Review
Chemistry, Applied
Bing-De Zheng, Mei-Tian Xiao
Summary: Polysaccharide-based hydrogel has great potential in biomedical fields, especially in wound healing, due to its excellent biochemical function, abundant sources, and good biocompatibility. Photothermal therapy (PTT) has shown promise in preventing wound infection and promoting wound healing due to its high specificity and low invasiveness. By combining polysaccharide-based hydrogel with PTT, multifunctional hydrogels with photothermal, bactericidal, anti-inflammatory, and tissue regeneration properties can be designed for better therapeutic effects.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Samia Zahoor, Hafiz Muhammad Tahir, Shaukat Ali, Aamir Ali, Ayesha Muzamil, Zainab Murtaza, Nimbra Zahoor
Summary: This study prepared hydrogels based on silk sericin and plant extracts for the treatment of diabetic wounds. The hydrogels showed significantly higher wound contraction and improved levels of anti-inflammatory cytokines and tissue inhibitor metalloproteinase compared to the control group. The hydrogel with 4% sericin, 4% banyan, and 4% onion showed the best results.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Aaliya Ali, Prakrati Garg, Rohit Goyal, Gurjot Kaur, Xiangkai Li, Poonam Negi, Martin Valis, Kamil Kuca, Saurabh Kulshrestha
Summary: The study evaluated the wound healing efficacy of n-hexane extract and hydrogels of Moringa oleifera seeds, demonstrating their significant effectiveness in wound healing.
Article
Nanoscience & Nanotechnology
Xia Qiu, Jiamin Zhang, Lilong Cao, Qin Jiao, Junhao Zhou, Lijun Yang, Hong Zhang, Yuping Wei
Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Jia Wan, Yongzhi Liang, Xiaofeng Wei, Haiyi Liang, Xu-Lin Chen
Summary: Skin injuries are a common clinical trauma worldwide and wound dressings play a crucial role in wound healing. Natural polymer-based hydrogels are considered ideal materials for new generation dressings due to their biocompatibility and wetting ability. However, their mechanical properties and wound healing efficacy are limited. This study developed a double network hydrogel based on natural chitosan molecules to enhance mechanical properties, and loaded emodin to improve the healing effect of the dressing. The chitosan-emodin network structure endowed the hydrogel with excellent mechanical properties and the loaded emodin showed excellent wound healing properties, promoting cell proliferation, migration, and secretion of growth factors, and facilitating blood vessel and collagen regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zongyao Li, Jia Man, Xiaojie Wang, Yongqi Zhang
Summary: The hydrogel wound dressings prepared in this study, containing herbal extracts, have good biocompatibility and moisture retention. They can promote coagulation, inhibit bacterial growth, and possess antioxidant properties, showing great potential for clinical applications.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zhengbo Hu, Kai Zhao, Xingcan Chen, Mingyuan Zhou, Yuchi Chen, Xiaoqing Ye, Fangmei Zhou, Zhishan Ding, Bingqi Zhu
Summary: The developed BSP/BER hydrogel exhibited excellent biocompatibility and remarkable antibacterial, anti-inflammatory, and antioxidant properties. Animal experiments demonstrated that the hydrogel significantly accelerated wound healing in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Applied
Bing-De Zheng, Jing Ye, Yu-Cheng Yang, Ya -Yan Huang, Mei-Tian Xiao
Summary: Hydrogels have advantages such as injectability and self-healing, which play an important role in promoting wound healing and inhibiting bacterial growth.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Qi Zhang, Miao Zhang, Teng Wang, Xiangyan Chen, Quancai Li, Xia Zhao
Summary: Maintaining a moist and sterile environment is beneficial for wound healing. A novel natural multifunctional hydrogel, combining Aloe polysaccharide (AP) and honey, was prepared for infected wound healing. The hydrogel exhibited good water retention capacity, antibacterial activity, and accelerated the healing of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Nahideh Asadi, Hamidreza Pazoki-Toroudi, Azizeh Rahmani Del Bakhshayesh, Abolfazl Akbarzadeh, Soodabeh Davaran, Nasim Annabi
Summary: Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix and ability to provide a moist environment. However, lack of multifunctionality and low mechanical properties may limit their ability to support skin tissue regeneration. Incorporating various biomaterials and nanostructures is an emerging approach to develop multifunctional hydrogels for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Hengji Zhao, Yushu Zhang, Chao Zhou, Chunling Zhang, Bo Liu
Summary: Natural polysaccharide-based hydrogels provide effective skin protection during trauma and exhibit good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Maarten A. Mees, Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, Anja Vananroye, Erin Koos, Stelios Alexandris, Sabine Rosenfeldt, Samuel Eyley, Joachim Koetz, Geert van Loo, Wim Thielemans, Esther Hoste
Summary: High-mobility group box 1 (HMGB1) released during wounding delays skin regeneration. We discovered that dissolving glycyrrhizin in water forms a hydrogel with remarkable rheological properties. Glycyrrhizin-based hydrogels accelerate the closure of cutaneous wounds in normoglycemic and diabetic mice by influencing keratinocyte migration.
Article
Chemistry, Applied
Yongyan Yang, Lifeng Xu, Jingfei Wang, Qingye Meng, Shuangling Zhong, Yan Gao, Xuejun Cui
Summary: Hydrogels are polymer materials with three-dimensional networks that can absorb a large amount of water and biological fluids. Self-healing hydrogels, due to their good biocompatibility and biodegradability, have great potential applications in tissue engineering, wound dressings, drug delivery, and other fields.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Ziqiang Zhou, Xuejuan Zhang, Lijun Xu, Huangjie Lu, Yuying Chen, Chuanbin Wu, Ping Hu
Summary: In this study, a novel hydrogel was designed as a wound dressing material for diabetic wounds. The hydrogel showed good biocompatibility and enhanced wound healing in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Jing Wang, Tianyi Dai, Yankun Lin, Hongbing Jia, Qingmin Ji, Guoliang Yuan
Summary: In this study, intelligent ionic hydrogels based on oxide sodium alginate, poly (acrylamide-co-acrylic acid), and FeCl3 were synthesized. The hydrogels showed excellent elongation at break, strong tensile strength, and high self-healing efficiency. They also demonstrated accurate and stable detection of human movement and physiological stimuli.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Materials Science, Biomaterials
Zahra Mousivand, Hossein Ayazi, Alieh Abdollahi, Hamid Akbari, Mohammad Raoufi, Elham Sharifikolouei
Summary: This research focuses on the fabrication of scaffolds using PLLA and PEO polymers loaded with active substances Argireline and Dexpanthenol. The electrospun nanofiber scaffolds are analyzed for their properties and tested on rat models with second-degree burns. The results demonstrate that the use of both active substances leads to a significant reduction in wound area and improved histological features such as angiogenesis and collagen formation.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Biology
Masoomeh Fooladi, Alireza Shirazi, Peyman Sheikhzadeh, Mahsa Amirrashedi, Fatemeh Ghahramani, Mohsen Cheki, Mehdi Khoobi
Summary: This study investigated the efficacy of telmisartan in the recovery process of intestinal tissue after in vivo irradiation using F-18-FDG microPET imaging. The results showed that telmisartan effectively attenuated radiation-induced injury in the intestine, which was consistent with histological analysis.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Polymer Science
Farzaneh Sorouri, Pegah Azimzadeh Asiabi, Parastoo Hosseini, Ali Ramazani, Sahar Kiani, Tayebeh Akbari, Mohammad Sharifzadeh, Marzieh Shakoori, Alireza Foroumadi, Loghman Firoozpour, Mohsen Amin, Mehdi Khoobi
Summary: This study introduces a simple strategy for preparing a multifunctional dressing for burn wound treatment using carnosine-enriched bentonite loaded into Carbopol gel. The results suggest that the Carb-CEB gel has improved physicochemical properties and antioxidant activity, leading to accelerated wound healing, tissue repair, and angiogenesis.
Article
Biochemical Research Methods
Zahra Saffari, Mina Sepahi, Reza Ahangari-Cohan, Mehdi Khoobi, Mojtaba Hamidi-Fard, Amir Ghavidel, Mohammad Reza Aghasadeghi, Dariush Norouzian
Summary: A QCM biosensor was developed for the label-free detection of HBsAg. The biosensor showed excellent detection performance with a wide dynamic range, high sensitivity, and selectivity, comparable with ELISA. It can detect HBsAg in human sera and has the advantages of regeneration ability and low cost.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Materials Science, Paper & Wood
Moones Rahmandoust, Elham Sharifikolouei, Alice Lassnig, Sepideh Zoghi
Summary: Paper-based analytical devices are a promising choice for lab-on-chip and biodetection applications. Carbon quantum dots (CQDs) are well-known for their stable photoluminescence properties and cost-effective synthesis techniques. However, the durability and sustainability of CQDs as fluorescent composites have not been systematically studied. In this investigation, the photoluminescence emission intensity of cellulose papers containing different types of CQDs was studied over two months, with varying storage temperatures and pH values. The results showed that both environmental conditions and chemical structure of the embedded CQDs significantly affected the durability and sustainability of the sensors. The fluorescent composites exhibited high performance, with PL emission intensities sustained at 60-90% over time.
Article
Materials Science, Characterization & Testing
Tayebeh Modiri-Delshad, Ali Ramazani, Mehdi Khoobi, Hamid Akbari Javar, Tayebeh Akbari, Mohsen Amin
Summary: Development of novel antimicrobial nanofibrous mats containing phytochemicals is a promising strategy to combat antibiotic resistance in wound healing. This study successfully fabricated electrospun chitosan/polycaprolactone (CS/PCL) nanofiber mats loaded with Morinda communis leaf extract (MCLE) at different concentrations. The physicochemical properties of the nanofiber mats were evaluated using various characterization techniques, and the results showed that the incorporation of MCLE enhanced the antimicrobial activity and hydrophilicity of the mats. The manufactured nanofiber mats demonstrated significant reduction in bacterial count and could be a promising option for wound dressing.
POLYMERS & POLYMER COMPOSITES
(2023)
Article
Engineering, Environmental
Francesco Barracco, Francesca Demichelis, Elham Sharifikolouei, Monica Ferraris, Debora Fino, Tonia Tommasi
Summary: The production of municipal solid waste (MSW) has increased significantly in recent years. Incineration of MSW can reduce its volume and recover energy, but it also leads to the generation of hazardous residues. This study proposes the valorization of vitrified fly ash (FA) through the production of porous glass-ceramics. Life Cycle Assessment (LCA) was used to evaluate the entire process, from incineration to glass-ceramics production. The results indicate that using bottom ashes as a silica source and combining methane combustion-aided recovery is the most environmentally sustainable scenario.
Article
Oncology
Sogol Saberi, Tayebeh Modiri-Delshad, Shahroo Etemad-Moghadam, Mojgan Alaeddini, Rahele Jamshidloo, Ali Ramazani, Hadiseh Mohammadpour, Reem Hanna, Mehdi Khoobi, Sima Shahabi
Summary: Photodynamic therapy (PDT) is a valuable option for cancer treatment, and natural photosensitizers can enhance its efficacy. In this study, a cubic form of spirulina platensis (SP) was synthesized and compared with naturally-occurring microhelical SP (MSP) and phycocyanin (Pc) in anticancer-PDT. The results showed that both SPs were safe and efficient, while caution should be exercised when using Pc.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Environmental Sciences
Nesa Hamidian, Gholamreza Dehghan, Samaneh Rashtbari, Alireza Khataee, Mehdi Khoobi, Nader Sheibani
Summary: A magnetite/Gd3+/beta-cyclodextrin nanoplatform was prepared and used for the degradation of tetracycline. The nanoplatform showed higher peroxidase-mimic activity than natural enzymes. It was able to degrade tetracycline efficiently and could be reused.
Article
Nanoscience & Nanotechnology
Elham Sharifikolouei, Antoni Zywczak, Baran Sarac, Tomasz Koziel, Reza Rashidi, Piotr Bala, Michela Fracasso, Roberto Gerbaldo, Gianluca Ghigo, Laura Gozzelino, Daniele Torsello
Summary: In this study, Fi(40)Ni(40)B(20) metallic glass microfibers with a diameter of 5 μm were fabricated, and the influence of different melt-spinning wheel velocities on their structure and magnetic properties was investigated. Cylindrical magnetic field shields with anisotropic static field shielding behavior were obtained by wrapping the microfibers around a cast. Moreover, embedding the microfibers in an epoxy matrix significantly improved the electromagnetic properties of the composite at GHz frequencies.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Farzaneh Sorouri, Parastoo Hosseini, Mohammad Sharifzadeh, Sahar Kiani, Mehdi Khoobi
Summary: In this study, a multifunctional injectable hydrogel with antioxidant, neuroprotective, and neuroregenerative effects was designed. The hydrogel showed promising results in inhibiting glial scar progression, reducing inflammation, promoting angiogenesis, and inducing myelinated axon regeneration in a rat spinal cord injury model, leading to a significant improvement in motor performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Amir Rezvan, Elham Sharifikolouei, Viktor Soprunyuk, Wilfried Schranz, Juraj Todt, Alice Lassnig, Christoph Gammer, Nikolaus August Sifferlinger, Atacan Asci, Ilya Okulov, Sandra Schlogl, Jozef Keckes, Ziba Najmi, Andrea Cochis, Alessandro Calogero Scalia, Lia Rimondini, Baran Sarac, Juergen Eckert
Summary: The application of highly biocompatible advanced materials leads to fewer complications and more successful medical treatments. This study proposes a new type of metallic glass that can be used as an oral implant material, and it explores the processing methods to improve its specific properties. The results show that the processed material has higher thermomechanical stability and better cytocompatibility.
MATERIALS & DESIGN
(2023)
Article
Multidisciplinary Sciences
Farzaneh Sorouri, Elham Gholibegloo, Tohid Mortezazadeh, Sahar Kiani, Alireza Foroumadi, Loghman Firoozpour, Mehdi Khoobi
Summary: This study introduces a simple method to prepare new MnO2 nanomaterials (MNMs) using tannic acid as a template. The flower-like M1-MnO2 NMs showed biocompatibility and stronger oxidase and peroxidase mimetic activity compared to the near-spherical M2-MnO2. The properties of the synthesized MNMs, such as crystallinity, morphology, pore size, and specific surface area, strongly influenced the signal intensity and r(1) relaxivity in MRI.
SCIENTIFIC REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Elham Sharifikolouei, Tomasz Koziel, Piotr Bala, Antoni Zywczak, Lukasz Gondek, Reza Rashidi, Michela Fracasso, Roberto Gerbaldo, Gianluca Ghigo, Laura Gozzelino, Daniele Torsello
Summary: This article presents a novel method for fabricating EMI shielding materials using cobalt-based metallic glass microfibers. These microfibers exhibit excellent soft magnetic properties and shielding features, making them suitable for effective EMI shielding in complex geometries.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Applied
Maryam Keykhaee, Mahban Rahimifard, Alireza Najafi, Maryam Baeeri, Mohammad Abdollahi, Fatemeh Mottaghitalab, Mehdi Farokhi, Mehdi Khoobi
Summary: The study proposes a novel approach using a multifunctional hydrogel to manage diabetic foot ulcers (DFUs). The hydrogel, made from a combination of alginate and gum arabic, is enhanced with nerve growth factor (NGF) immobilized in specially designed mesoporous silica nanoparticles (MSN). The hydrogel shows sustained release of NGF and significantly improves wound healing. The hydrogel also reduces inflammation, increases angiogenesis, and improves tissue pathology. This newly developed composite system holds promise as a potential treatment for non-healing diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
