Article
Chemistry, Multidisciplinary
Ning Tang, Rongjun Zhang, Youbin Zheng, Jing Wang, Muhammad Khatib, Xue Jiang, Cheng Zhou, Rawan Omar, Walaa Saliba, Weiwei Wu, Miaomiao Yuan, Daxiang Cui, Hossam Haick
Summary: The study introduces a novel self-healing, antibacterial, and multifunctional wound dressing for sutureless wound closure and real-time monitoring. The dressing features high mechanical toughness, biocompatibility, and outstanding antibacterial activity, effectively inhibiting bacterial growth and accelerating healing. In vivo tests demonstrate that the dressing can help in wound closure and deposition of collagen, while the integrated sensor array provides real-time monitoring of temperature, pH, and glucose levels in the wound area. Ultimately, this multifunctional dressing would be valuable for personalized monitoring and treatment approaches in wound healing management.
ADVANCED MATERIALS
(2022)
Article
Cell Biology
Yuheng Zhang, Tian Li, Congying Zhao, Jinqing Li, Rong Huang, Qianru Zhang, Yongqian Li, Xueyong Li
Summary: Smart dressings, integrating biomimetic nanofibre membrane, microenvironment sensor, and GelMA + beta-cd UV-crosslinked hydrogel, not only promote wound healing by monitoring the wound microenvironment in real time, but also enhance treatment efficacy and support clinical work.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Article
Biophysics
Ze Wang, Xiaolan Ou, Lin Guan, Xingchen Li, Annan Liu, Lei Li, Andrei Zvyagin, Wenrui Qu, Bai Yang, Quan Lin
Summary: Inspired by pomegranate, this study developed a multifunctional nanocomposite wound dressing with fluorescent and photothermal properties, using Au/Ag nanodots as the core and polyvinyl alcohol hydrogel as the shell. The dressing showed excellent antibacterial and photothermal therapy effects on diabetic wounds, and could also function as a smart messenger for determining the appropriate time for dressing replacement.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
Ji-Hwan Ha, Jae Yun Kim, Dahong Kim, Junseong Ahn, Yongrok Jeong, Jiwoo Ko, Soonhyoung Hwang, Sohee Jeon, Young Jung, Jimin Gu, Hyeonseok Han, Jungrak Choi, Gihun Lee, Moonjeong Bok, Su A. Park, Yee Sook Cho, Jun-Ho Jeong, Inkyu Park
Summary: This study develops an electrospun composite micro/nanofiber-based bilayer-dressing patch with a healing-support layer and a protective/monitoring layer. The healing-support layer enhances cell regeneration and biocompatibility for rapid healing. The protective/monitoring layer exhibits excellent antimicrobial properties and visible color changes within the pH range of wound lesions, suitable for advanced wound care. Wounds on BALB/c mice heal rapidly in 12 days, and the wound state can be diagnosed by the color change of the dressing patch. This multifunctional wound dressing patch promotes wound healing and facilitates convenient wound management.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xinming Zhang, Ruijuan Lv, Lixia Chen, Ruimeng Sun, Yang Zhang, Rongtian Sheng, Ting Du, Yuhan Li, Yanfei Qi
Summary: Wound healing greatly affects patients' health and produces medical burden. Therefore, a multifunctional electrospun nanofiber dressing was developed to inhibit MRSA, drain excessive biofluid, and monitor wound pH level. The Janus dressing, with encapsulated P2W18/PLA nanofiber layer for MRSA inhibition and PSP/PAN nanofiber layer for pH indication, exhibited good biocompatibility and accelerated wound healing. This multifunctional Janus electrospun nanofiber dressing would be beneficial for wound management and treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Lirong Wang, Mengyun Zhou, Tailin Xu, Xueji Zhang
Summary: The multifunctional hydrogel wound dressing promotes wound healing by providing antibacterial, hemostatic, and adhesive properties, while also enabling real-time monitoring of wound status. The personalized wound management model accurately analyzes and evaluates wound healing and infection status using the colorimetric signal of the hydrogel dressing, achieving high accuracy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Hongshuang Guo, Ming Bai, Yingnan Zhu, Xinmeng Liu, Shu Tian, You Long, Yiming Ma, Chiyu Wen, Qingsi Li, Jing Yang, Lei Zhang
Summary: A zwitterionic skin sensor system has been developed to continuously monitor and differentiate three-stimuli-responsive information in real-time, avoiding signal interference. This system utilizes a sandwich structure to monitor temperature, mechanical, and glucose information through variations in capacitance and resistance in different layers, which can be used for smart wound dressings to monitor chronic diabetic wounds.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Alessandro Sarcinella, Saveria Femmino, Maria Felice Brizzi
Summary: This article provides an overview of preclinical data supporting the role of extracellular vesicles (EVs) in repair and regenerative processes. It highlights the importance of different EV sources and their engineering for providing a scalable and low-cost therapeutic option for tissue repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Xinghuan Lin, Hao Zhang, Shanshan Li, Lin Huang, Rongrong Zhang, Lina Zhang, Aixi Yu, Bo Duan
Summary: Metal-polyphenol networks have attracted attention for biomedical applications. A new non-covalent driven assembly strategy was developed to fabricate chitin-polyphenol-metal hydrogels. The hydrogel showed antibacterial properties and promoted wound healing.
CARBOHYDRATE POLYMERS
(2022)
Review
Pharmacology & Pharmacy
Hui Lv, Hanxiao Liu, Ting Sun, Han Wang, Xiao Zhang, Wei Xu
Summary: A wound occurs when the skin's epidermis and dermis are damaged internally and externally. The traditional method of wound healing is unsatisfactory, causing extended treatment time and increased cost for patients. Therefore, there is an urgent need for a new method to accelerate wound healing. Exosome derived from stem cell (EdSC), a cell-free therapy, offers promising possibilities for wound healing by participating in various stages of the healing process.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Huifeng Dong, Liangyu Wang, Lin Du, Xing Wang, Qin Li, Xiaoyue Wang, Jie Zhang, Jun Nie, Guiping Ma
Summary: Developing a multifunctional hydrogel dressing that can adapt to complex and changeable environments, reconstruct skin sensory functions, and provide continuous bactericidal activity is challenging. In this study, a hydrogel dressing based on alginate and polycation was developed, which showed excellent antibacterial properties and accelerated wound healing in a rat model. The hydrogel also demonstrated multiple response modes for strain, pressure, and temperature sensing, providing a smart solution for wound healing and human health monitoring.
Article
Nanoscience & Nanotechnology
Siyao Cheng, Hao Wang, Xihao Pan, Cheng Zhang, Kexin Zhang, Zelin Chen, Wei Dong, Aming Xie, Xiaoliang Qi
Summary: This study developed a new efficient synthetic strategy to prepare cationic hydrogels (PHCI) with intrinsic antimicrobial properties. In vivo experiments confirmed that the PHCI hydrogel can promote wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Wenhao Pan, Xiaoliang Qi, Yajing Xiang, Shengye You, Erya Cai, Teng Gao, Xianqin Tong, Rongdang Hu, Jianliang Shen, Hui Deng
Summary: This study successfully constructed a hydrogel dressing with excellent ROS scavenging and antibacterial properties, which can promote wound healing and improve the therapeutic effects of skin defect models in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Jing Ren, Miao Wu, Kaiwu Dong, Min Zhang, Ya Cheng, Guoyue Shi
Summary: This article introduces microfluidic chips with centimeter-level 3D channels fabricated by femtosecond laser micromachining, which were used to develop a time-saving, economical and hazardless flow synthesis process. The advantages of this 3D microfluidic chip-based flow synthesis technology were demonstrated through the in situ formation of aryldiazonium salts and subsequent borylation reactions. These advantages include the alteration of reaction temperature to room temperature, a 10-fold reduction in residence time, and improved yields compared to traditional batch processes. It is envisioned that a novel, simplified flow synthetic protocol will be developed towards green organic synthesis via microfluidic chips.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Zaigang Zhou, Yu Liu, Xin Jiang, Chunjuan Zheng, Wenjuan Luo, Xinli Xiang, Xiaoliang Qi, Jianliang Shen
Summary: Recently, it was discovered that the highly expressed PD-L1 in tumor cells significantly impairs the DNA damage induced by Cis-Pt chemotherapy. Additionally, severe side effects of Cis-Pt, such as enhanced drug efflux caused by MDR-1 and increased tumor metastasis, limit its efficacy. However, a new finding shows that Ch-Met has selective mitochondria accumulation capacity, disrupting mitochondrial function and effectively inhibiting upregulated PD-L1 expression, DNA damage repair, drug efflux, and tumor metastasis. This suggests that Ch-Met can enhance the chemotherapy efficacy of Cis-Pt.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Junqing He, Junyan Wang, Min Zhang, Guoyue Shi
Summary: As a folate antagonist, methotrexate (MTX) has been widely used in clinics for treating various tumors and inflammatory diseases. However, the dosage and clearance of MTX vary between individuals, and it may cause life-threatening side effects at high doses. Therefore, a convenient and simple method for MTX sensing is highly demanded.
Article
Engineering, Environmental
Renyong Geng, Jun Wang, Zhen Zhang, Qiujing Dong, Fufang Wu, Shuisheng Chen, Ting Su, Xiaoliang Qi
Summary: This study explored the potential of polydopamine-modified salecan hydrogel (PMSH) for removing antibiotics from water. The addition of polydopamine improved the physical properties of PMSH and enhanced its antibiotic adsorption capacity. PMSH3 demonstrated fast adsorption kinetics and high adsorption capacities for chlorhexidine acetate, minocycline, and erythrocin. The adsorption process was found to be chemical, and the adsorption of antibiotics on PMSH3 was multilayer. The regenerated antibiotics showed strong antimicrobial properties against Staphylococcus aureus and Escherichia coli.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Yajing Xiang, Xiaoliang Qi, Erya Cai, Chaofan Zhang, Jiajia Wang, Yulong Lan, Hui Deng, Jianliang Shen, Rongdang Hu
Summary: A hydrogel (GCM) wound dressing loaded with melanin nanoparticles in a polysaccharide matrix has been developed for efficient healing of bacterially infected diabetic wounds. The GCM hydrogel can rapidly stop bleeding, neutralize inflammatory cytokines, and promote the transition from inflammation to wound healing. It also enhances cell proliferation, migration, and angiogenesis, making it a potential treatment option for various bacteria-infected diabetic wounds.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Reef Einoch Amor, Jeremy Levy, Yoav Y. Broza, Reinis Vangravs, Shelley Rapoport, Min Zhang, Weiwei Wu, Marcis Leja, Joachim A. Behar, Hossam Haick
Summary: Liquid biopsy has the potential to be a useful tool for cancer screening and monitoring. This study demonstrates a method to perform liquid biopsy without physically filtering or isolating cancer cells. By detecting and classifying VOCs emitted from cancer cells in blood or urine samples, accurate detection and classification of cancer can be achieved.
Article
Chemistry, Multidisciplinary
Qiwen Peng, Qiankun Zeng, Fangbing Wang, Xiaoyuan Wu, Runxi Zhang, Guoyue Shi, Min Zhang
Summary: In this study, an integrated sensor for monitoring ONOO- was developed, which demonstrated high sensitivity and selectivity. Using this sensor, the researchers successfully tracked the levels of ONOO- in the brain tissue of AD transgenic mice at early stages and explored the role of ONOO- in the occurrence and development of AD.
Article
Chemistry, Multidisciplinary
Xiaoliang Qi, Erya Cai, Yajing Xiang, Chaofan Zhang, XinXin Ge, Jiajia Wang, Yulong Lan, Hangbin Xu, Rongdang Hu, Jianliang Shen
Summary: This study proposes a novel approach using an immunomodulatory hydrogel to regulate the diabetic microenvironment and achieve self-cascade glucose depletion and ROS scavenging for treating diabetic foot ulcers (DFUs).
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Ruixuan Hu, Xiaolong Li, Jian Xu, Ya Cheng, Min Zhang, Guoyue Shi
Summary: In this study, a three-dimensional microfluidic chip was fabricated using ultrafast laser-processing technology for the continuous synthesis of semiconducting polymer nanoparticles (SPNs) with tunable size. The efficient mixing and powerful vortices of the chip ensured a homogeneous distribution of SPNs and prevented aggregation during synthesis. The integrated high-performance fluorescence of SPNs and the 3D microfluidic chip enabled the development of an online sensing platform for ratiometric fluorescence assays, achieving low limits of detection for H2O2 and glucose. This platform offers new opportunities for facile nanoparticle production and online sensing of biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Lei Lin, Liming Xu, Weijie Sun, Lili Liang, Xiaoliang Qi, Yun-e Zhao
Summary: This study demonstrates that mild photothermal effect can regulate the proliferation and migration of lens epithelial cells (LEC) through cytoskeletal remodeling, and the experiments in vivo show promising results for preventing posterior capsule opacification (PCO).
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Chen Su, Mingyu Li, Yongfeng Zhang, Tianqing Liu, Cong Ren, Peipei Li, Xiaoqiang Yin, Lu Zhang, Min Zhang, Weiwei Wu
Summary: In this study, a hierarchical CuO/Co3O4 nanowire heterostructure was synthesized using a feasible hydrothermal technique, and a high-performance gas sensor with strong response to ethylene glycol was developed.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Yifan Lu, Wenbang Yu, Guoyue Shi, Min Zhang
Summary: In this study, low-consuming carbon quantum dots were synthesized at room temperature to develop a label-free fluorescent sensor array for metal ion discrimination. The sensors can achieve large-scale detection of metal ions and discriminate between different metal ion concentrations and mixtures by utilizing buffers with various pH levels.
