标题
Determining target engagement in living systems
作者
关键词
-
出版物
Nature Chemical Biology
Volume 9, Issue 4, Pages 200-205
出版商
Springer Nature
发表日期
2013-03-19
DOI
10.1038/nchembio.1211
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
- (2013) Meghna Das Thakur et al. NATURE
- Activity-Based Probes for Studying the Activity of Flavin-Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors
- (2012) Joanna M. Krysiak et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Clinical perspectives for irreversible tyrosine kinase inhibitors in cancer
- (2012) Caterina Carmi et al. BIOCHEMICAL PHARMACOLOGY
- Interrogating Signaling Nodes Involved in Cellular Transformations Using Kinase Activity Probes
- (2012) Cliff I. Stains et al. CHEMISTRY & BIOLOGY
- A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages
- (2012) Martijn Verdoes et al. CHEMISTRY & BIOLOGY
- Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies
- (2012) Ranjana H. Advani et al. JOURNAL OF CLINICAL ONCOLOGY
- Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes
- (2012) Alexander Adibekian et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe
- (2012) Laura E. Edgington et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Drug candidates derailed in case of mistaken identity
- (2012) Heidi Ledford NATURE
- Using transcriptome sequencing to identify mechanisms of drug action and resistance
- (2012) Sarah A Wacker et al. Nature Chemical Biology
- DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses
- (2012) Ku-Lung Hsu et al. Nature Chemical Biology
- The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
- (2012) Marc B. Skaddan et al. NUCLEAR MEDICINE AND BIOLOGY
- Brain Penetrant LRRK2 Inhibitor
- (2012) Hwan Geun Choi et al. ACS Medicinal Chemistry Letters
- Positron emission tomography molecular imaging for drug development
- (2011) Paul M. Matthews et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases
- (2011) Matthew P. Patricelli et al. CHEMISTRY & BIOLOGY
- Lipidomics at the Interface of Structure and Function in Systems Biology
- (2011) Richard W. Gross et al. CHEMISTRY & BIOLOGY
- Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
- (2011) S. Arastu-Kapur et al. CLINICAL CANCER RESEARCH
- Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes
- (2011) Laura E Edgington et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
- (2011) Marcus Bantscheff et al. NATURE BIOTECHNOLOGY
- Identification of Direct Target Engagement Biomarkers for Kinase-Targeted Therapeutics
- (2011) Cloud P. Paweletz et al. PLoS One
- Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
- (2011) D. A. Bachovchin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma
- (2011) N. Suwaki et al. Science Translational Medicine
- Evaluation of 11C-GSK189254 as a Novel Radioligand for the H3 Receptor in Humans Using PET
- (2010) S. Ashworth et al. JOURNAL OF NUCLEAR MEDICINE
- Chemical phylogenetics of histone deacetylases
- (2010) James E Bradner et al. Nature Chemical Biology
- The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
- (2010) L. A. Honigberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small-animal positron emission tomography as a tool for neuropharmacology
- (2010) Sophie Lancelot et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
- (2009) Kay Ahn et al. CHEMISTRY & BIOLOGY
- Sensitive multiplexed analysis of kinase activities and activity-based kinase identification
- (2009) Kazuishi Kubota et al. NATURE BIOTECHNOLOGY
- Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes
- (2009) Laura E Edgington et al. NATURE MEDICINE
- Target site occupancy: Emerging generalizations from clinical and preclinical studies
- (2009) Sarah Grimwood et al. PHARMACOLOGY & THERAPEUTICS
- Accelerating Drug Development Using Biomarkers: A Case Study with Sitagliptin, A Novel DPP4 Inhibitor for Type 2 Diabetes
- (2008) Rajesh Krishna et al. AAPS Journal
- Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
- (2008) Benjamin F. Cravatt et al. Annual Review of Biochemistry
- Peptidase substrates via global peptide profiling
- (2008) Debarati M Tagore et al. Nature Chemical Biology
- Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
- (2008) Beth Apsel et al. Nature Chemical Biology
- Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
- (2008) Jonathan Z Long et al. Nature Chemical Biology
- The Role of Imaging in Proof of Concept for CNS Drug Discovery and Development
- (2008) Dean F Wong et al. NEUROPSYCHOPHARMACOLOGY
- Strategic Approach to Fit-for-Purpose Biomarkers in Drug Development
- (2007) John A. Wagner Annual Review of Pharmacology and Toxicology
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now