Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress

Environment and the Inflammatory Bowel Diseases

(2016) Alexandra Frolkis et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Lower-Order Effects Adjustment in Quantitative Traits Model-Based Multifactor Dimensionality Reduction

(2012) Jestinah M. Mahachie John et al.   PLoS One

Crohn's disease: NOD2, autophagy and ER stress converge

(2011) T. Fritz et al.   GUT

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives

(2011) M. Joossens et al.   GUT

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis

(2011) Junji Umeno et al.   INFLAMMATORY BOWEL DISEASES

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

Model-Based Multifactor Dimensionality Reduction for detecting epistasis in case-control data in the presence of noise

(2010) Tom Cattaert et al.   ANNALS OF HUMAN GENETICS

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

(2010) Liesbet Henckaerts et al.   INFLAMMATORY BOWEL DISEASES

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Genetics of childhood-onset inflammatory bowel disease

(2010) Paul Henderson et al.   INFLAMMATORY BOWEL DISEASES

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Parkinson disease, LRRK2 and the endocytic-autophagic pathway

(2009) Javier Alegre-Abarrategui et al.   Autophagy

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

(2009) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

(2009) R J Palomino-Morales et al.   GENES AND IMMUNITY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort

(2008) R K Weersma et al.   GUT

Autophagy gene ATG16L1 but not IRGM is associated with Crohnʼs disease in Canadian children

(2008) Devendra K. Amre et al.   INFLAMMATORY BOWEL DISEASES

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One