Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification

(2012) Hwanhee Oh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

(2011) J-H Ryu et al.   CELL DEATH AND DIFFERENTIATION

Cytokine-like 1 Knock-out Mice (Cytl1−/−) Show Normal Cartilage and Bone Development but Exhibit Augmented Osteoarthritic Cartilage Destruction

(2011) Jimin Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

(2011) Thomas F. Chan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients

(2010) Sittisak Honsawek et al.   BMC MUSCULOSKELETAL DISORDERS

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

(2010) Arjen B. Blom et al.   CURRENT DRUG TARGETS

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with rheumatoid arthritis and knee osteoarthritis

(2009) N Voorzanger-Rousselot et al.   ANNALS OF THE RHEUMATIC DISEASES

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

(2008) P. Bovolenta et al.   JOURNAL OF CELL SCIENCE

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint

(2008) L.-H. Weng et al.   OSTEOARTHRITIS AND CARTILAGE

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology

Molecular network of cartilage homeostasis and osteoarthritis

(2007) Megumi Hashimoto et al.   MEDICINAL RESEARCH REVIEWS