Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay
出版年份 2018 全文链接
标题
Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay
作者
关键词
-
出版物
Scientific Reports
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-01-03
DOI
10.1038/s41598-017-18650-x
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor
- (2017) Marco P Licciardello et al. Nature Chemical Biology
- Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells
- (2016) R. Ferraldeschi et al. CANCER RESEARCH
- Quantitating drug-target engagement in single cells in vitro and in vivo
- (2016) J Matthew Dubach et al. Nature Chemical Biology
- Screening out irrelevant cell-based models of disease
- (2016) Peter Horvath et al. NATURE REVIEWS DRUG DISCOVERY
- A scalable strategy for high-throughput GFP tagging of endogenous human proteins
- (2016) Manuel D. Leonetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
- (2016) Yundong He et al. Nature Communications
- CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
- (2016) Helena Almqvist et al. Nature Communications
- Cross-talk between androgen receptor/filamin A and TrkA regulates neurite outgrowth in PC12 cells
- (2015) Marzia Di Donato et al. MOLECULAR BIOLOGY OF THE CELL
- Targeting the MLL complex in castration-resistant prostate cancer
- (2015) Rohit Malik et al. NATURE MEDICINE
- Target engagement and drug residence time can be observed in living cells with BRET
- (2015) Matthew B. Robers et al. Nature Communications
- ASC-J9 Suppresses Castration-Resistant Prostate Cancer Growth through Degradation of Full-length and Splice Variant Androgen Receptors
- (2015) Shinichi Yamashita et al. NEOPLASIA
- Androgen receptor: structure, role in prostate cancer and drug discovery
- (2014) MH Eileen Tan et al. ACTA PHARMACOLOGICA SINICA
- Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer
- (2014) MarkN Stein et al. ASIAN JOURNAL OF ANDROLOGY
- Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles
- (2014) Elaine Kirschke et al. CELL
- Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer
- (2014) C. Liu et al. CLINICAL CANCER RESEARCH
- Selectively Targeting the DNA-binding Domain of the Androgen Receptor as a Prospective Therapy for Prostate Cancer
- (2014) Kush Dalal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
- (2014) Irfan A. Asangani et al. NATURE
- The cellular thermal shift assay for evaluating drug target interactions in cells
- (2014) Rozbeh Jafari et al. Nature Protocols
- Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity
- (2014) Changmeng Cai et al. Cell Reports
- Determining target engagement in living systems
- (2013) Gabriel M Simon et al. Nature Chemical Biology
- The transience of transient overexpression
- (2013) Toby J Gibson et al. NATURE METHODS
- Appraising iniparib, the PARP inhibitor that never was—what must we learn?
- (2013) Joaquin Mateo et al. Nature Reviews Clinical Oncology
- TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer
- (2013) M. D. Nyquist et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
- (2013) D. M. Molina et al. SCIENCE
- ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
- (2012) N. J. Clegg et al. CANCER RESEARCH
- Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines
- (2012) Y. Li et al. CANCER RESEARCH
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
- (2012) Sarah K Knutson et al. Nature Chemical Biology
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex
- (2012) Zhijian Duan et al. PROSTATE
- EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
- (2012) K. Xu et al. SCIENCE
- Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
- (2012) Sharad K. Verma et al. ACS Medicinal Chemistry Letters
- Primary Cells and Stem Cells in Drug Discovery: Emerging Tools for High-Throughput Screening
- (2010) Richard Eglen et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Trk kinase inhibitors as new treatments for cancer and pain
- (2009) Tao Wang et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit
- (2009) Michael L. Mohler et al. JOURNAL OF MEDICINAL CHEMISTRY
- Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target
- (2009) Yu Chen et al. LANCET ONCOLOGY
- Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
- (2009) C. Tran et al. SCIENCE
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