ATG16L1: A multifunctional susceptibility factor in Crohn disease

Human autophagy geneATG16L1is post-transcriptionally regulated byMIR142-3p

(2014) Zili Zhai et al.   Autophagy

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

Autophagy genes variants and paediatric Crohn's disease phenotype: A single-centre experience

(2014) Caterina Strisciuglio et al.   DIGESTIVE AND LIVER DISEASE

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inflammatory bowel disease: Pathogenesis

(2014) Yi-Zhen Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

ATG16L1andNOD2polymorphisms enhance phagocytosis in monocytes of Crohn’s disease patients

(2014) Simone CS Wolfkamp   WORLD JOURNAL OF GASTROENTEROLOGY

Syntaxin 17

(2013) Eisuke Itakura et al.   Autophagy

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress

(2013) Eveline Hoefkens et al.   Autophagy

ATG16L1 meets ATG9 in recycling endosomes

(2013) Claudia Puri et al.   Autophagy

Evolution of the unfolded protein response

(2013) Julie Hollien   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

A Deficiency in the Autophagy Gene Atg16L1 Enhances Resistance to Enteric Bacterial Infection

(2013) Amanda M. Marchiando et al.   Cell Host & Microbe

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

A current perspective of autophagosome biogenesis

(2013) Shusaku T Shibutani et al.   CELL RESEARCH

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation

(2013) Eszter Zavodszky et al.   FEBS LETTERS

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection

(2013) Kara L. Conway et al.   GASTROENTEROLOGY

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Crohn's Disease–Associated Adherent Invasive Escherichia coli Modulate Levels of microRNAs in Intestinal Epithelial Cells to Reduce Autophagy

(2013) Hang Thi Thu Nguyen et al.   GASTROENTEROLOGY

Many Inflammatory Bowel Disease Risk Loci Include Regions That Regulate Gene Expression in Immune Cells and the Intestinal Epithelium

(2013) Michal Mokry et al.   GASTROENTEROLOGY

Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease

(2013) Ana Gutiérrez et al.   GUT

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

(2013) Suk-Kyun Yang et al.   GUT

Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease

(2013) J Jasper Deuring et al.   GUT

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

(2013) Matthew T. Sorbara et al.   IMMUNITY

Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis

(2013) Hui Yin et al.   IMMUNOLOGY

Autophagy in the immune system

(2013) Daniel J. Puleston et al.   IMMUNOLOGY

T300A Variant of Autophagy ATG16L1 Gene is Associated with Decreased Antigen Sampling and Processing by Dendritic Cells in Pediatric Crohnʼs Disease

(2013) Caterina Strisciuglio et al.   INFLAMMATORY BOWEL DISEASES

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

(2013) Yasuhiro Maejima et al.   NATURE MEDICINE

Autophagy: a new target or an old strategy for the treatment of Crohn's disease?

(2013) Kris Nys et al.   Nature Reviews Gastroenterology & Hepatology

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association between Variants of the Autophagy Related Gene – IRGM and Susceptibility to Crohn’s Disease and Ulcerative Colitis: A Meta-Analysis

(2013) Xiao Cheng Lu et al.   PLoS One

Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage

(2013) Martina Wirth et al.   SEMINARS IN CANCER BIOLOGY

Intestinal Epithelium and Autophagy: Partners in Gut Homeostasis

(2013) Sarron Randall-Demllo et al.   Frontiers in Immunology

Debug Your Bugs – How NLRs Shape Intestinal Host-Microbe Interactions

(2013) Simone Lipinski et al.   Frontiers in Immunology

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Muramyl dipeptide responsive pathways in Crohn’s disease: from NOD2 and beyond

(2012) Mohammad Salem et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response

(2012) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells From Patients With Crohn's Disease

(2012) Élodie Thachil et al.   GASTROENTEROLOGY

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

(2012) Manon E. Wildenberg et al.   GASTROENTEROLOGY

Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

(2012) Deepa Raju et al.   GASTROENTEROLOGY

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohnʼs disease

(2012) Travis B. Murdoch et al.   INFLAMMATORY BOWEL DISEASES

Impaired autophagy leads to abnormal dendritic cell–epithelial cell interactions

(2012) Caterina Strisciuglio et al.   Journal of Crohns & Colitis

Regulation of Inflammatory Response by 3-Methyladenine Involves the Coordinative Actions on Akt and Glycogen Synthase Kinase 3  Rather than Autophagy

(2012) Y.-C. Lin et al.   JOURNAL OF IMMUNOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex

(2011) Koutaro Ishibashi et al.   Autophagy

LC3 and GATE-16 N Termini Mediate Membrane Fusion Processes Required for Autophagosome Biogenesis

(2011) Hilla Weidberg et al.   DEVELOPMENTAL CELL

ATG16L1 gene polymorphisms are associated with palmoplantar pustulosis

(2011) Konstantinos Douroudis et al.   HUMAN IMMUNOLOGY

Transmission Distortion in Crohnʼs Disease Risk Gene ATG16L1 Leads to Sex Difference in Disease Association

(2011) Linda Y. Liu et al.   INFLAMMATORY BOWEL DISEASES

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

(2011) Tania O. Crişan et al.   PLoS One

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila

(2010) Sze Man Tung et al.   CELLULAR MICROBIOLOGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

(2010) Liesbet Henckaerts et al.   INFLAMMATORY BOWEL DISEASES

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

NOD2/CARD15,ATG16L1andIL23Rgene polymorphisms and childhood-onset of Crohn’s disease

(2010) Maria Gazouli   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn’s disease in German children

(2009) Martin Lacher et al.   ACTA PAEDIATRICA

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

(2009) Ken Cadwell et al.   Autophagy

Contribution of IL23R but not ATG16L1 to Crohnʼs disease susceptibility in Koreans

(2009) Suk-Kyun Yang et al.   INFLAMMATORY BOWEL DISEASES

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance

(2009) K. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

(2008) Rinse K. Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Multicenter, Randomized, Double-Blind Trial of EverolimusVersusAzathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

(2008) Walter Reinisch et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TheATG16L1Gene Variants rs2241879 and rs2241880 (T300A) Are Strongly Associated With Susceptibility to Crohn's Disease in the German Population

(2008) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Autophagy gene ATG16L1 but not IRGM is associated with Crohnʼs disease in Canadian children

(2008) Devendra K. Amre et al.   INFLAMMATORY BOWEL DISEASES

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Autophagic control of listeria through intracellular innate immune recognition in drosophila

(2008) Tamaki Yano et al.   NATURE IMMUNOLOGY

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE

Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohnʼs disease in Northern Europe

(2007) J. Van Limbergen et al.   INFLAMMATORY BOWEL DISEASES