Article
Engineering, Biomedical
Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a photo-crosslinked multifunctional antibacterial adhesive hemostatic hydrogel dressing that can disinfect drug-resistant bacteria and promote wound healing. Through various tests, it showed good hemostatic and antibacterial properties, and proved to be more effective than current commercially available dressings in treating infected wounds.
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Konstantin Simon, Gila Oberender, Alexander Roloff
Summary: Tape stripping is a common method used in studies on drug penetration through the skin, but the amount of stratum corneum removed by each tape strip is still under debate. Some studies suggest that the amount of stratum corneum decreases with increasing depth, while others find a constant removal rate.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Qiankun Zeng, Xiaoliang Qi, Guoyue Shi, Min Zhang, Hossam Haick
Summary: This article reviews the importance of wound dressings based on nanomaterials in wound treatment and highlights their functional advantages and smart development trends. It also explores the challenges and opportunities associated with nanomaterial-based wound dressings in clinical practice.
Article
Multidisciplinary Sciences
Nichola J. Starr, Mohammed H. Khan, Max K. Edney, Gustavo F. Trindade, Stefanie Kern, Alexander Pirkl, Matthias Kleine-Boymann, Christopher Elms, Mark M. O'Mahony, Mike Bell, Morgan R. Alexander, David J. Scurr
Summary: In this study, the 3D OrbiSIMS technique was used to analyze the molecular chemistry of human skin tissue and provide unprecedented details about the nonhomogeneity of the stratum corneum. The analysis resolved debates about chemical gradients within the epidermis and revealed similarities in epidermal compounds between human and porcine skin. Additionally, the study demonstrated the permeation of an antiaging peptide into the human stratum corneum.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Joke A. Bouwstra, Andreea Nadaban, Wim Bras, Clare McCabe, Annette Bunge, Gerrit S. Gooris
Summary: The barrier function of the skin is primarily located in the outermost layer called stratum corneum (SC), which contains lipid lamellae that play a crucial role in permeation of compounds. Analyzing the lipid composition is essential in understanding the skin barrier function and its impairment in inflammatory skin diseases.
PROGRESS IN LIPID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Arya Kadukkattil Ramanunny, Sheetu Wadhwa, Monica Gulati, Sachin Kumar Singh, Bhupinder Kapoor, Harish Dureja, Dinesh Kumar Chellappan, Krishnan Anand, Kamal Dua, Rubiya Khursheed, Ankit Awasthi, Rajan Kumar, Jaskiran Kaur, Leander Corrie, Narendra Kumar Pandey
Summary: Skin diseases are a significant burden on the global economy and affect patients' quality of life. Traditional treatment approaches face limitations, but nanomedicine offers efficient targeted drug delivery solutions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jiun-Wen Guo, Shiou-Hwa Jee
Summary: The treatment of inflammatory skin diseases poses challenges, with topical therapy being the first line of management. The key to success lies in the effectiveness and adaptability of the pharmaceutical formulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Claudio Malnati, Daniel Fehr, Fabrizio Spano, Mathias Bonmarin
Summary: The research suggests that skin capacitance decreases at high hydration levels, emphasizing the importance of variations in stratum corneum thickness for hydration monitoring. Additionally, the sensitivity to stratum corneum hydration levels is influenced by the electrode's geometry and dimensions, with conductance electrodes being more affected by changes in dimension than capacitance electrodes.
Article
Engineering, Biomedical
Hang Yao, Ming Wu, Liwei Lin, Zhonglian Wu, Minjun Bae, Sumin Park, Shuli Wang, Wang Zhang, Jiefeng Gao, Dongan Wang, Yuanzhe Piao
Summary: The wound healing process is often hindered by bacterial infections, leading to impaired healing. The use of adhesive hydrogels with natural antibacterial agents as wound dressings has been recognized as an effective treatment. This review summarizes studies on ingredients, preparation methods, antibacterial mechanisms, and internal factors of adhesive hydrogels, providing insights and prospects for their biomedical applications and clinical research.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Tianqi Liu, Yanfang Sun, Guohua Jiang, Wenjing Zhang, Rui Wang, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich
Summary: Diabetes chronic wound is a serious medical problem in patients with diabetes, which often leads to complications. A porcupine quill-like multilayer microneedle patch was designed to address the issues of insufficient skin adhesion and bacterial infection. The patch contains antibacterial nanoparticles and a hypoglycemic agent, and is combined with a flexible and adhesive back patching for better tissue adhesion and wound healing. The bioinspired multilayer structure of the patch shows satisfactory mechanical and antibacterial properties, making it a potential dressing platform for promoting wound healing.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Jee-hyun Hwang, Haengdueng Jeong, Nahyun Lee, Sumin Hur, Nakyum Lee, Jeong Jun Han, Hye Won Jang, Wang Keun Choi, Ki Taek Nam, Kyung-Min Lim
Summary: The study found that the ex vivo live full-thickness porcine skin model is an excellent alternative to animal experiments for research on the safety and efficacy of cosmetic ingredients. Lactobionic acid showed the best improvement in skin barrier function, and the model could measure TEWL, confirming the significant skin barrier-protective effects of PHAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Zifeng Yang, Rongkang Huang, Bingna Zheng, Wentai Guo, Chuangkun Li, Wenyi He, Yingqi Wei, Yang Du, Huaiming Wang, Dingcai Wu, Hui Wang
Summary: By grafting cationic polyelectrolyte brushes onto polydopamine/polyacrylamide hydrogels, the mechanical and antibacterial properties of the hydrogels were enhanced, leading to stable coverage, long-lasting antibacterial effects, and fast wound healing.
Review
Pharmacology & Pharmacy
Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi
Summary: Insulin is commonly delivered through subcutaneous injections for the treatment of diabetes, which can be invasive and hinder patient compliance. Transdermal delivery methods, such as microneedles and patches, offer advantages including prolonged drug release and improved patient adherence. Research in transdermal insulin delivery is ongoing, and it is expected that these systems may soon be introduced in clinical practice.
Article
Pharmacology & Pharmacy
V. H. P. Infante, P. M. B. G. Maia Campos, L. S. Calixto, M. E. Darvin, M. Kroeger, S. Schanzer, S. B. Lohan, J. Lademann, M. C. Meinke
Summary: The study evaluated and compared the rheological behavior and texture profile of two sunscreen formulations and correlated them with their SPF values, finding that the formulation with ethoxylated lanolin showed better efficacy and positive influence on skin surface deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Polymer Science
Martin Juhascik, Andrej Kovacik, Gloria Huerta-Angeles
Summary: Hyaluronan (HA) plays a crucial role in maintaining skin health, studying skin inflammatory diseases, and delivering skin drugs, with the molecular size being a significant factor in mechanisms and interactions.
