The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies

(2012) Z. Y. Xu-Monette et al.   BLOOD

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells

(2012) T. Asai et al.   BLOOD

Do reactive oxygen species play a role in myeloid leukemias?

(2011) P. S. Hole et al.   BLOOD

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

(2011) Y. V. Wang et al.   GENES & DEVELOPMENT

Validation of MdmX as a therapeutic target for reactivating p53 in tumors

(2011) D. Garcia et al.   GENES & DEVELOPMENT

Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models

(2011) Tamara Terzian et al.   JOURNAL OF PATHOLOGY

p53 Lesions in Leukemic Transformation

(2011) Ashot Harutyunyan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

(2011) V. Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal Models of Diamond Blackfan Anemia

(2011) Kelly A. McGowan et al.   SEMINARS IN HEMATOLOGY

Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies

(2011) Matthew R. Warr et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Diamond Blackfan Anemia

(2011) S. Ball   Hematology-American Society of Hematology Education Program

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose  -irradiation

(2010) H. Yu et al.   BLOOD

A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia

(2010) E. E. Devlin et al.   BLOOD

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

(2010) L. Shao et al.   BLOOD

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

(2010) S. Dutt et al.   BLOOD

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects

(2010) Nadia Danilova et al.   BRITISH JOURNAL OF HAEMATOLOGY

A High-Frequency Regulatory Polymorphism in the p53 Pathway Accelerates Tumor Development

(2010) Sean M. Post et al.   CANCER CELL

Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4

(2010) S. Xiong et al.   CANCER RESEARCH

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

(2010) Katerina I. Leonova et al.   CELL CYCLE

p53-family proteins and their regulators: hubs and spokes in tumor suppression

(2010) L Collavin et al.   CELL DEATH AND DIFFERENTIATION

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

Diamond Blackfan anemia 2008–2009: broadening the scope of ribosome biogenesis disorders

(2010) Jeffrey M Lipton et al.   CURRENT OPINION IN PEDIATRICS

Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation

(2010) D. Oscier et al.   HAEMATOLOGICA

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

Puma is required for p53-induced depletion of adult stem cells

(2010) Dongping Liu et al.   NATURE CELL BIOLOGY

Pathologies Associated with the p53 Response

(2010) A. V. Gudkov et al.   Cold Spring Harbor Perspectives in Biology

Irradiation Selects for p53-Deficient Hematopoietic Progenitors

(2010) Andriy Marusyk et al.   PLOS BIOLOGY

Pathogenesis of the erythroid failure in Diamond Blackfan anaemia

(2009) Colin A. Sieff et al.   BRITISH JOURNAL OF HAEMATOLOGY

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

(2009) Sridevi Yadavilli et al.   DNA REPAIR

The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia

(2009) H Seifert et al.   LEUKEMIA

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

(2009) Yan Zhu et al.   MOLECULAR CELL

The promises and perils of p53

(2009) Valery Krizhanovsky et al.   NATURE

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

(2009) George Hinkal et al.   PLoS One

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

(2009) D. G. Kirsch et al.   SCIENCE

The Regulation of the p53-mediated Stress Response by MDM2 and MDM4

(2009) M. E. Perry   Cold Spring Harbor Perspectives in Biology

Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia

(2008) J. E. Farrar et al.   BLOOD

Mutated and non-mutated TP53 as targets in the treatment of leukaemia

(2008) H. Nahi et al.   BRITISH JOURNAL OF HAEMATOLOGY

High-Resolution Array-Based Comparative Genomic Hybridization of Bladder Cancers Identifies Mouse Double Minute 4 (MDM4) as an Amplification Target Exclusive of MDM2 and TP53

(2008) A. Veerakumarasivam et al.   CLINICAL CANCER RESEARCH

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

(2008) Jichun Chen et al.   EXPERIMENTAL HEMATOLOGY

Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder

(2008) V. Choesmel et al.   HUMAN MOLECULAR GENETICS

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

(2008) Yaara Ofir-Rosenfeld et al.   MOLECULAR CELL

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

(2008) Omobolaji O. Akala et al.   NATURE

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE