Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms
出版年份 2011 全文链接
标题
Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms
作者
关键词
-
出版物
XENOBIOTICA
Volume 42, Issue 1, Pages 57-74
出版商
Informa UK Limited
发表日期
2011-10-13
DOI
10.3109/00498254.2011.622418
参考文献
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- (2010) NATURE REVIEWS DRUG DISCOVERY
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- (2010) David Hallifax et al. PHARMACEUTICAL RESEARCH
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- (2009) Masoud Jamei et al. AAPS Journal
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- (2009) D. Hallifax et al. CURRENT DRUG METABOLISM
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