The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

Identification and Characterization of the First Small Molecule Inhibitor of MDMX

(2010) Damon Reed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

(2010) Mark Demma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

(2009) Ramzi M Mohammad et al.   Molecular Cancer

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

p53 Activation: A Case against Sir

(2008) Christopher L. Brooks et al.   CANCER CELL

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

The dark side of a tumor suppressor: anti-apoptotic p53

(2008) R U Jänicke et al.   CELL DEATH AND DIFFERENTIATION

Does control of mutant p53 by Mdm2 complicate cancer therapy?

(2008) C. Prives et al.   GENES & DEVELOPMENT

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

Cancer cells suppress p53 in adjacent fibroblasts

(2008) J Bar et al.   ONCOGENE

TP53 Status and Response to Chemotherapy in Breast Cancer

(2008) Philippe Bertheau et al.   PATHOBIOLOGY

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

(2008) F. M. Boeckler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA