The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders

The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke

(2022) Saravana Babu Chidambaram et al.   Cells

Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far?

(2021) Karen Salve Coutinho-Wolino et al.   EUROPEAN JOURNAL OF NUTRITION

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway

(2021) Weifei Zhu et al.   Cell Host & Microbe

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

(2021) Saravana Babu Chidambaram et al.   PHARMACOLOGY & THERAPEUTICS

Gut microbiota alterations in response to sleep length among African-origin adults

(2021) Na Fei et al.   PLoS One

The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis

(2021) Zeneng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relationship between sleep disorders and gut dysbiosis: what affects what?

(2021) Bruna Neroni et al.   SLEEP MEDICINE

Dietary patterns affect Parkinson's disease via the microbiota-gut-brain axis

(2021) Chuan-Qi Chu et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Relationship between elevated plasma trimethylamine N-oxide levels and increased stroke injury

(2020) Chuanjie Wu et al.   NEUROLOGY

Trimethylamine N-Oxide in Relation to Cardiometabolic Health—Cause or Effect?

(2020) Christopher Papandreou et al.   Nutrients

Treatments of trimethylaminuria: where we are and where we might be heading

(2020) Aaron C. Schmidt et al.   DRUG DISCOVERY TODAY

Gut microbiota-associated metabolite trimethylamine N-Oxide and the risk of stroke: a systematic review and dose–response meta-analysis

(2020) Mahdieh Abbasalizad Farhangi et al.   Nutrition Journal

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

(2020) Manoj Govindarajulu et al.   Frontiers in Molecular Neuroscience

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

(2020) Moira Marizzoni et al.   JOURNAL OF ALZHEIMERS DISEASE

The Gut Metabolite Trimethylamine N‐Oxide Is Associated With Parkinson's Disease Severity and Progression

(2020) Szu‐Ju Chen et al.   MOVEMENT DISORDERS

Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis

(2020) Lu Chen et al.   Scientific Reports

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

(2020) Vienna E. Brunt et al.   GeroScience

The gut microbiome as a target for adjuvant therapy in obstructive sleep apnea

(2020) Mohammad Badran et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Gut microbiota-derived metabolite trimethylamine N-oxide as a biomarker in early Parkinson's disease

(2020) Seok Jong Chung et al.   NUTRITION

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

Lactobacillus rhamnosus GG strain mitigated the development of obstructive sleep apnea-induced hypertension in a high salt diet via regulating TMAO level and CD4+ T cell induced-type I inflammation

(2019) Jing Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Serum levels of Trimethylamine-N-oxide in patients with ischemic stroke

(2019) Maimaiti Rexidamu et al.   BIOSCIENCE REPORTS

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

Dendritic spines: Revisiting the physiological role

(2019) Saravana Babu Chidambaram et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

(2019) Jiayi Zhao et al.   Scientific Reports

The Presence of High Levels of Circulating Trimethylamine N-Oxide Exacerbates Central and Peripheral Inflammation and Inflammatory Hyperalgesia in Rats Following Carrageenan Injection

(2019) Yanan Zhang et al.   INFLAMMATION

Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease

(2019) Qiang Gao et al.   Aging-US

Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson’s disease

(2019) Bartłomiej Sankowski et al.   CLINICA CHIMICA ACTA

Obstructive Sleep Apnea and Systemic Hypertension: Gut Dysbiosis as the Mediator?

(2019) Saif Mashaqi et al.   Journal of Clinical Sleep Medicine

Gut microbiome diversity is associated with sleep physiology in humans

(2019) Robert P. Smith et al.   PLoS One

Astrocyte senescence contributes to cognitive decline

(2019) Tamas Csipo et al.   GeroScience

Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels

(2019) Aven Lee et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Trimethylamine-N-oxide, as a risk factor for atherosclerosis, induces stress in J774A.1 murine macrophages

(2018) Abbas Mohammadi et al.   Advances in Medical Sciences

Trimethylamine-N -oxide promotes brain aging and cognitive impairment in mice

(2018) Dang Li et al.   AGING CELL

Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

(2018) Arash Haghikia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway

(2018) Jin Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Elevated trimethylamineN-oxide related to ischemic brain lesions after carotid artery stenting

(2018) Chuanjie Wu et al.   NEUROLOGY

Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson’s Disease Model in Mice

(2018) Sugumar Mani et al.   NEUROTOXICITY RESEARCH

Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism

(2018) Sathiya Sekar et al.   NEUROTOXICITY RESEARCH

Lower plasma choline levels are associated with sleepiness symptoms

(2018) Victoria M. Pak et al.   SLEEP MEDICINE

Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease

(2018) Geraldine Kong et al.   NEUROBIOLOGY OF DISEASE

Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients

(2018) Jing Nie et al.   STROKE

Rebuilding the Gut Microbiota Ecosystem

(2018) Antonella Gagliardi et al.   International Journal of Environmental Research and Public Health

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

(2018) Siamak MahmoudianDehkordi et al.   Alzheimers & Dementia

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

(2018) Manuel Janeiro et al.   Nutrients

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

(2018) Nicholas M. Vogt et al.   Alzheimers Research & Therapy

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

(2017) Xinmin S. Li et al.   EUROPEAN HEART JOURNAL

The metabolic fate of isotopically labeled trimethylamine- N -oxide (TMAO) in humans

(2017) Siraphat Taesuwan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease

(2017) James A.P. Tomlinson et al.   KIDNEY INTERNATIONAL

Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature

(2017) Susanne A. Schneider et al.   MOVEMENT DISORDERS

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

(2017) Daniele Del Rio et al.   Nutrients

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

(2017) Marc-Emmanuel Dumas et al.   Cell Reports

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

(2017) Tiejun Li et al.   Frontiers in Physiology

Normoalbuminuric diabetic kidney disease

(2017) Chao Chen et al.   Frontiers of Medicine

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

(2016) Rong Xu et al.   BMC Systems Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

A gut (microbiome) feeling about the brain

(2016) Eoin Sherwin et al.   CURRENT OPINION IN GASTROENTEROLOGY

The complex metabolism of trimethylamine in humans: endogenous and exogenous sources

(2016) Jyoti Chhibber-Goel et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial

(2016) Clara E. Cho et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models

(2016) C. Pellegrini et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

(2016) Valeria D. Felice et al.   PARKINSONISM & RELATED DISORDERS

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Trimethylamine N-Oxide: The Good, the Bad and the Unknown

(2016) Manuel Velasquez et al.   Toxins

Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing

(2016) Xin Fang et al.   Frontiers in Microbiology

Traditional Risk Factors for Stroke in East Asia

(2016) Young Dae Kim et al.   Journal of Stroke

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

A Chemical Chaperone-Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

(2015) Tamar Getter et al.   ChemMedChem

The impact of gut microbiota on brain and behaviour

(2015) Timothy G. Dinan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Advances in the immunopathogenesis of multiple sclerosis

(2015) Sudhir K. Yadav et al.   CURRENT OPINION IN NEUROLOGY

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

(2015) David J. Durgan et al.   HYPERTENSION

Trimethylamine-N-Oxide Treatment Induces Changes in the ATP-Binding Cassette Transporter A1 and Scavenger Receptor A1 in Murine Macrophage J774A.1 cells

(2015) Abbas Mohammadi et al.   INFLAMMATION

Plasma Concentrations of Trimethylamine-N-oxide Are Directly Associated with Dairy Food Consumption and Low-Grade Inflammation in a German Adult Population

(2015) Sabine Rohrmann et al.   JOURNAL OF NUTRITION

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Short-term high-fat diet increases postprandial trimethylamine- N -oxide in humans

(2015) Nabil E. Boutagy et al.   NUTRITION RESEARCH

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation

(2015) Guro F. Giskeødegård et al.   Scientific Reports

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO

(2014) Robert A. Koeth et al.   Cell Metabolism

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea

(2014) Isabel Moreno-Indias et al.   EUROPEAN RESPIRATORY JOURNAL

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

(2014) J. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

(2014) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Genetic variation in Clusterin gene and Alzheimer's disease risk in Han Chinese

(2013) Jin-Tai Yu et al.   NEUROBIOLOGY OF AGING

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease

(2013) Kareem Rashid Rumah et al.   PLoS One

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

(2013) E. Cristante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS

(2013) Ettore Beghi et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine

(2012) Hisashi Muramatsu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

(2012) S. Craciun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Programming of Host Metabolism by the Gut Microbiota

(2011) Fredrik Bäckhed   ANNALS OF NUTRITION AND METABOLISM

Natural Osmolytes Remodel the Aggregation Pathway of Mutant Huntingtin Exon 1

(2011) Tejas Borwankar et al.   BIOCHEMISTRY

1H NMR based metabolomics of CSF and blood serum: A metabolic profile for a transgenic rat model of Huntington disease

(2011) Kim A. Verwaest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives

(2011) M. Joossens et al.   GUT

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice

(2011) Jorien M.M. van der Burg et al.   NEUROBIOLOGY OF DISEASE

Brain?Gut?Microbe Communication in Health and Disease

(2011) Sue Grenham et al.   Frontiers in Physiology

Replication of CLU, CR1, and PICALM Associations With Alzheimer Disease

(2010) Minerva M. Carrasquillo et al.   ARCHIVES OF NEUROLOGY

Amyotrophic Lateral Sclerosis

(2010) Paul H. Gordon   CNS DRUGS

Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergetics

(2010) Chidambaram Saravana Babu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

A Pathologic Cascade Leading to Synaptic Dysfunction in  -Synuclein-Induced Neurodegeneration

(2010) D. A. Scott et al.   JOURNAL OF NEUROSCIENCE

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Upper gastrointestinal findings in Huntington’s disease: patients suffer but do not complain

(2009) Jürgen E. Andrich et al.   JOURNAL OF NEURAL TRANSMISSION

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats

(2009) C. Saravana Babu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE