Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters

Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

(2018) N. Chalasani et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

(2018) Amedeo Lonardo et al.   JOURNAL OF HEPATOLOGY

Screening for Obesity and Intervention for Weight Management in Children and Adolescents

(2017) Elizabeth A. O’Connor et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Response to Letter: “Pediatric Obesity—Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline”

(2017) Dennis M. Styne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial

(2017) Belén Pastor-Villaescusa et al.   PEDIATRICS

Delineation of body mass index trajectory predicting lowest risk of mortality in U.S. men using generalized additive mixed model

(2016) Ming Ding et al.   ANNALS OF EPIDEMIOLOGY

Metformin: an Old Therapy that Deserves a New Indication for the Treatment of Obesity

(2016) L. I. Igel et al.   Current Atherosclerosis Reports

Trends in Obesity Among Adults in the United States, 2005 to 2014

(2016) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

(2016) Emanuele Di Angelantonio et al.   LANCET

Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans

(2016) Jheelam Banerjee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice

(2015) Lizhi Fu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice

(2015) Lizhi Fu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer

(2015) Anindita Das et al.   PHARMACOLOGY & THERAPEUTICS

Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling

(2014) Saisudha Koka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirtuin-Mediated Metabolism in Muscle Cells and Adipocytes

(2014) Antje Bruckbauer et al.   PLoS One

Obesity and US Mortality Risk Over the Adult Life Course

(2013) R. K. Masters et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Sildenafil Promotes eNOS Activation and Inhibits NADPH Oxidase in the Transgenic Sickle Cell Mouse Penis

(2013) Biljana Musicki et al.   Journal of Sexual Medicine

Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects

(2013) Michael Zemel et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts

(2012) Saisudha Koka et al.   BASIC RESEARCH IN CARDIOLOGY

The Pleiotropic Effects of Phosphodiesterase 5 Inhibitors on Function and Safety in Patients With Cardiovascular Disease and Hypertension

(2012) Steven G. Chrysant et al.   Journal of Clinical Hypertension

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

(2012) Antje Bruckbauer et al.   Nutrition & Metabolism

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension

(2010) Gautam Ramani   Drug Design Development and Therapy

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database

(2009) F. Giuliano et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

(2009) Prospective Studies Collaboration   LANCET

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

The Medical Risks of Obesity

(2009) Xavier Pi-Sunyer   POSTGRADUATE MEDICINE

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA