Review
Biochemistry & Molecular Biology
Rossella Borghi, Valentina Magliocca, Marina Trivisano, Nicola Specchio, Marco Tartaglia, Enrico Bertini, Claudia Compagnucci
Summary: PCDH19 clustering epilepsy is a genetic disease with a heterogeneous phenotypic spectrum. The development of human brain organoids using induced pluripotent stem cell technology has provided insights into the pathomechanisms implicated in the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Lucia Del-Valle-Anton, Victor Borrell
Summary: This review discusses the molecular, cellular, histogenic, and mechanical mechanisms involved in and influencing the folding of the cerebral cortex, as well as how these mechanisms have evolved in mammals. The review also explores the pathological malformations of human cortex folding, their developmental origins, and the genetic causes behind them. Additionally, it presents the animal and in vitro models currently used to study developmental brain disorders in children and the challenges that remain in understanding brain folding.
PHYSIOLOGICAL REVIEWS
(2022)
Review
Neurosciences
Margaret M. McCarthy
Summary: Recent advancements in understanding the neurobiology of social behavior have revealed the importance of interconnected nodes in generating behavior through differential information processing. Sexual differences are fundamental in many innate social behaviors crucial for reproductive fitness. Programming of these differences is established early in development, after gonadal differentiation and androgen production. However, the connection between early-life programming of social behavior and its manifestation in adulthood remains unclear. This review proposes four core mechanisms (epigenetics, cell death, circuit formation, and adult hormonal modulation) that may link developmental changes to adult mating and aggressive behaviors, and suggests that adolescent play serves as a bridge between preweaning and postpubertal brain development by engaging similar neural networks involved in reproductive and aggressive behaviors.
ANNUAL REVIEW OF NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Zhongqing Liu, Zhaojun Wang, Zhanchi Zhu, Jing Hong, Leisha Cui, Ying Hao, Guosheng Cheng, Rui Tan
Summary: Many neurons undergo apoptosis after ischemic stroke. Crocetin (CRO), extracted from saffron, has been found to act as a neuroprotective agent for ischemic stroke. This study investigated the effect of CRO on neural stem cell (NSC) behaviors and subventricular zone neurogenesis. The results demonstrated that CRO promoted the neuronal differentiation of NSCs by activating subventricular zone neurogenesis to repair ischemic stroke.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Matthijs C. Dorst, Maria Diaz-Moreno, David O. Dias, Eduardo L. Guimaraes, Daniel Holl, Jannis Kalkitsas, Gilad Silberberg, Christian Goritz
Summary: Research has shown that inhibition of Notch signaling in astrocytes can induce adult striatal neurogenesis in the intact mouse brain. These astrocyte-derived neurons possess distinct electrophysiological properties, constituting the only glutamatergic striatal population, and have the potential to compensate for reduced neuronal activity in the striatal circuitry caused by aging or lesion-induced neuronal loss.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Michael J. Chrusch, Selena Fu, Simon C. Spanswick, Haley A. Vecchiarelli, Payal P. Patel, Matthew N. Hill, Richard H. Dyck
Summary: Zinc plays a role in modulating synaptic plasticity, particularly in the hippocampal dentate gyrus. This study aimed to determine if vesicular zinc is important for modulating adult hippocampal neurogenesis and behavior in an experience-dependent manner. The results show that vesicular zinc is essential for enhancing adult hippocampal neurogenesis and behavior following enrichment, supporting the role of zincergic neurons in experience-dependent plasticity in the hippocampus.
Article
Cell Biology
Anneline Pinson, Wieland B. Huttner
Summary: The evolutionary expansion of the neocortex is primarily due to an increased and prolonged proliferation of neural progenitor cells, with basal progenitors playing a key role in the generation of neurons. Recent studies have identified primate-specific and human-specific genes that promote increased proliferative capacity of cortical progenitors.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Augusta Gaspar, Francisco Esteves
Summary: This research aimed to investigate the development of empathy from early adolescence to adulthood and understand the nature of empathy by simultaneously assessing empathy towards humans and animals. The findings revealed that empathy towards animals and most dimensions of empathy towards humans increase with age, with higher levels of empathy observed in girls. Additionally, successful decoding of negative emotion was predicted by empathy towards humans, while skin conductance responses and subjective valence ratings predicted successful identification of positive emotion.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Yasemin B. Gultekin, David G. C. Hildebrand, Kurt Hammerschmidt, Steffen R. Hage
Summary: The vocal behavior of marmoset monkeys shows flexibility in the development of call features and sequences, correlated with stages of motor and social development, similar to humans. These findings suggest a prolonged phase of plasticity during marmoset vocal development, which is a crucial preadaptation for the emergence of vocal learning and speech in primates.
Review
Cell Biology
Vasco Sampaio-Pinto, Adrian Ruiz-Villalba, Diana S. Nascimento, Jose M. Perez-Pomares
Summary: Cardiac chamber walls contain a variety of non-contractile interstitial cells, including fibroblasts, endothelial cells, and blood lineage-derived cells. Blood cells colonize heart tissues a few days before birth, with the bone marrow playing a key role in incorporating them into the heart.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Lu Ding, Weiwei Chu, Yu Xia, Ming Shi, Tian Li, Feng-Quan Zhou, David Y. B. Deng
Summary: Activation of endogenous neural stem cells (NSCs) is limited in the spinal cord after injury due to accumulation of protein aggregates. Ubiquitin c-terminal hydrolase l-1 (UCHL1) plays a critical role in clearing protein aggregates and promoting NSC activation. Upregulation of UCHL1 enhances the proliferation of NSCs after spinal cord injury.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Elisa Floriddia
Summary: Communication between different cell types is crucial for nervous system development, and the signals that drive progenitor cells to switch from neurogenesis to astrogenesis are not fully understood. Experiments on human tissues reveal that five ligands collaborate to promote astrocyte generation and maturation.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Kathryn L. Mills, Kimberly D. Siegmund, Christian K. Tamnes, Lia Ferschmann, Lara M. Wierenga, Marieke G. N. Bos, Beatriz Luna, Chun Li, Megan M. Herting
Summary: This study examined individual variability and sex differences in changes in brain structure across ages 8.0-26.0 years. Results showed considerable inter-individual variability in brain measures, with most individuals demonstrating decreases in certain areas during mid-adolescence. There were also sex differences in these patterns and an association between brain structure size and rate of change.
Article
Neurosciences
Shawn F. Sorrells, Mercedes F. Paredes, Zhuangzhi Zhang, Gugene Kang, Oier Pastor-Alonso, Sean Biagiotti, Chloe E. Page, Kadellyn Sandoval, Anthony Knox, Andrew Connolly, Eric J. Huang, Jose Manuel Garcia-Verdugo, Michael C. Oldham, Zhengang Yang, Arturo Alvarez-Buylla
Summary: Adult hippocampal neurogenesis was initially discovered in rodents, with subsequent studies identifying adult neural stem cells and their links to plasticity, behavior, and disease. The debate continues as to whether new neurons are produced in the human dentate gyrus during healthy aging. Recent research has shown conflicting results regarding the presence of dividing neuronal precursors in the adult human brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Anna M. Dischler, Drew Maslar, Chen Zhang, Yan Qin
Summary: A genetically encoded, single red fluorescent protein-based Zn2+ sensor, RZnP1, has been developed, which can detect intracellular concentrations of Zn2+ with sensitivity, brightness, and specificity. By combining with other sensors, simultaneous recording of different ions in cells is possible.
Article
Biochemistry & Molecular Biology
Rohit Seth, Rikki S. Corniola, Shannon D. Gower-Winter, Thomas J. Morgan, Brian Bishop, Cathy W. Leyenson
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2015)
Article
Neurosciences
Elise C. Cope, Deborah R. Morris, Shannon D. Gower-Winter, Naomi C. Brownstein, Cathy W. Levenson
EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
Ali Darkazalli, Abdol Aziz Ould Ismail, Nastaren Abad, Samuel C. Grant, Cathy W. Levenson
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2016)
Article
Critical Care Medicine
Ali Darkazalli, Cynthia Vied, Crystal-Dawn Badger, Cathy W. Levenson
JOURNAL OF NEUROTRAUMA
(2017)
Article
Biochemical Research Methods
Kate J. F. Carnevale, Megan E. Muroski, Parth N. Vakil, Megan E. Foley, Geoffry Laufersky, Rachael Kenworthy, Diego A. R. Zorio, Thomas J. Morgan, Cathy W. Levenson, Geoffrey F. Strouse
BIOCONJUGATE CHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Shannon D. Gower-Winter, Cathy W. Levenson
Review
Endocrinology & Metabolism
Deborah R. Morris, Cathy W. Levenson
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2013)
Article
Chemistry, Inorganic & Nuclear
J. Tyler Simmons, John R. Allen, Deborah R. Morris, Ronald J. Clark, Cathy W. Levenson, Michael W. Davidson, Lei Zhu
INORGANIC CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Deborah R. Morris, Cathy W. Levenson
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2013)
Article
Chemistry, Multidisciplinary
Megan E. Muroski, Thomas J. Morgan, Cathy W. Levenson, Geoffrey F. Strouse
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Review
Nutrition & Dietetics
Elise C. Cope, Deborah R. Morris, Cathy W. Levenson
Article
Neurosciences
Shannon D. Gower-Winter, Rikki S. Corniola, Thomas J. Morgan, Cathy W. Levenson
NUTRITIONAL NEUROSCIENCE
(2013)
Article
Biochemical Research Methods
Prabu Sellappan, Jason Cote, Phillip A. Kreth, Victor D. Schepkin, Ali Darkazalli, Deborah R. Morris, Farrukh S. Alvi, Cathy W. Levenson
JOURNAL OF NEUROSCIENCE METHODS
(2019)
Article
Nutrition & Dietetics
Katrina A. Hall, Maria T. Spicer, Jasminka Z. Ilich, Cathy W. Levenson
TOPICS IN CLINICAL NUTRITION
(2019)
Review
Toxicology
Deborah R. Morris, Cathy W. Levenson
JOURNAL OF TOXICOLOGY
(2012)
Review
Nutrition & Dietetics
Chong-Su Kim
Summary: The gut microbiota plays a crucial role in brain function through the gut-brain axis. This review highlights the effects of gut microbiota-derived dietary metabolites on cell-to-cell interactions in the central nervous system, particularly microglia, astrocytes, and neuronal cells, affecting cognitive function, mood, and behavior. The review also discusses the potential of diet-induced microbial metabolite-based therapies as novel approaches to mental health treatment.
ADVANCES IN NUTRITION
(2024)
