Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Hasan Mehraj, Satoshi Takahashi, Naomi Miyaji, Ayasha Akter, Yutaka Suzuki, Motoaki Seki, Elizabeth S. Dennis, Ryo Fujimoto
Summary: Covalent modifications of histone proteins, such as H3K4me3 and H3K36me3, are found to regulate gene expression in Brassica rapa L. Two lines of this species showed enrichment of these histone marks at transcription start sites, with gene expression levels being influenced by them. Genes with both H3K4me3 and H3K36me3 typically showed constitutive high expression levels. Additionally, bivalent active and repressive histone modifications were observed in some genes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ryan J. Separovich, Mandy W. M. Wong, Tara K. Bartolec, Joshua J. Hamey, Marc R. Wilkins
Summary: This study comprehensively analyzed the phosphoregulation of the histone methylation network in Saccharomyces cerevisiae. The functional investigation revealed the important roles of phosphorylation sites on several enzymes in cellular stress responses.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Oncology
Jayden Sterling, Sharleen V. Menezes, Ramzi H. Abbassi, Lenka Munoz
Summary: Histone lysine demethylases (KDMs) are enzymes that remove methylation marks on lysines in nucleosomes' histone tails, regulating gene transcription and playing important roles in cancer development. KDMs can have activating or repressing effects on gene transcription, regulating the expression of oncogenes and tumor suppressors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Endocrinology & Metabolism
Ye-Chi Cao, Su-Kang Shan, Bei Guo, Chang-Chun Li, Fu-Xing-Zi Li, Ming-Hui Zheng, Qiu-Shuang Xu, Yi Wang, Li-Min Lei, Ke-Xin Tang, Wen-Lu Ou-Yang, Jia-Yue Duan, Yun-Yun Wu, Muhammad Hasnain Ehsan Ullah, Zhi-Ang Zhou, Feng Xu, Xiao Lin, Feng Wu, Xiao-Bo Liao, Ling-Qing Yuan
Summary: Histone methylation modification may play a key role in the development of vascular calcification, which involves various complex pathophysiological processes. Comprehensive research on the role and mechanism of lysine methylation modification in VC is crucial for identifying new therapeutic targets and developing new drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Rodrigo Villasenor, Tuncay Baubec
Summary: Nucleosomes are basic structures used to package genetic information, subject to diverse chemical modifications. These modifications serve as interaction hubs for nuclear proteins, ensuring correct deposition to the genome. The regulation of chromatin marks relies on coordinated activities of writer, eraser, and reader enzymes, often depending on complex multicomponent regulatory circuits.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Tanjing Song, Suli Lv, Neng Li, Xuefeng Zhao, Xianyun Ma, Yingying Yan, Weixia Wang, Lidong Sun
Summary: m6A machinery, a crucial RNA modification mechanism, is involved in the regulation of RNA processing and function. Recent studies have demonstrated that m6A machinery can be recruited to chromatin by various factors, leading to direct regulation of chromatin biology such as transcription, DNA damage repair, and DNA recombination.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Cell Biology
Werner Giehl Glanzner, Mariana Priotto de Macedo, Karina Gutierrez, Vilceu Bordignon
Summary: Animal cloning has been successful in over 20 mammalian species using SCNT, with pigs being the leading species. The importance of pig cloning lies in its relevance to food production and biomedical applications. Despite recognized progress, the overall efficiency of SCNT in pigs remains low. New strategies for chromatin and epigenetic reprogramming may revolutionize pig cloning.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Plant Sciences
Lea Faivre, Daniel Schubert
Summary: Chromatin is important for transcriptional regulation, and the histone modifications H3K4me3 and H3K27me3 are usually described as mutually exclusive activator and repressor. However, recent studies show that these marks can co-exist, forming a distinctive chromatin state called bivalency. The role of bivalency in transcriptional regulation remains unclear, but it is proposed to maintain transcriptional plasticity and prevent irreversible silencing of target genes. This review explores the potential factors involved in bivalency and highlights techniques for further study.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Endocrinology & Metabolism
Lindsay Moritz, Saher Sue Hammoud
Summary: This article explores the molecular mechanisms underlying male fertility and the process of chromatin remodeling. It points out the current gaps in understanding of the chromatin remodeling process and suggests future research directions to enhance our knowledge of the histone-to-protamine exchange and the etiology of idiopathic male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Renata Brito Falcao-Holanda, Brunialti Milena Karina Colo, Miriam Galvonas Jasiulionis, Reinaldo Salomao
Summary: Sepsis is characterized by an initial hyperinflammatory response, followed by a compensatory anti-inflammatory response which can lead to immunosuppression. Epigenetic changes play a central role in the pathogenesis of sepsis, affecting host cells' response to infection and orchestrating the inflammatory response. Epigenetic interventions have the potential to be used in the treatment of sepsis.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Chloe D. Goldsmith, Thomasina Donovan, Nicole Vlahovich, David B. Pyne
Summary: This perspective article discusses how exercise can delay T cell ageing by analyzing the relationship between metabolism and epigenetics, proposing a potential impact of exercise on CD4+ T cell plasticity.
FRONTIERS IN IMMUNOLOGY
(2021)
