FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia

Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells

(2014) Zhi-Hua Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

FGFR3 induces degradation of BMP type I receptor to regulate skeletal development

(2014) Huabing Qi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of autophagy: Modulation of the size and number of autophagosomes

(2014) Meiyan Jin et al.   FEBS LETTERS

The Regulation of the Autophagic Network and Its Implications for Human Disease

(2014) Jing Yang et al.   International Journal of Biological Sciences

Statin treatment rescues FGFR3 skeletal dysplasia phenotypes

(2014) Akihiro Yamashita et al.   NATURE

Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation

(2013) Mian Zhang et al.   APOPTOSIS

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress

(2013) Faith Hall-Glenn et al.   Journal of Cell Communication and Signaling

Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating Achondroplasia

(2012) Florence Lorget et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia

(2012) Y. Xie et al.   HUMAN MOLECULAR GENETICS

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia

(2012) Min Jin et al.   HUMAN MOLECULAR GENETICS

Generation of Fgfr3 Conditional Knockout Mice

(2012) Nan Su et al.   International Journal of Biological Sciences

FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts

(2012) Xiang Lin et al.   International Journal of Biological Sciences

Role of FGFs/FGFRs in skeletal development and bone regeneration

(2012) Xiaolan Du et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection

(2011) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

(2011) Hiroshi Sasaki et al.   ARTHRITIS AND RHEUMATISM

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

FRS2α-Mediated FGF Signals Suppress Premature Differentiation of Cardiac Stem Cells Through Regulating Autophagy Activity

(2011) Jue Zhang et al.   CIRCULATION RESEARCH

Sixteen years and counting: The current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias

(2011) Silvie Foldynova-Trantirkova et al.   HUMAN MUTATION

A Pilot Study of Discontinuous, Insulin-Like Growth Factor 1–Dosing Growth Hormone Treatment in Young Children with FGFR3 N540K-Mutated Hypochondroplasia

(2011) Anya Rothenbuhler et al.   JOURNAL OF PEDIATRICS

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

(2010) Pavel Krejci et al.   BONE

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy

(2009) Jolene Bohensky et al.   ARTHRITIS AND RHEUMATISM

Self-eating in skeletal development: Implications for lysosomal storage disorders

(2009) Carmine Settembre et al.   Autophagy

Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal Dysplasias

(2009) Akihiro Yasoda et al.   ENDOCRINOLOGY

Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

(2009) Jolene Bohensky et al.   PEDIATRIC NEPHROLOGY

Autophagy: A New Phase in the Maturation of Growth Plate Chondrocytes Is Regulated by HIF, mTOR and AMP Kinase

(2008) Vickram Srinivas et al.   CELLS TISSUES ORGANS

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification

(2008) C. Settembre et al.   GENES & DEVELOPMENT

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols

Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage

(2008) Pavel Krejci et al.   PLoS One

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

(2008) B. D. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA