期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 11, 页码 3313-3317出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm800138h
关键词
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BACE-1 inhibition has the potential to provide a disease-modifying therapy for the treatment of Alzheimer's disease. Optimization of a first generation of BACE-1 inhibitors led to the discovery of novel hydroxyethylamines (HEAs) bearing a tricyclic nonprime side. These derivatives have nanomolar cell potency and are orally bioavailable.
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