Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?

Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

(2013) K. Nakano et al.   JOURNAL OF IMMUNOLOGY

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

(2013) Yun Liu et al.   NATURE BIOTECHNOLOGY

Mechanisms of DNA methylation and demethylation in mammals

(2012) Ghislain Auclair et al.   BIOCHIMIE

DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival

(2012) Daniel D. De Carvalho et al.   CANCER CELL

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCs

(2012) Ling Ye et al.   Cell Stem Cell

The Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis

(2012) Liv Austenaa et al.   IMMUNITY

Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA

(2012) Derek Baxter et al.   IMMUNOLOGY AND CELL BIOLOGY

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

(2012) Joshua D. Stender et al.   MOLECULAR CELL

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis

(2011) Jelena Vojinovic et al.   ARTHRITIS AND RHEUMATISM

Inflammatory memories: Is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?

(2011) Caroline Ospelt et al.   AUTOIMMUNITY REVIEWS

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

The Therapeutic Potential of Epigenetics in Autoimmune Diseases

(2011) Maria De Santis et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Epigenetic regulation of immune cell functions during post-septic immunosuppression

(2011) William F. Carson et al.   Epigenetics

MicroRNAs in rheumatoid arthritis

(2011) Angela Ceribelli et al.   FEBS LETTERS

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

Epigenetic regulation of osteoclast differentiation: Possible involvement of Jmjd3 in the histone demethylation of Nfatc1

(2011) Tetsuro Yasui et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Interleukin-6 Gene Promoter Methylation in Rheumatoid Arthritis and Chronic Periodontitis

(2011) Kohei Ishida et al.   JOURNAL OF PERIODONTOLOGY

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A polymorphism in the 3’-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility

(2010) Anthoula Chatzikyriakidou et al.   JOINT BONE SPINE

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis

(2010) Wei-Ping Chen et al.   MOLECULAR BIOLOGY REPORTS

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

(2010) Arturas Petronis   NATURE

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Epigenomics reveals a functional genome anatomy and a new approach to common disease

(2010) Andrew P Feinberg   NATURE BIOTECHNOLOGY

Annotating non-coding regions of the genome

(2010) Roger P. Alexander et al.   NATURE REVIEWS GENETICS

CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer

(2010) A Lujambio et al.   ONCOGENE

Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF- B p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells

(2010) Q.-Y. Choo et al.   RHEUMATOLOGY

Histone lysine methylation: an epigenetic modification?

(2010) Neil P Blackledge et al.   Epigenomics

Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome

(2010) Robert S. Illingworth et al.   PLoS Genetics

Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels

(2010) Maja Klug et al.   GENOME BIOLOGY

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Decreased DNA methyltransferase levels contribute to abnormal gene expression in “senescent” CD4+CD28− T cells

(2009) Ying Liu et al.   CLINICAL IMMUNOLOGY

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts

(2009) M. HORIUCHI et al.   JOURNAL OF RHEUMATOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation status of a single CpG site in theIL6promoter is related toIL6messenger RNA levels and rheumatoid arthritis

(2008) Christoper J. Nile et al.   ARTHRITIS AND RHEUMATISM

Dynamic protein methylation in chromatin biology

(2008) S. S. Ng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

(2008) T VAISSIERE et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH