Article
Chemistry, Applied
Juanjuan Qin, Min Yang, Yucheng Wang, Wenqiang Wa, Jie Zheng
Summary: The study found that caffeic acid and caffeic acid phenethyl ester form complexes with micellar casein through hydrophobic interactions, with higher thermal stability and DPPH radical scavenging capacity compared to free micellar casein or caffeic acid/caffeic acid phenethyl ester. These complexes do not induce the dissociation of casein micelles.
Review
Food Science & Technology
Sajjad Ehtiati, Mehdi Alizadeh, Faeghe Farhadi, Kimia Khalatbari, Basiru O. Ajiboye, Vafa Baradaran Rahimi, Vahid Reza Askari
Summary: Caffeic acid and caffeic acid phenethyl ester (CAPE) are natural compounds that have shown promising effects against natural and chemical toxins. Their antioxidant, anti-inflammatory, and anti-apoptotic properties contribute to their protective effects. They can protect against a wide range of toxins, including mycotoxins, heavy metals, environmental toxins, pesticides, industrial chemicals, and pharmaceuticals. Their potential makes them candidates for developing novel therapies and functional foods.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Anatomy & Morphology
Paulo Henrique Neves Santos, Hebert Lacerda Silva, Elizabeth Ferreira Martinez, Julio Cesar Joly, Ana Paula Dias Demasi, Larissa Moreira Spinola de Castro Raucci, Lucas Novaes Teixeira
Summary: The study demonstrated that low concentrations of CAPE can positively modulate osteogenesis in vitro, as evidenced by enhanced cell viability, increased alkaline phosphatase activity, promoted matrix mineralization, and elevated expression of bone-related genes.
Review
Biochemistry & Molecular Biology
Batoryna Olgierd, Zyla Kamila, Banys Anna, Morawiec Emilia
Summary: Caffeic acid phenethyl ester (CAPE) is a potent antioxidant derived from honey bee-hive propolis, known for its anti-inflammatory, antiviral, antibacterial, anticancer, immunomodulatory, and wound-healing properties. This review highlights the biological properties and potential therapeutic applications of CAPE in various diseases.
Article
Biochemistry & Molecular Biology
Anna Kleczka, Radoslaw Dzik, Agata Kabala-Dzik
Summary: This study investigated the effects of the combined use of caffeic acid phenethyl ester (CAPE) and paclitaxel (PTX) on ovarian cancer cells. The results showed that low doses of PTX exerted cytotoxic effects against all tested cell lines, and the combined use of CAPE and PTX enhanced the cytotoxicity and anti-migration activity.
Article
Agriculture, Multidisciplinary
Min Ling, Yanfei Xu, Xuan Huang, Changwei He, Zheng Zhou
Summary: In this study, stable nanocomplexes between phosphorylated walnut protein and chitosan were successfully fabricated under acidic pH conditions, which showed promising encapsulation capacity for caffeic acid phenethyl ester (CAPE). The nanocomplexes exhibited stability, high viscosity, good suspensibility, and controlled release of CAPE.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Environmental Sciences
Rili Hao, Junlin Ge, Yongfeng Ren, Xinyu Song, Yang Jiang, Dongxiao Sun-Waterhouse, Feng Li, Dapeng Li
Summary: Cadmium-induced liver damage was significantly reduced by caffeic acid phenethyl ester (CAPE) through multiple pathways, including alleviation of oxidative stress, inhibition of apoptosis, and suppression of inflammation. This study provides novel insights into the treatment of cadmium-related diseases through targeting miR-182-5p/TLR4 axis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Applied
Yongqi Liu, Keke Liu, Xiaolong Wang, Yiwen Shao, Xue Li, Limin Hao, Xuemei Zhang, Juanjuan Yi, Jike Lu
Summary: Asiatic acid-caffeic acid phenethyl ester nanoparticles (ASA-CAPE NPs) were prepared to overcome the limitations of poor solubility, bioavailability, and stability of caffeic acid phenethyl ester (CAPE). The encapsulation and loading efficiencies of ASA-CAPE NPs reached 47.72% and 11.62%, respectively. The nanoparticles exhibited regular spherical morphology, improved water solubility, stability, and bioactivities compared to free CAPE.
Article
Plant Sciences
Tianqiao Yong, Danling Liang, Shaodan Chen, Chun Xiao, Xiong Gao, Qingping Wu, Yizhen Xie, Longhua Huang, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai
Summary: This study demonstrates that caffeic acid phenethyl ester (CAPE) can reduce hyperuricemia by inhibiting xanthine oxidase (XOD) activity and up-regulating organic anion transporter 3 (OAT3), suggesting its potential as a treatment for gout.
Article
Medicine, Research & Experimental
Qian Wu, Junya Li, Shengyu Hao, Yuyang Guo, Zongze Li, Zhengxin Liu, Hongzhuan Xuan
Summary: Glycolysis and lipid metabolism play crucial roles in the growth and metastasis of tumor cells. In this study, caffeic acid phenethyl ester (CAPE) was found to inhibit proliferation, migration, invasion, and angiogenesis of breast cancer cells by modulating inflammatory mediators and inhibiting key proteins and enzymes in glycolysis and lipid metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Seon-Hee Choi, Dong-Yeon Lee, Sohi Kang, Min-Kyung Lee, Jae-Heun Lee, Sang-Heon Lee, Hye-Lim Lee, Hyo-Young Lee, Young-IL Jeong
Summary: In this study, CAPE-incorporated HAsPBPE nanoparticles were successfully synthesized and shown to have radiosensitivity. These nanoparticles effectively prevented radiation-induced cell death and apoptotic cell death, making them promising candidates for the radio-sensitive delivery of CAPE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Km Anjaly, Ashu Bhan Tiku
Summary: In this study, the radiomodulatory potential of caffeic acid phenethyl ester (CAPE) in prostate cancer cells was evaluated. CAPE was found to enhance the sensitivity of prostate cancer cells to radiation and induce apoptosis, while inhibiting cell migration. The combination treatment of CAPE and radiation increased DNA damage and cell death by inhibiting DNA repair proteins. Therefore, CAPE may be a potential adjuvant for the treatment of hormone-refractory radioresistant prostate cancer.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Katya Kamenova, Georgy Grancharov, Vasilena Kortenova, Petar D. Petrov
Summary: We report the preparation of redox-responsive functional micellar nanocarriers for triggered release of CAPE in cancer therapy. The three-layered micelles, composed of PCL core, PAA/PEO middle layer, and PEO outer corona, were assembled by two amphiphilic triblock copolymers. The loaded micelles were crosslinked to enhance structural stability and prevent premature release of CAPE. However, under weak acidic conditions and in the presence of reducing agent, the payload was rapidly released due to the breakup of disulfide linkages. The developed CPMs showed potential for controlled drug release in the tumor microenvironment.
Review
Chemistry, Analytical
Ketki Bagwe, Noah Gould, Kendall R. Johnson, Alexander R. Ivanov
Summary: Tissues and cell populations exhibit high levels of heterogeneity at the cellular level, making it important to analyze smaller sample sizes to capture subtle differences between cells. Capillary electrophoresis coupled with mass spectrometry (CE-MS) is a powerful technique for proteomics and metabolomics analysis at the single-cell level, and this review focuses on its applications and recent advances in sample preparation, separation, MS acquisition, and data analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rasha AlSheikh, Hamad N. Albagieh, Ismail Abdouh, Hattan Zaki, Amal M. Alzahrani, Hassan S. Halawany, Khalifa S. Al-Khalifa
Summary: This in vitro study evaluated the antimicrobial effect of propolis extract caffeic acid phenethyl ester (CAPE) on four different oral microorganisms. The results showed that CAPE had the strongest inhibitory effect on Staphylococcus aureus and the weakest effect on Streptococcus mutans. S. salivarius and S. aureus were the most resistant bacteria to CAPE. These findings suggest that CAPE could be used as an adjunct dental hygiene substance and have potential therapeutic effects in oral health care.
APPLIED SCIENCES-BASEL
(2022)
Article
Immunology
Xiangyu Chen, Guoshuai Cao, Jialin Wu, Xinxin Wang, Zhiwei Pan, Jianbao Gao, Qin Tian, Lifan Xu, Zhirong Li, Yaxing Hao, Qizhao Huang, Pengcheng Wang, Minglu Xiao, Luoyingzi Xie, Shupei Tang, Zhenyu Liu, Li Hu, Jianfang Tang, Ran He, Li Wang, Xinyuan Zhou, Yuzhang Wu, Mengjie Chen, Beicheng Sun, Bo Zhu, Jun Huang, Lilin Ye
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Weiwu Gao, Zhengcai Jia, Yi Tian, Penghui Yang, Hui Sun, Chenhui Wang, Yi Ding, Mengjie Zhang, Yi Zhang, Di Yang, Zhiqiang Tian, Jian Zhou, Zhihua Ruan, Yuzhang Wu, Bing Ni
Article
Biochemical Research Methods
Songlin Zhang, Jian Chen, Peijian Hong, Jinru Li, Yi Tian, Yuzhang Wu, Shufeng Wang
JOURNAL OF IMMUNOLOGICAL METHODS
(2020)
Article
Multidisciplinary Sciences
Li Wang, Jun Tang, Xia Yang, Peter Zanvit, Kairong Cui, Wai Lim Ku, Wenwen Jin, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Bing Ni, Keji Zhao, Yuzhang Wu, WanJun Chen
NATURE COMMUNICATIONS
(2020)
Correction
Immunology
Jintao Li, Ji Zhang, Hongxia Guo, Shimin Yang, Weiping Fan, Nan Ye, Zhiqiang Tian, Tiantian Yu, Guoping Ai, Zigang Shen, Haiyang He, Ping Yan, Hui Lin, Xue Luo, Hongli Li, Yuzhang Wu
FRONTIERS IN IMMUNOLOGY
(2020)
Letter
Immunology
Xiangyu Chen, Ren Li, Zhiwei Pan, Chunfang Qian, Yang Yang, Renrong You, Jing Zhao, Pinghuang Liu, Leiqiong Gao, Zhirong Li, Qizhao Huang, Lifan Xu, Jianfang Tang, Qin Tian, Wei Yao, Li Hu, Xiaofeng Yan, Xinyuan Zhou, Yuzhang Wu, Kai Deng, Zheng Zhang, Zhaohui Qian, Yaokai Chen, Lilin Ye
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Immunology
Huang Huang, Xiaoping Wu, Dongwei Meng, Yizhou Feng, Lan Zhou, Zhenyu Liu, Shupei Tang, Xueqin Li, Yi Cao, Haiyang He, Zhunyi Xie, Jingbo Zhang, Yongwen Chen, Tingting Zhao, Yuzhang Wu, Xinyuan Zhou
Summary: The study demonstrated that LXR beta deficiency leads to a reduction in single-positive (SP) thymocytes and increased apoptosis, indicating the crucial role of LXR beta in promoting the survival of SP thymocytes. The findings also suggest that LXR beta positively regulates the expression of IL-7R alpha in SP thymocytes, which is essential for their survival.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Infectious Diseases
Bo Diao, Kun Wen, Ji Zhang, Jian Chen, Chao Han, Yongwen Chen, Shufeng Wang, Guohong Deng, Hongwei Zhou, Yuzhang Wu
Summary: The FIC assay for NP antigen testing shows high specificity and relatively high sensitivity in early-phase SARS-CoV-2 diagnosis, according to a study conducted in Wuhan and Chongqing between February 10 and 15, 2020.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Endocrinology & Metabolism
Lina Wang, Ping Sun, Yuzhang Wu, Li Wang
Summary: Obesity-induced low-grade chronic inflammation in metabolic tissues is a major factor for various diseases. Tissue-resident macrophages and adaptive CD8(+) T cells play important roles in this process, but further research is needed to understand the mechanisms involved.
Review
Biochemistry & Molecular Biology
Yiwei Zhang, Zhiyuan Wei, Hui Dong, Jian Zhou, Jizhao Yuan, Bing Ni, Yuzhang Wu, Chao Han, Yi Tian
Summary: This review summarizes the role of RNA-binding proteins, microRNAs, and long non-coding RNAs in regulating the fate of Th17 cells, as well as the impact of RNA modifications and nonsense-mediated mRNA decay in Th17 cells. Ongoing research may provide insights into practical applications for regulating mRNA stability in the context of Th17-related autoimmune diseases.
Article
Multidisciplinary Sciences
Yi Tian, Chao Han, Zhiyuan Wei, Hui Dong, Xiaohe Shen, Yiqiang Cui, Xiaolan Fu, Zhiqiang Tian, Shufeng Wang, Jian Zhou, Di Yang, Yi Sun, Jizhao Yuan, Bing Ni, Yuzhang Wu
Summary: This study identified a novel enhancer, RORCE2, for the transcription factor RORγt, which interacts with Sox5 to modulate RORγt expression at the promoter level, providing insights into the regulation of Th17 differentiation and functions.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yiwei Zhang, Jian Zhou, Zhiyuan Wei, Hui Dong, Di Yang, Yuanyu Deng, Jiahui Li, Saiyu Shi, Yi Sun, Huimin Lu, Jizhao Yuan, Bing Ni, Yuzhang Wu, Yi Tian, Chao Han
Summary: Dendritic cells play a crucial role in the immune system by regulating defense against pathogens and tolerance to self. This review highlights the significance of mRNA stability regulation in dendritic cells for their function and immune therapy.
Review
Immunology
Hui Sun, Yuzhang Wu, Yi Zhang, Bing Ni
Summary: This study focuses on the production mechanisms of IL-10 in ILCs, the key role of IL-10 in NK and ILC2 cells, and the potential impact of IL-10-producing ILCs in diseases such as infections, allergies, and cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanyan Zhang, Baohua Li, Qiang Bai, Pengcheng Wang, Gang Wei, Zhirong Li, Li Hu, Qin Tian, Jing Zhou, Qizhao Huang, Zhiming Wang, Shuai Yue, Jialin Wu, Liuqing Yang, Xinyuan Zhou, Lubin Jiang, Ting Ni, Lilin Ye, Yuzhang Wu
Summary: The study identified a key lncRNA-Snhg1 in CD8 T cells that promotes memory formation and inhibits effector cell differentiation. Snhg1 interacts with Vps13D and regulates IL-7 signaling to play a crucial role in memory CD8 cell generation. The Snhg1-Vps13D-IL-7R-TCF1 axis is central in memory CD8 establishment and a potential target for enhancing vaccination effects against ongoing pandemics.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Multidisciplinary Sciences
Xiaoling Chen, Shufeng Wang, Yi Huang, Xia Zhao, Xu Jia, Gang Meng, Qian Zheng, Mengjun Zhang, Yuzhang Wu, Li Wang