Article
Chemistry, Applied
Yuanping Hao, Wenwen Zhao, Hao Zhang, Weiping Zheng, Qihui Zhou
Summary: The BP/CS-bFGF hydrogel dressing prepared in this study shows great potential for diabetic chronic wound management. It has strong wet-tissue adhesion, self-mending, and antibacterial properties, and displays fast hemostasis capacity. The hydrogel dressing significantly accelerates full-thickness diabetic wound repair by increasing the production of Ki67, promoting the generation of epithelialization and collagen, inducing the formation of hair follicles, and enhancing neovascularization.
CARBOHYDRATE POLYMERS
(2022)
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Nanoscience & Nanotechnology
Rong Zhang, Yongchang Tian, Long Pang, Taimin Xu, Bing Yu, Hailin Cong, Youqing Shen
Summary: In this study, a wound microenvironment-responsive hydrogel drug-loading system was developed to promote wound healing by releasing basic fibroblast growth factor. This research is of great significance for expanding the application of growth factors in the field of wound care.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Saebin Lim, Ji An Kim, Yoon Hong Chun, Hyun Jong Lee
Summary: This study developed a light-responsive hydrogel-based drug delivery system for controlled release of EGF in wound healing. The results indicate that this system enables precise temporal release of EGF, enhancing its therapeutic potential. This highlights the importance of incorporating stimulus-responsive functionalities into hydrogel-based drug delivery systems for optimizing the clinical applications of protein drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Canran Wang, Xing Jiang, Han-Jun Kim, Shiming Zhang, Xingwu Zhou, Yi Chen, Haonan Ling, Yumeng Xue, Zhaowei Chen, Moyuan Qu, Li Ren, Jixiang Zhu, Alberto Libanori, Yangzhi Zhu, Heemin Kang, Samad Ahadian, Mehmet R. Dokmeci, Peyman Servati, Ximin He, Zhen Gu, Wujin Sun, Ali Khademhosseini
Summary: A flexible electrical patch (ePatch) made with conductive hydrogel as electrodes was developed to improve wound management. The ePatch showed significant benefits in promoting wound re-epithelization, enhancing angiogenesis, mediating immune response, and preventing infection. In vitro and in vivo studies demonstrated the effectiveness of electrical stimulation in promoting cell proliferation and migration, and in accelerating wound closure.
Article
Biochemistry & Molecular Biology
Kazharskaia Mariia, Muhammad Arif, Jie Shi, Fulai Song, Zhe Chi, Chenguang Liu
Summary: A novel polysaccharide composite hydrogel has been developed in this study through a freeze-dried process, showing improved microstructure and excellent drug release performance. The experimental results suggest that the hydrogel has the potential to enhance wound healing efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Yongzhou Lu, Chuanlong Jia, Chengchen Gong, Han Wang, Qin Xiao, Jinxiao Guo, Dalong Ni, Nan Xu
Summary: Delayed or non-healing wounds have a significant impact on patients' quality of life and pose a financial burden on public health systems worldwide. A hydrogel containing low-valence-state molybdenum nanomaterials has been developed to scavenge reactive oxygen species (ROS) and promote wound healing. In vitro and in vivo studies have shown that this novel Mo hydrogel accelerates wound healing, stimulates angiogenesis, and enhances growth factor expression. Due to the essentiality of molybdenum in all organisms, this Mo hydrogel holds great potential for clinical translation in wound healing applications.
Article
Chemistry, Physical
Seol-Ha Jeong, Younghoon Lee, Min-Gyu Lee, Won Jun Song, Ji-Ung Park, Jeong-Yun Sun
Summary: The wearable ionic triboelectric nanogenerator (iTENG) patch has been introduced as a potential therapy to accelerate wound healing by providing electric potential to impaired tissues. Studies have shown that iTENG patches can promote cell migration, proliferation, and secretion of angiogenic growth factors in both normal human dermal fibroblasts and dermal fibroblasts from diabetes mellitus patients. Additionally, rapid wound closure has been validated in in vivo animal models through electrical stimulation using iTENG patches.
Article
Chemistry, Applied
Rong Yang, Jinjian Huang, Wenjie Zhang, Wenliang Xue, Yungang Jiang, Sicheng Li, Xiuwen Wu, Hong Xu, Jianan Ren, Bo Chi
Summary: Injectable hydrogels with tunable stiffness were developed to regulate fibroblast migration and infiltration. The hydrogel exhibited good biocompatibility, biodegradability, and self-healing property in in vitro studies. Animal experiments demonstrated its ability to promote wound healing by increasing collagen deposition and vascularization.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Applied
Morteza Abazari, Tayebeh Akbari, Mahdiye Hasani, Elham Sharifikolouei, Mohammad Raoufi, Alireza Foroumadi, Mohammad Sharifzadeh, Loghman Firoozpour, Mehdi Khoobi
Summary: This study summarizes the preparation, functionalization, and application of polysaccharide-based hydrogels enriched by herbal extracts for various wound healing applications. The structural, biological, and functional impact of polysaccharides and herbal extracts on the characteristics of hydrogels and different phases of the wound healing process are discussed.
CARBOHYDRATE POLYMERS
(2022)
Article
Biophysics
Ting Wang, Wanwan Yi, Yu Zhang, Hang Wu, Hengwei Fan, Jiulong Zhao, Shige Wang
Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
E. Santhini, R. Parthasarathy, M. Shalini, S. Dhivya, L. Amalorpava Mary, V. Vijaya Padma
Summary: This study investigates the use of RADA 16-I nanohydrogel to deliver growth factor PDGF-BB and destroy biofilm formed by wound-specific pathogens. The results demonstrate the ability of RADA 16-I to form a stable beta-sheet structure and sustainably release the growth factor, promoting angiogenesis and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Proma Bhattacharya, Moumita Kundu, Subhayan Das, Yash Verma, Mahitosh Mandal, Sudarsan Neogi
Summary: This study developed a nanocomposite hydrogel for wound healing by incorporating magnesium oxide nanoparticles, which significantly improved the properties of the hydrogel and demonstrated good biocompatibility and stimulated cell growth.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Instruments & Instrumentation
Majid Salehi, Arian Ehterami, Saeed Farzamfar, Ahmad Vaez, Somayeh Ebrahimi-Barough
Summary: The alginate/naringenin hydrogel developed in this study showed positive effects on wound healing process, with appropriate porosity and biodegradability, as well as no toxicity to cells. In the rat experiment, the hydrogel containing 20% naringenin demonstrated the best wound closure among other groups.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shengbo Li, Xuemei Wang, Jing Chen, Jiahe Guo, Meng Yuan, Gui Wan, Chengqi Yan, Wenqing Li, Hans-Guenther Machens, Yuval Rinkevich, Xiaofan Yang, Heng Song, Zhenbing Chen
Summary: Chronic non-healing diabetic wounds and ulcers are a major challenge in the medical field. In this study, a hydrogel with pro-angiogenesis and antibacterial properties was developed, showing potential clinical application in refractory wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
