Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?

From definition to implementation: a cross-industry perspective of past, current and future MIST strategies

(2011) Angus N.R. Nedderman et al.   XENOBIOTICA

Determination of Exposure Multiples of Human Metabolites for MIST Assessment in Preclinical Safety Species without Using Reference Standards or Radiolabeled Compounds

(2010) Shuguang Ma et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

(2010) H. Gao et al.   DRUG METABOLISM AND DISPOSITION

Use of the Entero-Test, a Novel Approach for the Noninvasive Capture of Biliary Metabolites in Dogs

(2010) W. J. Guiney et al.   DRUG METABOLISM AND DISPOSITION

Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment

(2010) D. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery

(2010) A. Mutlib et al.   DRUG METABOLISM AND DISPOSITION

Validation of Isolated Metabolites from Drug Metabolism Studies as Analytical Standards by Quantitative NMR

(2010) G. S. Walker et al.   DRUG METABOLISM AND DISPOSITION

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

(2010) W. W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Biotransformation Profiling of [14C]Ixabepilone in Human Plasma, Urine and Feces Samples Using Accelerator Mass Spectrometry (AMS)

(2010) S. Nilgün Çömezoğlu et al.   Drug Metabolism and Pharmacokinetics

A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations

(2010) Ping Yi et al.   Bioanalysis

Addressing metabolite safety during first-in-man studies using14C-labeled drug and accelerator mass spectrometry

(2010) Graham Lappin et al.   Bioanalysis

Best practices in a tiered approach to metabolite quantification: views and recommendations of the European Bioanalysis Forum

(2010) Philip Timmerman et al.   Bioanalysis

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

(2009) Laurent Leclercq et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Strategy for the Risk Assessment of Human Genotoxic Metabolites

(2009) Krista L. Dobo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

(2009) Don Walker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting Circulating Human Metabolites: How Good Are We?

(2009) Shelby Anderson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

(2009) Deepak Dalvie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

(2008) Karthick Vishwanathan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

(2008) Robert Espina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cyclic Metabolites: Chemical and Biological Considerations

(2008) John Erve   CURRENT DRUG METABOLISM

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES