RNA Structural Elements of Hepatitis C Virus Controlling Viral RNA Translation and the Implications for Viral Pathogenesis

Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection

(2012) Alessia Ruggieri et al.   Cell Host & Microbe

New advances in the molecular biology of hepatitis C virus infection: towards the identification of new treatment targets

(2012) Alexander Ploss et al.   GUT

Gemin5 proteolysis reveals a novel motif to identify L protease targets

(2012) David Piñeiro et al.   NUCLEIC ACIDS RESEARCH

A twist in the tail: SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication

(2012) Andrew Tuplin et al.   NUCLEIC ACIDS RESEARCH

Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches

(2012) S. M. Dibrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site

(2011) Carl Laxton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The functional RNA domain 5BSL3.2 within the NS5B coding sequence influences hepatitis C virus IRES-mediated translation

(2011) Cristina Romero-López et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

eIF2A mediates translation of hepatitis C viral mRNA under stress conditions

(2011) Joon Hyun Kim et al.   EMBO JOURNAL

Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191)

(2011) Ingrid Imhof et al.   HEPATOLOGY

Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus

(2011) Jean-Michel Pawlotsky   HEPATOLOGY

Ribosome Binding to a 5' Translational Enhancer Is Altered in the Presence of the 3' Untranslated Region in Cap-Independent Translation of Turnip Crinkle Virus

(2011) V. A. Stupina et al.   JOURNAL OF VIROLOGY

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

Hepatocellular carcinoma: insight from animal models

(2011) Yan Li et al.   Nature Reviews Gastroenterology & Hepatology

Viral subversion of the host protein synthesis machinery

(2011) Derek Walsh et al.   NATURE REVIEWS MICROBIOLOGY

Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1

(2011) Sung Mi Park et al.   NUCLEIC ACIDS RESEARCH

miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components

(2011) Ashley P. E. Roberts et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation

(2011) Noemí Fernández et al.   NUCLEIC ACIDS RESEARCH

Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

(2011) D R McGivern et al.   ONCOGENE

An Integrated Transcriptomic and Meta-Analysis of Hepatoma Cells Reveals Factors That Influence Susceptibility to HCV Infection

(2011) Jamie I. MacPherson et al.   PLoS One

Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex

(2011) E. S. Machlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCV IRES domain IIb affects the configuration of coding RNA in the 40S subunit's decoding groove

(2011) M. E. Filbin et al.   RNA

Crystal Structure of the HCV IRES Central Domain Reveals Strategy for Start-Codon Positioning

(2011) Katherine E. Berry et al.   STRUCTURE

Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase

(2010) Shuanghu Liu et al.   ANTIVIRAL RESEARCH

Hepatitis C virus replication cycle

(2010) Ralf Bartenschlager et al.   JOURNAL OF HEPATOLOGY

Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122

(2010) R. K. Jangra et al.   JOURNAL OF VIROLOGY

DDX6 (Rck/p54) Is Required for Efficient Hepatitis C Virus Replication but Not for Internal Ribosome Entry Site-Directed Translation

(2010) R. K. Jangra et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Controls Interferon Production through PKR Activation

(2010) Noëlla Arnaud et al.   PLoS One

Inhibitor-induced structural change in the HCV IRES domain IIa RNA

(2010) R. B. Paulsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tailoring the switch from IRES-dependent to 5'-end-dependent translation with the RNase P ribozyme

(2010) N. Fernandez et al.   RNA

The terminal loop of a 3′ proximal hairpin plays a critical role in replication and the structure of the 3′ region of Turnip crinkle virus

(2010) Xuefeng Yuan et al.   VIROLOGY

Internal translation initiation of picornaviruses and hepatitis C virus

(2009) Michael Niepmann   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Toward a structural understanding of IRES RNA function

(2009) Megan E Filbin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs

(2009) D. M. Landry et al.   GENES & DEVELOPMENT

Inhibition of hepatitis C virus replication and internal ribosome entry site-dependent translation by an RNA molecule

(2009) C. Romero-Lopez et al.   JOURNAL OF GENERAL VIROLOGY

Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA

(2009) Jerod Parsons et al.   Nature Chemical Biology

In vitro characterization of a miR-122-sensitive double-helical switch element in the 5′ region of hepatitis C virus RNA

(2009) Rosa Díaz-Toledano et al.   NUCLEIC ACIDS RESEARCH

Conserved functional domains and a novel tertiary interaction near the pseudoknot drive translational activity of hepatitis C virus and hepatitis C virus-like internal ribosome entry sites

(2009) Laura E. Easton et al.   NUCLEIC ACIDS RESEARCH

Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates

(2009) N. Scheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR

(2009) S. Weinlich et al.   RNA

A long-range RNA-RNA interaction between the 5' and 3' ends of the HCV genome

(2009) C. Romero-Lopez et al.   RNA

Rescue of internal initiation of translation by RNA complementation provides evidence for a distribution of functions between individual IRES domains

(2009) Paula Serrano et al.   VIROLOGY

Genomic Analysis Reveals a Potential Role for Cell Cycle Perturbation in HCV-Mediated Apoptosis of Cultured Hepatocytes

(2009) Kathie-Anne Walters et al.   PLoS Pathogens

Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro

(2008) C ALOTTE et al.   ANTIVIRAL RESEARCH

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

(2008) Catherine L. Jopling et al.   Cell Host & Microbe

microRNA-122 stimulates translation of hepatitis C virus RNA

(2008) Jura Inga Henke et al.   EMBO JOURNAL

Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation

(2008) Francisco Martínez-Azorín et al.   FEBS LETTERS

New insights into internal ribosome entry site elements relevant for viral gene expression

(2008) E. Martinez-Salas et al.   JOURNAL OF GENERAL VIROLOGY

Structural Determinant of Human La Protein Critical for Internal Initiation of Translation of Hepatitis C Virus RNA

(2008) T. Mondal et al.   JOURNAL OF VIROLOGY

Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation

(2008) M. I. Barria et al.   NUCLEIC ACIDS RESEARCH

A novel role for Gemin5 in mRNA translation

(2008) Almudena Pacheco et al.   NUCLEIC ACIDS RESEARCH

Riboproteomic analysis of polypeptides interacting with the internal ribosome-entry site element of foot-and-mouth disease viral RNA

(2008) Almudena Pacheco et al.   PROTEOMICS

The impact of RNA structure on picornavirus IRES activity

(2008) Encarnación Martínez-Salas   TRENDS IN MICROBIOLOGY

Structure and function of HCV IRES domains

(2008) Peter J. Lukavsky   VIRUS RESEARCH

Divergent picornavirus IRES elements

(2008) Graham J. Belsham   VIRUS RESEARCH

Relevance of RNA structure for the activity of picornavirus IRES elements

(2008) Olga Fernández-Miragall et al.   VIRUS RESEARCH

Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes

(2005) Yonghao Yu et al.   PROTEIN SCIENCE