Article
Cell Biology
Dongliang Liu, Xiaofang Zeng, Le Li, Zheng-Lin Ou
Summary: The study demonstrates that L-carnitine can improve oxidative stress recovery and prolong lifespan in C. elegans, with its uptake being associated with a new gene T08B1.1, which may play an important role in healthy aging.
Article
Veterinary Sciences
Mohsen Danesh Mesgaran, Hassan Kargar, Rieke Janssen, Sadjad Danesh Mesgaran, Aghil Ghesmati, Amirmansour Vatankhah
Summary: This study investigated the impact of a rumen-protected zinc-methionine complex on high-producing dairy cows during a heat stress period. The results showed that supplementing with the zinc-methionine complex maintained milk production and composition, improved oxidative and immune status.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Mladenovic Djordjevic, Natasa Loncarevic-Vasiljkovic, Efstathios S. Gonos
Summary: It is well established that lifestyle and dietary habits have a significant impact on life span, aging rate, and age-related diseases. Dietary restriction and healthy dietary patterns have been linked to increased survival and longevity, with the ability to modify oxidative stress levels. However, the debate regarding the role of dietary restriction as a golden standard for prolonging life span and ameliorating aging effects continues.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Immunology
Wei Zhang, Lu Xiang, Peng Luo, Dili Xie
Summary: Cardiovascular aging is a significant factor contributing to cardiovascular disease, and alpha-lactalbumin has been found to have anti-aging potential in attenuating cardiovascular aging, inflammation, and oxidative stress. Both in vitro and in vivo experiments support this finding, suggesting that alpha-lactalbumin could be a promising anti-aging functional food in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Maria B. Birkisdottir, Dick Jaarsma, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Sandra Imholz, Conny T. van Oostrom, Bhawani Nagarajah, Eliana Portilla Fernandez, Anton J. M. Roks, Ype Elgersma, Harry van Steeg, Jose A. Ferreira, Jeroen L. A. Pennings, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Martijn E. T. Dolle
Summary: Experimental results show that although dietary restriction and rapamycin can extend the lifespan of some organisms, rapamycin cannot increase the lifespan and healthspan of progeroid DNA repair-deficient mice like dietary restriction does.
Article
Geriatrics & Gerontology
Kun Xiao, Lili Song, Yishuai Li, Congjun Li, Shicui Zhang
Summary: Microplastics (MPs) are widely present in aquatic and terrestrial ecosystems, posing an increasingly serious threat to human health. Many recent studies have examined the biological effects of MPs on animal and plant life, but there is a lack of information on the effects of MPs on aging and lifespan in vertebrate species. In this study, we confirmed the bioavailability of MPs through oral delivery in the annual fish N. guentheri, and for the first time, showed that administration of MPs not only shortened lifespan but also accelerated the development of age-related biomarkers. We also demonstrated that administration of MPs induced oxidative stress, suppressed antioxidant enzymes, reduced digestive enzymes, and caused hepatic dysfunction.
Article
Multidisciplinary Sciences
Jihao Mo, Zhenzhen Zhang, Xiaowei Wang, Miaomiao Wang, Ning Sun, Lei Wang, Meimei Wang
Summary: A high glucose diet extends the lifespan of aged worms dependent on oxidative stress resistance. The highly expressed genes gpdh-1 and col-92 are associated with oxidative stress response in worms fed high glucose diet. Intestinal gpdh-1 is essential for the lifespan extension induced by high glucose diet in aged worms.
Article
Food Science & Technology
Hui Shi, Xuqiao Hu, Hang Zheng, Chunlei Li, Lianli Sun, Zhongyi Guo, Weijuan Huang, Rongmin Yu, Liyan Song, Jianhua Zhu
Summary: Two novel antioxidant peptides, D2-G1S-1 and G2-G1S-2, identified from Arca subcrenata exhibited potent antioxidant activities, extending the mean lifespan of Caenorhabditis elegans and improving age-associated physiological functions. These peptides could potentially be developed as cosmetics additives.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Ting Wang, Mei Jing, Ting Zhang, Zaijun Zhang, Yewei Sun, Yuqiang Wang
Summary: TBN can extend the lifespan of C. elegans, promote age-related health indicators, restore mitochondrial function, and significantly reduce ROS levels and superoxide accumulation in C. elegans.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qian Wang, Jingsong Wu, Jing Huang, Lijun Yang, Jin Tao, Jintao Nie, Jiayuan Zhao, Ya-nan Wang
Summary: Cremastra appendiculata polysaccharide (CAP) has potential anti-aging and stress resistance effects. CAP primarily comprises mannose and glucose and exhibits antioxidant activity in vitro. In vivo, CAP prolongs the lifespan of Caenorhabditis elegans in a concentration-dependent manner and enhances antioxidant enzyme activity and stress resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Juan A. Godoy, Juvenal A. Rios, Pol Picon-Pages, Victor Herrera-Fernandez, Bronte Swaby, Giulia Crepin, Ruben Vicente, Jose M. Fernandez-Fernandez, Francisco J. Munoz
Summary: Mitochondria play critical roles in neurons by regulating neurotransmission and synaptic plasticity through ATP supply, calcium homeostasis, redox balance control, and apoptosis. Their functional integrity is mainly maintained by mitostasis, involving processes like mitochondrial transport, anchoring, fusion, and fission, regulated by various signaling pathways. The communication between mitochondria and the endoplasmic reticulum (ER) via mitochondria-associated membranes (MAMs) is crucial for Ca2+ buffering. Alterations in mitochondrial activity can lead to increased production of reactive oxygen species, disturbance in physiological metabolism, and mitochondrial dysfunction resulting in cell death through apoptosis.
Article
Nanoscience & Nanotechnology
Heba Ghamry, Mustafa Shukry, Mohamed A. Kassab, Foad A. Farrag, Nagi M. El-Shafai, Enas Elgendy, Amany N. Ibrahim, Salwa A. Elgendy, Ali Behairy, Samah F. Ibrahim, Florin Imbrea, Florin Crista, Mohamed Abdo, Inas A. Ahmed, Marwa H. Muhammad, Hala Anwer, Ahmed Abdeen
Summary: The study found that Arthrospira platensis nanoparticles (NSP) can protect rats from aging injuries and alleviate oxidative changes caused by D-galactose (D-gal). This suggests that NSP may be a promising natural protective compound that can prevent aging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Immunology
Jiali Fang, Yuhe Guo, Wei Yin, Lei Zhang, Guanghui Li, Junjie Ma, Lu Xu, Yunyi Xiong, Luhao Liu, Weiting Zhang, Zheng Chen
Summary: In this study, the potential therapeutic effects of neoxanthin on chronic renal failure were investigated. It was found that neoxanthin could delay the progression of the disease and alleviate aging and fibrosis caused by chronic renal failure.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Monira Pervin, Keiko Unno, Tomokazu Konishi, Yoriyuki Nakamura
Summary: The study showed that dietary L-arginine can reduce stress-induced brain damage and slow down aging in psychosocially stress-loaded senescence-accelerated (SAMP10) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Taylor C. Wallace, Regan L. Bailey, Joan Lappe, Kimberly O. O'Brien, Ding Ding Wang, Shivani Sahni, Connie M. Weaver
Summary: The role of dairy products in long-term bone health and fracture prevention remains controversial, with some studies suggesting potential risks associated with dairy consumption. Evidence supports a moderate effect of dairy consumption on bone density in middle-aged to older adults, while insufficient evidence exists for its effects on other age groups. Further research is needed to better understand the impact of dairy consumption on bone health across different age groups and ethnicities.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Nutrition & Dietetics
Kazutoyo Yoda, Xiaocum Sun, Manabu Kawase, Akira Kubota, Kenji Miyazawa, Gaku Harata, Masataka Hosoda, Masaru Hiramatsu, Fang He, Michael B. Zemel
BRITISH JOURNAL OF NUTRITION
(2015)
Article
Endocrinology & Metabolism
Lizhi Fu, Antje Bruckbauer, Fenfen Li, Qiang Cao, Xin Cui, Rui Wu, Hang Shi, Michael B. Zemel, Bingzhong Xue
METABOLISM-CLINICAL AND EXPERIMENTAL
(2015)
Article
Endocrinology & Metabolism
Lizhi Fu, Antje Bruckbauer, Fenfen Li, Qiang Cao, Xin Cui, Rui Wu, Hang Shi, Michael B. Zemel, Bingzhong Xue
METABOLISM-CLINICAL AND EXPERIMENTAL
(2015)
Article
Endocrinology & Metabolism
Lizhi Fu, Fenfen Li, Antje Bruckbauer, Qiang Cao, Xin Cui, Rui Wu, Hang Shi, Bingzhong Xue, Michael B. Zemel
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2015)
Article
Endocrinology & Metabolism
Jheelam Banerjee, Antje Bruckbauer, Michael B. Zemel
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Article
Gastroenterology & Hepatology
N. Chalasani, R. Vuppalanchi, M. Rinella, M. S. Middleton, M. S. Siddiqui, A. S. Barritt, O. Kolterman, O. Flores, C. Alonso, M. Iruarrizaga-Lejarreta, R. Gil-Redondo, C. B. Sirlin, M. B. Zemel
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Nutrition & Dietetics
Antje Bruckbauer, Michael B. Zemel, Teresa Thorpe, Murthy R. Akula, Alan C. Stuckey, Dustin Osborne, Emily B. Martin, Stephen Kennel, Jonathan S. Wall
NUTRITION & METABOLISM
(2012)
Article
Multidisciplinary Sciences
Antje Bruckbauer, Michael B. Zemel
Article
Nutrition & Dietetics
Michael B. Zemel, Antje Bruckbauer
Article
Endocrinology & Metabolism
Antje Bruckbauer, Michael B. Zemel
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2013)
Article
Endocrinology & Metabolism
Michael B. Zemel, Ntje Bruckbauer
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2013)
Article
Endocrinology & Metabolism
Michael B. Zemel, Orville Kolterman, Mary Rinella, Raj Vuppalanchi, Omar Flores, A. Sidney Barritt, Mohammad Siddiqui, Naga Chalasani
Article
Cardiac & Cardiovascular Systems
Antje Bruckbauer, Jheelam Banerjee, Quiang Cao, Xin Cui, Jia Jing, Lin Zha, Fenfen Li, Bingzhong Xue, Hang Shi, Michael B. Zemel
AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE
(2017)
Proceedings Paper
Nutrition & Dietetics
Stuart M. Phillips, Michael B. Zemel
SPORTS NUTRITION: MORE THAN JUST CALORIES - TRIGGERS FOR ADAPTATION
(2011)
Article
Nutrition & Dietetics
Chunzi Liang, Benjamin J. Curry, Patricia L. Brown, Michael B. Zemel
JOURNAL OF NUTRITION AND METABOLISM
(2014)