From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine
出版年份 2012 全文链接
标题
From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine
作者
关键词
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出版物
Wiley Interdisciplinary Reviews-Systems Biology and Medicine
Volume 4, Issue 6, Pages 585-598
出版商
Wiley
发表日期
2012-08-16
DOI
10.1002/wsbm.1186
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Geno2pheno[454]: A Web Server for the Prediction of HIV-1 Coreceptor Usage from Next-Generation Sequencing Data
- (2012) Alexander Thielen et al. INTERVIROLOGY
- Bioinformatical Assistance of Selecting Anti-HIV Therapies: Where Do We Stand?
- (2012) Thomas Lengauer INTERVIROLOGY
- Predicting Response to Antiretroviral Treatment by Machine Learning: The EuResist Project
- (2012) Maurizio Zazzi et al. INTERVIROLOGY
- The HIVdb System for HIV-1 Genotypic Resistance Interpretation
- (2012) Michele W. Tang et al. INTERVIROLOGY
- The “Virtual Patient” system: modeling cancer using deep sequencing technologies for personalized cancer treatment
- (2012) Alexander Kühn et al. Journal fur Verbraucherschutz und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety
- Molecular Dynamics of HIV1-Integrase in Complex with93del—A Structural Perspective on the Mechanism of Inhibition
- (2012) Miriam Sgobba et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
- (2012) S. Wan et al. MOLECULAR CANCER THERAPEUTICS
- NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care
- (2012) E. E. Schadt et al. Science Translational Medicine
- Multiscale Cancer Modeling
- (2011) Thomas S. Deisboeck et al. Annual Review of Biomedical Engineering
- Molecular Dynamics Approaches Estimate the Binding Energy of HIV-1 Integrase Inhibitors and Correlate withIn VitroActivity
- (2011) Barry C. Johnson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Alchemical free energy methods for drug discovery: progress and challenges
- (2011) John D Chodera et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Resolution of Discordant HIV-1 Protease Resistance Rankings Using Molecular Dynamics Simulations
- (2011) David W. Wright et al. Journal of Chemical Information and Modeling
- Molecular dynamics simulation reveals structural and thermodynamic features of kinase activation by cancer mutations within the epidermal growth factor receptor
- (2011) Shunzhou Wan et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Binding of novel fullerene inhibitors to HIV-1 protease: insight through molecular dynamics and molecular mechanics Poisson–Boltzmann surface area calculations
- (2011) Haralambos Tzoupis et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Reaction Kinetics of Catalyzed Competitive Heteropolymer Cleavage
- (2011) S. Kashif Sadiq et al. JOURNAL OF PHYSICAL CHEMISTRY B
- How Does a Drug Molecule Find Its Target Binding Site?
- (2011) Yibing Shan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rapid and accurate ranking of binding affinities of epidermal growth factor receptor sequences with selected lung cancer drugs
- (2011) S. Wan et al. Journal of the Royal Society Interface
- Global landscape of HIV–human protein complexes
- (2011) Stefanie Jäger et al. NATURE
- Computational Analysis of HIV-1 Resistance Based on Gene Expression Profiles and the Virus-Host Interaction Network
- (2011) Tao Huang et al. PLoS One
- Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease
- (2011) Zhigang Liu et al. PROTEIN JOURNAL
- Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm
- (2011) K. Marias et al. Interface Focus
- Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir
- (2011) Li Xie et al. PLoS Computational Biology
- Network-Based Prediction and Analysis of HIV Dependency Factors
- (2011) T. M. Murali et al. PLoS Computational Biology
- Towards Accurate Free Energy Calculations in Ligand Protein-Binding Studies
- (2010) Thomas Steinbrecher et al. CURRENT MEDICINAL CHEMISTRY
- Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors
- (2010) Francesca Ceccherini-Silberstein et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- HIV-1 TAR RNA Spontaneously Undergoes Relevant Apo-to-Holo Conformational Transitions in Molecular Dynamics and Constrained Geometrical Simulations
- (2010) Simone Fulle et al. Journal of Chemical Information and Modeling
- Accurate Ensemble Molecular Dynamics Binding Free Energy Ranking of Multidrug-Resistant HIV-1 Proteases
- (2010) S. Kashif Sadiq et al. Journal of Chemical Information and Modeling
- Understanding the HIV-1 protease nelfinavir resistance mutation D30N in subtypes B and C through molecular dynamics simulations
- (2010) Rosemberg O. Soares et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Challenges and advances in computational docking: 2009 in review
- (2010) Elizabeth Yuriev et al. JOURNAL OF MOLECULAR RECOGNITION
- Computational Mutation Scanning and Drug Resistance Mechanisms of HIV-1 Protease Inhibitors
- (2010) Ge-Fei Hao et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Retroviral intasome assembly and inhibition of DNA strand transfer
- (2010) Stephen Hare et al. NATURE
- Rationalisation of the Differences between APOBEC3G Structures from Crystallography and NMR Studies by Molecular Dynamics Simulations
- (2010) Flavia Autore et al. PLoS One
- Structure-based modeling of the functional HIV-1 intasome and its inhibition
- (2010) L. Krishnan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CCR5: From Natural Resistance to a New Anti-HIV Strategy
- (2010) Lucia Lopalco Viruses-Basel
- Drug Discovery in a Multidimensional World: Systems, Patterns, and Networks
- (2010) Joel T. Dudley et al. Journal of Cardiovascular Translational Research
- Hybrid models of tumor growth
- (2010) Katarzyna A. Rejniak et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Cancer systems biology: a network modeling perspective
- (2009) P. K. Kreeger et al. CARCINOGENESIS
- The value of drug repositioning in the current pharmaceutical market
- (2009) E.L. Tobinick DRUG NEWS & PERSPECTIVES
- Impact on Replicative Fitness of the G48E Substitution in the Protease of HIV-1
- (2009) Jean-Marie Zimmer et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Molecular Dynamics and Free Energy Studies on the Wild-Type and Mutated HIV-1 Protease Complexed with Four Approved Drugs: Mechanism of Binding and Drug Resistance
- (2009) Stefano Alcaro et al. Journal of Chemical Information and Modeling
- Elucidating the Inhibition Mechanism of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors through Multicopy Molecular Dynamics Simulations
- (2009) Anthony Ivetac et al. JOURNAL OF MOLECULAR BIOLOGY
- Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
- (2009) C. M. Parry et al. JOURNAL OF VIROLOGY
- HIV decision support: from molecule to man
- (2009) P.M.A. Sloot et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding
- (2009) A. Bakan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Binding of Small-Molecule Ligands to Proteins: “What You See” Is Not Always “What You Get”
- (2009) David L. Mobley et al. STRUCTURE
- Multiscale modeling for biologists
- (2009) Martin Meier-Schellersheim et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Minority Quasispecies of Drug‐Resistant HIV‐1 That Lead to Early Therapy Failure in Treatment‐Naive and ‐Adherent Patients
- (2008) Karin J. Metzner et al. CLINICAL INFECTIOUS DISEASES
- Anton, a special-purpose machine for molecular dynamics simulation
- (2008) David E. Shaw et al. COMMUNICATIONS OF THE ACM
- Binding modes of CCR5-targetting HIV entry inhibitors: Partial and full antagonists
- (2008) Ting Wang et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Rapid and Accurate Prediction of Binding Free Energies for Saquinavir-Bound HIV-1 Proteases
- (2008) Ileana Stoica et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Turning promiscuous kinase inhibitors into safer drugs
- (2008) Xi Zhang et al. TRENDS IN BIOTECHNOLOGY
- In silico cancer modeling: is it ready for prime time?
- (2008) Thomas S Deisboeck et al. Nature clinical practice. Oncology
- Rapid structural fluctuations of the free HIV protease flaps in solution: Relationship to crystal structures and comparison with predictions of dynamics calculations
- (2002) Darón I. Freedberg et al. PROTEIN SCIENCE
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