Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE)

Beta-secretase as a target for Alzheimer’s disease drug discovery: an overview of in vitro methods for characterization of inhibitors

(2011) Francesca Mancini et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Comparison of Analytical Platforms for Cerebrospinal Fluid Measures of β-Amyloid 1-42, Total tau, and P-tau181 for Identifying Alzheimer Disease Amyloid Plaque Pathology

(2011) Anne M. Fagan   ARCHIVES OF NEUROLOGY

Dynamics in the Active Site of β-Secretase: A Network Analysis of Atomistic Simulations

(2011) Sabyashachi Mishra et al.   BIOCHEMISTRY

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation

(2011) Lujia Zhou et al.   EMBO Molecular Medicine

The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

(2011) Robert Vassar et al.   Alzheimers Research & Therapy

Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent β-secretase inhibitory leads

(2010) Afaf Al-Nadaf et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Superimposing the 27 crystal protein/inhibitor complexes of β-secretase to calculate the binding affinities by the linear interaction energy method

(2010) Shu Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Association among Amyloid Plaque, Lipid, and Creatine in Hippocampus of TgCRND8 Mouse Model for Alzheimer Disease

(2010) Alexandra Kuzyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

(2010) Bin Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors with activity in vivo

(2009) Rainer Machauer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel non-peptide β-secretase inhibitors derived from structure-based virtual screening and bioassay

(2009) Weijun Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-Secretase Inhibitor Potency Is Decreased by Aberrant β-Cleavage Location of the “Swedish Mutant” Amyloid Precursor Protein

(2009) Hidekuni Yamakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Protonation, Tautomeric, and Stereoisomeric States on Protein−Ligand Docking Results

(2009) Tim ten Brink et al.   Journal of Chemical Information and Modeling

Comparative binding energy analysis for binding affinity and target selectivity prediction

(2009) Stefan Henrich et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

gCOMBINE: A graphical user interface to perform structure-based comparative binding energy (COMBINE) analysis on a set of ligand-receptor complexes

(2009) Rubén Gil-Redondo et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues

(2008) Marcus Bäck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors

(2008) J.N. Cumming et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character

(2008) Brian Clarke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase‡

(2008) James C. Barrow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability†

(2008) Nicolas Charrier et al.   JOURNAL OF MEDICINAL CHEMISTRY

β-Secretase as a therapeutic target for Alzheimer’s disease

(2008) Arun K. Ghosh et al.   Neurotherapeutics

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

(2007) Derek C. Cole et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors

(2007) U. Iserloh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS