Article
Biochemistry & Molecular Biology
Andrej Kovacik, Petra Pullmannova, Lukas Opalka, Michaela Silarova, Jaroslav Maixner, Katerina Vavrova
Summary: The study shows that different types of ceramides play distinct roles in the structural organization and function of the skin lipid barrier, with their effects on lipid models varying depending on the sphingoid base chain and configuration at the alpha-carbon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Aneta Vovesna, Alexander Zhigunov, Martin Balouch, Jarmila Zbytovska
Summary: The study indicated that stable liposomal systems containing ceramides and other skin barrier lipids are effective in repairing a disrupted skin barrier, and non-homogenized liposomes are more effective than their homogenized counterparts.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Jiun-Wen Guo, Shiou-Hwa Jee
Summary: The treatment of inflammatory skin diseases poses challenges, with topical therapy being the first line of management. The key to success lies in the effectiveness and adaptability of the pharmaceutical formulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jee-hyun Hwang, Haengdueng Jeong, Nahyun Lee, Sumin Hur, Nakyum Lee, Jeong Jun Han, Hye Won Jang, Wang Keun Choi, Ki Taek Nam, Kyung-Min Lim
Summary: The study found that the ex vivo live full-thickness porcine skin model is an excellent alternative to animal experiments for research on the safety and efficacy of cosmetic ingredients. Lactobionic acid showed the best improvement in skin barrier function, and the model could measure TEWL, confirming the significant skin barrier-protective effects of PHAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Yao Chen, Mingrui Liao, Kun Ma, Zi Wang, Bruno Deme, Jeff Penfold, Jian R. Lu, John R. P. Webster, Peixun Li
Summary: This study investigated how surfactants interact with a lipid SC model using neutron diffraction and MD simulations, revealing the impact of surfactant molecular architecture on their interaction. It demonstrated that surfactants can enhance membrane hydration and reduce phase separated crystalline cholesterol, depending on the surfactant chain length, branching, and double bond, providing useful guidance for selecting or designing surfactants for transdermal applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Charlotte M. Beddoes, Denise E. Rensen, Gert S. Gooris, Marc Malfois, Joke A. Bouwstra
Summary: The study found that the effects of FFA chain lengths on lamellar phases and lateral packing vary, with a threshold for water permeability at FFA C16.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Alexander A. Merleev, Stephanie T. Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Alina Marusina, Steven M. Watkins, Forum Patel, Allison C. Billi, Julie Wiedemann, Yoshihiro Izumiya, Ashish Kumar, Ranjitha Uppala, J. Michelle Kahlenberg, Fu-Tong Liu, Iannis E. Adamopoulos, Elizabeth A. Wang, Chelsea Ma, Michelle Y. Cheng, Halani Xiong, Amanda Kirane, Guillaume Luxardi, Bogi Andersen, Lam C. Tsoi, Carlito B. Lebrilla, Johann E. Gudjonsson, Emanual Maverakis
Summary: This study characterized the biogeographic alterations of human epidermal lipids across different body sites and compared the gene expression of keratinocytes. The findings highlight the unique adaptation of the epidermis to environmental insults and the impact of inflammation-associated gene expression changes on the epidermal lipidome.
Review
Dermatology
Lars Norlen, Magnus Lundborg, Christian Wennberg, Ali Narangifard, Bertil Daneholt
Summary: The skin's barrier, composed of a lipid structure in the stratum corneum, plays a crucial role in protecting the body from the environment. Recent advancements in cryo-EM have allowed for a better understanding of the architecture and formation process of this barrier.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Chemistry, Analytical
Joudi Bakar, Rime Michael-Jubeli, Rindala El Khoury, Sabrina Hamla, Ali Assi, Arlette Baillet-Guffroy, Ali Tfayli
Summary: This study aimed to characterize the molecular and functional features of reconstructed human epidermis models using various techniques, focusing on the barrier function, structure, and lipid composition changes during keratinocyte differentiation. The results highlighted the decrease in caffeine penetration, increase in stratum corneum thickness, lipid organization evolution, and ceramide changes throughout the differentiation process. Different behaviors of ceramide subclasses were observed, with a shift between lipid generation and organization identified. Three maturation groups were described based on analytical data, providing insights into the barrier function at different stages of differentiation.
Article
Pharmacology & Pharmacy
Arya Kadukkattil Ramanunny, Sheetu Wadhwa, Monica Gulati, Sachin Kumar Singh, Bhupinder Kapoor, Harish Dureja, Dinesh Kumar Chellappan, Krishnan Anand, Kamal Dua, Rubiya Khursheed, Ankit Awasthi, Rajan Kumar, Jaskiran Kaur, Leander Corrie, Narendra Kumar Pandey
Summary: Skin diseases are a significant burden on the global economy and affect patients' quality of life. Traditional treatment approaches face limitations, but nanomedicine offers efficient targeted drug delivery solutions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Dermatology
Qian Jiao, Lizhi Yue, Leilei Zhi, Yufeng Qi, Jie Yang, Cheng Zhou, Yan Jia
Summary: This paper reviews the structure, function, and influencing factors of the stratum corneum, as well as common skin diseases and solutions. The information provided is important for understanding the metabolism of the stratum corneum and for the management of its health and cosmetic research and development.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Parashara Shamaprasad, Chloe O. Frame, Timothy C. Moore, Alexander Yang, Christopher R. Iacovella, Joke A. Bouwstra, Annette L. Bunge, Clare McCabe
Summary: The skin's outermost layer, the stratum corneum (SC), plays a crucial role in acting as a barrier against water and chemicals. The lipid composition of the SC, consisting of ceramides, cholesterol, and free fatty acids, contributes to its protective function. Molecular simulation has emerged as a valuable tool for studying SC lipid systems and this review aims to provide insights and guidance for both experimentalists and simulation experts in the field. It critically examines the methodology and results of atomistic and coarse-grained models.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Multidisciplinary Sciences
Daniela Kovacs, Emanuela Bastonini, Stefania Briganti, Monica Ottaviani, Andrea D'Arino, Mauro Truglio, Lorenzo Sciuto, Marco Zaccarini, Alessia Pacifico, Carlo Cota, Paolo Iacovelli, Mauro Picardo
Summary: Vitiligo is a skin depigmentation disease caused by multiple mechanisms, with abnormalities in cells and lipids, and inflammatory mediators secreted by keratinocytes may activate immune responses.
Article
Multidisciplinary Sciences
Hye-Jin Ahn, Hae Jin Kim, Hyein Ham, Ji Hwoon Baek, Young Lee, Mahin Alamgir, Babar Rao, Min Kyung Shin
Summary: Objective assessments to evaluate sensitive skin do not well correlate with symptoms. Reflectance confocal microscopy (RCM) was used to compare transepidermal application of zinc in sensitive and non-sensitive skin, showing deeper and higher zinc reflectance in sensitive skin with visualized structural differences. RCM is suggested as a useful tool for evaluating skin barrier integrity.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
L. Ye, Z. Wang, Y. Kim, P. M. Elias, T. Li, S. Wen, J. Song, C. Lv, B. Yang, M-Q Man
Summary: This study conducted a randomized, open-label pilot trial in two cities in northern China to assess whether improvements in epidermal function can mitigate the progression of cognitive impairment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arnout Mieremet, Richard Helder, Andreea Nadaban, Gert Gooris, Walter Boiten, Abdoelwaheb El Ghalbzouri, Joke A. Bouwstra
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Richard W. J. Helder, Jannik Rousel, Walter A. Boiten, Gerrit S. Gooris, Andreea Nadaban, Abdoelwaheb El Ghalbzouri, Joke A. Bouwstra
Summary: Full thickness models (FTM) closely resemble native human skin (NHS) but have reduced barrier function due to deviations in lipid composition, particularly an increase in monounsaturated lipids. In this study, inhibiting stearoyl-CoA desaturase-1 (SCD-1) successfully improved lipid composition in FTMs, leading to better mimicry of NHS lipid composition. This approach may help optimize FTMs for future studies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Arnout Mieremet, Richard W. J. Helder, Andreea Nadaban, Walter A. Boiten, Gert S. Gooris, Abdoelwaheb El Ghalbzouri, Joke A. Bouwstra
Summary: The study focused on optimizing full-thickness models by combining chitosan, lowering oxygen levels, and inhibiting LXR, resulting in improved epidermal morphogenesis, enhanced lipid composition, and better skin barrier functionality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Benedetta Petracca, Andreea Nadaban, Marc Eeman, Gert S. Gooris, Joke A. Bouwstra
Summary: The stratum corneum serves as the main barrier of the skin and consists of keratin-rich dead cells and lipid regions, with lipid classes including ceramides, free fatty acids, and cholesterol. Studies have shown that exposure to ozone can induce chemical modifications in ceramides and cholesterol, impacting lipid organization in the skin barrier but unexpectedly improving barrier function.
CHEMISTRY AND PHYSICS OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Andreea Nadaban, Gerrit S. Gooris, Charlotte M. Beddoes, Robert M. Dalgliesh, Joke A. Bouwstra
Summary: Understanding the lipid arrangement in the skin's outermost layer is crucial for studying the skin barrier function. This study investigated the position of two ceramides in a lamellar phase structure and found that their acyl chains were linearly arranged.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Dermatology
Richard W. J. Helder, Jannik Rousel, Walter A. Boiten, Gerrit S. Gooris, Andreea Nadaban, Abdoelwaheb El Ghalbzouri, Joke A. Bouwstra
Summary: Human skin equivalents (HSEs) are 3D-cultured human skin models that closely resemble native human skin (NHS), but have impaired lipid composition in the stratum corneum (SC). The altered lipid composition is characterized by a high level of monounsaturation, which is primarily influenced by the enzyme stearoyl-CoA desaturase-1 (SCD1). This study aimed to normalize the lipid composition by targeting the peroxisome proliferating activating receptors (PPARs), specifically PPAR-alpha, PPAR-delta, and PPAR-gamma isoforms, as well as the PPAR-alpha agonist Wy14643. However, while downstream targets were activated, minimal impact was observed on the lipid composition after PPAR isoform (de)activation.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andreea Nadaban, Jannik Rousel, Dounia El Yachioui, Gerrit S. Gooris, Charlotte M. Beddoes, Robert M. Dalgliesh, Marc Malfois, Robert Rissmann, Joke A. Bouwstra
Summary: The lipids in the uppermost layer of the skin, the stratum corneum (SC), play a vital role in the skin barrier function. Inflammatory skin diseases alter the composition of these lipids, particularly the molar ratio between CER NS and CER NP, which is associated with impaired skin barrier function. This study investigated the impact of varying the CER NS:CER NP ratios on lipid organization, lipid arrangement, and barrier functionality in SC lipid model systems.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Dermatology
Jannik Rousel, Andreea Nadaban, Mahdi Saghari, Lisa Pagan, Ahnjili Zhuparris, Bart Theelen, Tom Gambrah, Hein E. C. van Der Wall, Rob J. Vreeken, Gary L. Feiss, Tessa Niemeyer-van der Kolk, Jacobus Burggraaf, Martijn B. A. van Doorn, Joke A. Bouwstra, Robert Rissmann
Summary: Seborrheic dermatitis is a chronic inflammatory skin disease characterized by skin barrier dysfunction and changes in ceramide composition. This study found a correlation between barrier impairment and inflammation in seborrheic dermatitis, suggesting that restoring the cutaneous barrier could be a potential therapeutic approach.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jannik Rousel, Mahdi Saghari, Lisa Pagan, Andreea Nadaban, Tom Gambrah, Bart Theelen, Marieke L. de Kam, Jorine Haakman, Hein E. C. van der Wall, Gary L. Feiss, Tessa Niemeyer-van der Kolk, Jacobus Burggraaf, Joke A. Bouwstra, Robert Rissmann, Martijn B. A. van Doorn
Summary: This study evaluated the effectiveness of omiganan in the treatment of facial seborrheic dermatitis. The results showed that omiganan did not significantly improve clinical symptoms or other biomarkers. In contrast, ketoconazole significantly reduced disease severity and had positive effects on Malassezia abundances, microbial diversity, and skin barrier function. The importance of evaluating omiganan in the treatment of facial seborrheic dermatitis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Daphne E. C. Boer, Mina Mirzaian, Maria J. Ferraz, Andreea Nadaban, Anne Schreuder, Alain Hovnanian, Jeroen van Smeden, Joke A. Bouwstra, Johannes M. F. G. Aerts
CLINICA CHIMICA ACTA
(2020)
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)