias Jucker, Christoph Laske, Katrina Paumier, John C. Morris, Randall J. Bateman, Johannes Levin, Adrian Danek
NEUROBIOLOGY OF AGING
(2019)
Editorial Material
Clinical Neurology
Martin Rossor
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Editorial Material
Pharmacology & Pharmacy
Charlotte R. Stoner, Martin Knapp, Jeroen Luyten, Claryn Kung, Marcus Richards, Raj Long, Martin Rossor
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2020)
Article
Clinical Neurology
Piers Kotting, Adam Smith, Megan B. O'Hare, Clarissa Giebel, Lakshini Mendis, Clare Shaw, Imogen Shillito, Martin N. Rossor
Summary: The development of the Join Dementia Research registry as part of the UK government's Dementia 2020 strategy has successfully increased public engagement and participation in research studies related to dementia. With over 47,000 volunteers registered, the system has enabled over 33,000 individuals to take part in various studies, resulting in a significant number of total study enrollments.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2021)
Article
Clinical Neurology
Alexander M. Rossor, Zane Jaunmuktane, Martin N. Rossor, Glen Hoti, Mary M. Reilly