Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling

(2016) Christoph H. Emmerich et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

(2015) Geoffrey O. Gillard et al.   JOURNAL OF NEUROIMMUNOLOGY

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

(2015) Melanie S. Brennan et al.   PLoS One

Mode of action and clinical studies with fumarates in multiple sclerosis

(2014) Anke Salmen et al.   EXPERIMENTAL NEUROLOGY

The TLR and IL-1 signalling network at a glance

(2014) P. Cohen   JOURNAL OF CELL SCIENCE

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

(2014) Marta Lopez-Pelaez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Janus kinase inhibitors in autoimmune diseases

(2013) John J O'Shea et al.   ANNALS OF THE RHEUMATIC DISEASES

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

(2013) Sam Strickson et al.   BIOCHEMICAL JOURNAL

Second generation S1P pathway modulators: Research strategies and clinical developments

(2013) Marc Bigaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition

(2013) Matthias Gaestel   BIOLOGICAL CHEMISTRY

The ubiquitin conjugating enzyme UBE2L3 regulates TNFα-induced linear ubiquitination

(2013) Bishi Fu et al.   CELL RESEARCH

Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy

(2013) Alexander J. Gill et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

(2013) Navasona Krishnan et al.   FEBS Journal

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling

(2013) Laith M. A. Al-Huseini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice

(2013) E. Pauls et al.   JOURNAL OF IMMUNOLOGY

Cross Talk between the Akt and p38  Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

(2013) V. A. McGuire et al.   MOLECULAR AND CELLULAR BIOLOGY

MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop

(2013) K. F. MacKenzie et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular control of the NEMO family of ubiquitin-binding proteins

(2013) Kristopher Clark et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Back to the future: oral targeted therapy for RA and other autoimmune diseases

(2013) John J. O'Shea et al.   Nature Reviews Rheumatology

Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

(2013) Suzanne E. Elcombe et al.   PLoS One

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear ubiquitination: a newly discovered regulator of cell signalling

(2013) Eva Rieser et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dimethylfumarate inhibits CXCL10 via haem oxygenase-1 in airway smooth muscle

(2012) P. Seidel et al.   EUROPEAN RESPIRATORY JOURNAL

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral BG12 for treatment of relapsing–remitting MS

(2012) Volker Limmroth   Nature Reviews Neurology

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression

(2011) B. Gesser et al.   INFLAMMATION RESEARCH

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

(2011) Marissa L. Matsumoto et al.   JOURNAL OF MOLECULAR BIOLOGY

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

State-of-the-art: rheumatoid arthritis

(2010) I. B. McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Dimethylfumarate inhibits NF-κB function at multiple levels to limit airway smooth muscle cell cytokine secretion

(2009) P. Seidel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fumaric Acid and its Esters: An Emerging Treatment for Multiple Sclerosis

(2009) D. Moharregh-Khiabani et al.   Current Neuropharmacology

REDOX Reaction at ASK1-Cys250 Is Essential for Activation of JNK and Induction of Apoptosis

(2009) Philippe J. Nadeau et al.   MOLECULAR BIOLOGY OF THE CELL

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of I B  Kinase

(2008) M. Windheim et al.   MOLECULAR AND CELLULAR BIOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY