Article
Microbiology
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Muller, Robert C. Glen, David Vauzour, Simon McArthur
Summary: The study shows that methylamine substances can directly affect the integrity of the blood-brain barrier in mammals by improving its function through regulation of tight junction proteins. Long-term exposure to trimethylamine N-oxide helps protect cognitive function, reducing astrocyte and microglial reactivity in specific brain regions.
Article
Nutrition & Dietetics
Manman Lu, Yuhui Yang, Yuncong Xu, Xiaoyue Wang, Bo Li, Guowei Le, Yanli Xie
Summary: Dietary methionine restriction (MR) can reduce plasma trimethylamine-N-oxide (TMAO) levels by manipulating gut microbiota in mice. MR decreases the ability of gut microbiota to produce trimethylamine (TMA), reduces TMA levels and expression of choline TMA-lyase (CutC) in the intestine, and increases the abundance of SCFA-producing bacteria.
Article
Immunology
Lingling Xiao, Lingyan Huang, Xin Zhou, Dan Zhao, Yan Wang, Haiyan Min, Shiyu Song, Weibin Sun, Qian Gao, Qingang Hu, Sijing Xie
Summary: Our study found that experimental periodontitis in ApoE(-/-) mice led to gut dysbiosis and an increase in TMAO. These results suggest a possible mechanism by which periodontitis may accelerate atherosclerosis by influencing the intestinal microbes and metabolism, triggered by inflammation of the liver and intestine.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Qianqian Wang, Min Guo, Yang Liu, Mengshu Xu, Liuting Shi, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study found that certain strains of Bifidobacterium can reduce the production of plasma TMAO and modulate the gut microbiota. These strains may have therapeutic potential for preventing TMAO-related diseases such as atherosclerosis.
Review
Clinical Neurology
Yuan Liu, Juan Qu, Junjie Xu, Aiming Gu, Dezhi Deng, Xiaodan Jia, Baoxiang Wang
Summary: Ischemic stroke is a common and burdensome cerebrovascular disease. Trimethylamine-N-oxide (TMAO), a metabolite produced by intestinal microorganisms, has been associated with stroke risk, severity, and prognosis, although this remains controversial. This article reviews TMAO production, its relationship with different etiological types of ischemic stroke, and the potential for reducing TMAO levels to improve stroke prognosis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Agriculture, Multidisciplinary
Hana Lee, Xin Liu, Jin-Pyo An, Yu Wang
Summary: This study investigates the inhibitory effects of polymethoxyflavones (PMFs) on enzymes involved in the production of trimethylamine (TMA) and trimethylamine-N-oxide (TMAO). The findings suggest that specific structural features of PMFs contribute to their interactions with enzymes. Furthermore, the study introduces a novel model system to assess and compare the inhibitory effects of PMFs on TMAO production. These findings could potentially lead to the development of novel therapeutic approaches to manage cardiovascular disease (CVD).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Olga M. Zarechnaya, Aleksei A. Anisimov, Eugenii Yu Belov, Nikolai Burakov, Alexander L. Kanibolotsky, Vasilii A. Mikhailov
Summary: At ambient conditions, halogens readily interact with trimethylamine-N-oxide to form stable 1 : 1 adducts, with the OMIDLINE HORIZONTAL ELLIPSISX-Y halogen bond being the main factor for the thermodynamic stability of these complexes.
Review
Cardiac & Cardiovascular Systems
Lele Jing, Honghong Zhang, Qiannan Xiang, Liang Shen, Xiaoxia Guo, Changlin Zhai, Huilin Hu
Summary: This article summarizes the important progress in the evaluation of TMAO and AS in recent years and highlights novel potential approaches for the prevention and treatment of AS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qi-Long Qin, Zhi-Bin Wang, Hai-Nan Su, Xiu-Lan Chen, Jie Miao, Xiu-Juan Wang, Chun-Yang Li, Xi-Ying Zhang, Ping-Yi Li, Min Wang, Jiasong Fang, Ian Lidbury, Weipeng Zhang, Xiao-Hua Zhang, Gui-Peng Yang, Yin Chen, Yu-Zhong Zhang
Summary: Researchers have found that a piezotolerant bacterium has a two-step metabolic pathway to adapt to high hydrostatic pressure by utilizing trimethylamine, which improves growth and survival rates under such conditions.
Article
Biochemistry & Molecular Biology
Adhini Kuppuswamy Satheesh Babu, Chrissa Petersen, Lisard Iglesias-Carres, Henry A. Paz, Umesh D. Wankhade, Andrew P. Neilson, Pon Velayutham Anandh Babu
Summary: This study investigated the effects of dietary blueberries and strawberries on the production of TMAO, a metabolite associated with various diseases. The results showed that blueberry supplementation reduced circulating TMAO levels, while strawberry supplementation did not have this effect. Antibiotics drastically reduced TMA and TMAO levels. Blueberry supplementation also increased the abundance of bacteria that are negatively associated with TMAO.
Article
Clinical Neurology
Jie Xu, Aichun Cheng, Bo Song, Mingming Zhao, Jing Xue, Anxin Wang, Liye Dai, Jing Jing, Xia Meng, Hao Li, Lemin Zheng, Yongjun Wang
Summary: Elevated TMAO levels are associated with an increased risk of stroke recurrence, particularly in patients with small artery occlusion subtype.
Article
Biochemistry & Molecular Biology
Yuhang Huang, Fanjie Lin, Ruidi Tang, Changlei Bao, Qingxun Zhou, Kaiwen Ye, Yi Shen, Chunli Liu, Cheng Hong, Kai Yang, Haiyang Tang, Jian Wang, Wenju Lu, Tao Wang
Summary: The study demonstrates that elevated levels of TMAO are associated with severe PH, and reducing TMAO can decrease pulmonary vascular muscularization and alleviate PH. Additionally, TMAO can promote the production of chemokines and cytokines by suppressing macrophages.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Review
Biochemical Research Methods
Ruey Leng Loo, Queenie Chan, Jeremy K. Nicholson, Elaine Holmes
Summary: Trimethylamine (TMA) and its N-oxide (TMAO) play important roles in evolutionary biology and diverse biochemical functions, including cell signaling. The significance of TMA and TMAO extends beyond cardiovascular disease risk, encompassing multiple biological processes.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Chemistry, Analytical
Wen Zhang, Jiao Sun, Fang Wang, Jiang Liu, Ying Han, Miao Jiang, Dongqi Tang
Summary: Researchers have developed a new method for fluorescent enzymatic analysis of TMAO, which has high sensitivity and accuracy, showing great potential for clinical diagnosis applications.
ANALYTICAL METHODS
(2021)
Article
Neurosciences
Sankar Simla Praveenraj, Sharma Sonali, Nikhilesh Anand, Hediyal Ahmed Tousif, Chandrasekaran Vichitra, Manjunath Kalyan, Perumalswamy Velumani Kanna, Kumar A. Chandana, Paneyala Shasthara, Arehally M. Mahalakshmi, Jian Yang, Seithikurippu R. Pandi-Perumal, Meena Kishore Sakharkar, Saravana Babu Chidambaram
Summary: Trimethylamine lyases are enzymes expressed in intestinal microbiota that metabolize dietary nutrients to produce trimethylamine (TMA). Trimethylamine N-oxide (TMAO) is a product of TMA metabolism and has been shown to contribute to the development of metabolic, cardiovascular, and cerebrovascular diseases. This manuscript summarizes the harmful effects of TMAO on neurodegenerative and sleep disorders, as well as its predictive role in neurological disorders. Mechanisms such as activation of inflammatory signaling pathways and mitochondrial dysfunction are involved in TMAO-mediated pathogenesis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Avinash Mishra, Shoba Ranganathan, B. Jayaram, Abdul Sattar
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Kamalika Banerjee, Ruchika Bhat, V. U. Bhaskara Rao, Anshu Nain, Kartik Lakshmi Rallapalli, Sohona Gangopadhyay, R. P. Singh, Manidipa Banerjee, Bhyravabhotla Jayaram
Article
Biochemistry & Molecular Biology
Bhaskar K. Chatterjee, Abhilash Jayaraj, Vinay Kumar, Brian Blagg, Rachel E. Davis, B. Jayaram, Shashank Deep, Tapan K. Chaudhuri
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Pradeep Pant, Amita Pathak, B. Jayaram
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2020)
Article
Biochemistry & Molecular Biology
Pradeep Pant, B. Jayaram
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biology
Ali Khosravi, Morteza Kouhsar, Bahram Goliaei, B. Jayaram, Ali Masoudi-Nejad
COMPUTERS IN BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Ali Khosravi, B. Jayaram, Bahram Goliaei, Ali Masoudi-Nejad
MOLECULAR MEDICINE
(2019)
Article
Biochemical Research Methods
Akhilesh Mishra, Sahil Dhanda, Priyanka Siwach, Shruti Aggarwal, B. Jayaram
Article
Biochemistry & Molecular Biology
Anjali Soni, Ruchika Bhat, B. Jayaram
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
(2020)
Article
Engineering, Chemical
Ruchika Bhat, Rahul Kaushik, Ankita Singh, Debarati DasGupta, Abhilash Jayaraj, Anjali Soni, Ashutosh Shandilya, Vandana Shekhar, Shashank Shekhar, B. Jayaram
CHEMICAL ENGINEERING SCIENCE
(2020)
Article
Virology
Praveen Kumar Tripathi, Anjali Soni, Shiv Pratap Singh Yadav, Ankit Kumar, Nitika Gaurav, Siva Raghavendhar, Pradeep Sharma, Sujatha Sunil, Ashish, Bhyravabhotla Jayaram, Ashok Kumar Patel
Article
Multidisciplinary Sciences
Fereshteh Mataeimoghadam, M. A. Hakim Newton, Abdollah Dehzangi, Abdul Karim, B. Jayaram, Shoba Ranganathan, Abdul Sattar
SCIENTIFIC REPORTS
(2020)
Article
Mathematical & Computational Biology
Ankita Singh, Rahul Kaushik, Dheeraj Kumar Chaurasia, Manpreet Singh, B. Jayaram
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2020)
Article
Chemistry, Organic
Venkatesan Santhanam, Pradeep Pant, B. Jayaram, Namakkal G. Ramesh
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Rahul Kaushik, Ankita Singh, B. Jayaram