Article
Immunology
Dominic D. Skinner, Amber R. Syage, Gema M. Olivarria, Colleen Stone, Bailey Hoglin, Thomas E. Lane
Summary: By characterizing the molecular and cellular changes in transgenic mice, this study reveals the changes in the profile of neutrophils associated with increased white matter damage in mice persistently infected with a neurotropic coronavirus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rachele Di Donato, Raffaella Bonecchi, Francesca Albano
Summary: Chemokines have local functions in controlling leukocyte extravasation and also play additional roles in regulating hematopoiesis and leukocyte differentiation at a systemic level. Atypical chemokine receptors (ACKRs) are regulators of the chemokine system and have a selective role in neutrophil production and differentiation. This review provides an overview of the role of chemokines and chemokine receptors in neutrophil biology with a focus on the regulation exerted by ACKRs.
Review
Gastroenterology & Hepatology
Leanne P. M. van Leeuwen, Wesley de Jong, Laura Doornekamp, Eric C. M. van Gorp, Pieter J. Wismans, Marco Goeijenbier
Summary: Certain exotic viruses can cause clinical diseases with liver involvement. These viruses have various transmission routes and clinical presentations, and they may cause severe liver damage. Timely detection of these exotic hepatitis viruses is crucial.
JOURNAL OF HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Cameron R. Bastow, Mark D. Bunting, Ervin E. Kara, Duncan R. McKenzie, Adriana Caon, Sapna Devi, Lynn Tolley, Scott N. Mueller, Ian H. Frazer, Natasha Harvey, Mark R. Condina, Clifford Young, Peter Hoffmann, Shaun R. McColl, Iain Comerford
Summary: This study reveals the mechanism by which ACKR4 controls DC migration in barrier tissues, identifying the existence of two forms of CCL21 in steady-state conditions and their regulation by ACKR4. It enhances understanding of functional chemokine gradient formation by showing how ACKR4 affects CCL21 gradients in barrier tissues and downstream lymph nodes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Sofia R. Gardeta, Eva M. Garcia-Cuesta, Gianluca D'Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, Jose Miguel Rodriguez-Frade, Mario Mellado
Summary: The local lipid environment plays an important role in regulating CXCR4 organization and function, and modulating chemokine-triggered directed cell migration. Treatment of T cells with bacterial sphingomyelinase alters the lipid composition of the cell membrane, affecting membrane fluidity and CXCR4 nanoclustering and dynamics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Nathan D. Maulding, Spencer Seiler, Alexander Pearson, Nicholas Kreusser, Joshua M. Stuart
Summary: The SARS-CoV-2 pandemic has posed challenges in understanding the health effects caused by the novel infection. Transcriptomic RNA sequencing has provided new insights into viral mechanisms and host responses. The study reveals tissue specificity of SARS-CoV-2 expression, inferred lipopolysaccharide response, and co-regulation with CXCL, SPRR, and S100. These findings have implications for future therapeutic research.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Fenglin Zhao, Xiaoyu Xie, Xu Tan, Hongli Yu, Miaomiao Tian, Huanran Lv, Chengyong Qin, Jianni Qi, Qiang Zhu
Summary: Approximately 250 million people worldwide suffer from chronic Hepatitis B virus infection, leading to significant public health challenges. Despite available vaccines and antiviral drugs, curing chronic hepatitis B remains a distant goal. HBV-encoded proteins, including surface antigen, core antigen, envelope antigen, HBx, and polymerase, play crucial roles in viral persistence and liver pathogenesis, offering potential avenues for new CHB therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Andrea Bonnin Marquez, Emiel P. C. van der Vorst, Sanne L. Maas
Summary: Atherosclerosis is a major cause of cardiovascular diseases, and chemokines and their receptors play a crucial role in its pathophysiological development. Targeting these factors through various methods shows promise in ameliorating atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Edward Dobbs, Greg Deakin, Julie Bennett, Caoimhe Fleming-Archibald, Ian Jones, Helen Grogan, Keny Burton
Summary: The study examined viral interactions in Agaricus bisporus cultures with 9 viruses, identifying four clusters of viral RNA indicating synergism and coreplication. Diseased fruitbodies showed significantly higher levels of specific viral RNA, suggesting an exponential shift in replicative capacity. These interactions appeared to be stochastic, with disease symptoms randomly distributed and high levels of specific viral RNA present.
Article
Multidisciplinary Sciences
Thushan de Silva, Guihai Liu, Benjamin B. Lindsey, Danning Dong, Shona C. Moore, Nienyun Sharon Hsu, Dhruv Shah, Dannielle Wellington, Alexander J. Mentzer, Adrienn Angyal, Rebecca Brown, Matthew D. Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K. Maini, Graham Ogg, Julian C. Knight, Yanchun Peng, Sarah L. Rowland-Jones, Tao Dong
Summary: Variants within dominant SARS-CoV-2 T cell epitopes have been identified through global sequence data analysis. These variants, independently arising in multiple lineages, result in loss of T cell recognition of specific epitopes. The findings demonstrate the potential for T cell evasion and emphasize the importance of ongoing surveillance for variants capable of escaping immune responses.
Review
Immunology
Teizo Yoshimura, Chunning Li, Yuze Wang, Akihiro Matsukawa
Summary: Breast cancer is a common cancer worldwide, and metastasis is the main cause of cancer-related death. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was identified as a chemotactic factor for monocytes, and its role in cancer development and progression was investigated. Studies showed positive correlations between MCP-1 production in tumors and TAM infiltration, as well as cancer progression. MCP-1 was found to promote breast cancer metastasis to the lung and brain, but not bone. The mechanisms of MCP-1 production in the breast cancer microenvironment were also reported.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Soudeh Ghafouri-Fard, Kasra Honarmand, Mohammad Taheri
Summary: Multiple sclerosis (MS) is considered to be a chronic inflammatory disorder of the central nervous system caused by abnormal immune responses. Chemokines play an important role in the pathogenesis of MS, with several members of this family being dysregulated in MS patients' peripheral blood, cerebrospinal fluid, or CNS lesions. Studies in animal models have shown the critical roles of chemokines in the pathophysiology of MS.
METABOLIC BRAIN DISEASE
(2021)
Review
Immunology
Zelin Tian, Chen Xu, Peijun Yang, Zhibin Lin, Wenlong Wu, Wenjie Zhang, Jian Ding, Rui Ding, Xuan Zhang, Kefeng Dou
Summary: Hepatocellular carcinoma (HCC), caused by viral hepatitis, alcoholic, and non-alcoholic fatty liver disease (NAFLD), is the sixth most common cancer worldwide. Viral hepatitis accounts for 80% of HCC cases globally. NAFLD has become the most common liver disease and major risk factor for HCC in developed countries. This review discusses the specific and similar pathogenesis mechanisms of viral hepatitis-induced HCC and NAFLD-induced HCC, including viral proteins, genetic factors, epigenetic modifications, and abnormal lipid metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Mudassier Ahmad, Anupam Dhasmana, Prateek Suresh Harne, Asif Zamir, Bilal Bin Hafeez
Summary: Tumor heterogeneity is a crucial factor in the resistance to chemotherapy and limited efficacy in hepatocellular carcinoma (HCC). Chemokines, a sub-family of cytokines, play a key role in HCC heterogeneity by affecting cell survival, growth, migration, and angiogenesis. Understanding the impact of chemokines on genetic, epigenetic, metabolic, immune cell composition, and tumor microenvironment levels can contribute to the development of personalized medicine strategies for HCC.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Alessio Ardizzone, Rossella Basilotta, Alessia Filippone, Lelio Crupi, Marika Lanza, Sofia Paola Lombardo, Cristina Colarossi, Dorotea Sciacca, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Summary: Primary brain tumors are highly heterogeneous and invasive, leading to high mortality rates worldwide. Current therapies have improved survival rates, but new therapeutic strategies are needed. Immunotherapy approaches, targeting the immunosuppressive microenvironment, have shown promise in CNS tumors. Chemokines, a group of proteins that regulate immune cell recruitment and tumor growth, are examined as potential targets for immunotherapy in primary brain tumors.
Article
Surgery
Barbara Perez-Kohler, Selma Benito-Martinez, Francisca Garcia-Moreno, Marta Rodriguez, Gemma Pascual, Juan Manuel Bellon
Summary: The study investigated the use of cyanoacrylate tissue adhesive to improve mesh behavior at fixation zones. Results showed that cyanoacrylate prevented bacterial adhesion, reducing infections and optimizing the efficacy of antibacterial meshes compared to those fixed with sutures.
Article
Surgery
Gemma Pascual, Selma Benito-Martinez, Marta Rodriguez, Barbara Perez-Kohler, Francisca Garcia-Moreno, Juan M. Bellon
Summary: The behaviour of two composite materials, Phasix and Symbotex, at the peritoneal level during hernia repair was examined in a preclinical model. Phasix showed greater neoperitoneum thickness and higher expression of M2 macrophage markers related to tissue repair compared to Symbotex. The study concluded that fewer adhesions formed to Symbotex implants, yet Phasix had a stronger tissue repair response.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Cell Biology
Julia Pena-Asensio, Henar Calvo, Miguel Torralba, Joaquin Miquel, Eduardo Sanz-de-Villalobos, Juan-Ramon Larrubia
Summary: The challenge in treating non-responsive chronic HCV infection lies in restoring CD8(+) T cell response by overcoming PD-1 effect and enhancing other co-stimulatory mechanisms.
Article
Multidisciplinary Sciences
Coral Garcia-Pastor, Selma Benito-Martinez, Ricardo J. Bosch, Ana B. Fernandez-Martinez, Francisco J. Lucio-Cazana
Summary: Proximal tubular cells (PTC) are vulnerable to hypoxia-induced apoptosis, which may be a crucial factor in kidney diseases. Research has shown that apoptosis under hypoxia is mediated by COX-2-dependent production of PGE(2), suggesting potential new therapeutic targets for preventing hypoxia-dependent lesions in renal diseases.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Julia Pena-Asensio, Henar Calvo, Miguel Torralba, Joaquin Miquel, Eduardo Sanz-de-Villalobos, Juan-Ramon Larrubia
Summary: The cytotoxic T cell response against hepatocellular carcinoma antigens is exhausted, but can be restored by blocking negative immune checkpoints. Combinatory strategies based on anti-PD-1 are being studied to enhance the therapeutic effect.
Article
Biochemistry & Molecular Biology
Samuel Bernardo-Bermejo, Elena Sanchez-Lopez, Lei Tan, Selma Benito-Martinez, Zhengjin Jiang, Maria Castro-Puyana, Francisco Javier Lucio-Cazana, Maria Luisa Marina
Summary: Oxygen deficiency can disrupt biological functions and lead to diseases. Kidneys are particularly sensitive to hypoxia, which is linked to acute kidney injury and chronic kidney disease. Understanding hypoxia-induced metabolic alterations is crucial for kidney disease research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Selma Benito-Martinez, Barbara Perez-Kohler, Marta Rodriguez, Francisca Garcia-Moreno, Veronica Gomez-Gil, Gemma Pascual, Juan Manuel Bellon
Summary: The study suggests that coating meshes with chlorhexidine or rifampicin-carboxymethylcellulose biopolymer gel may help improve abdominal wall tissue repair in the presence of infection following mesh implantation.
Article
Surgery
Selma Benito-Martinez, Marta Rodriguez, Francisca Garcia-Moreno, Barbara Perez-Kohler, Estefania Pena, Begona Calvo, Gemma Pascual, Juan Manuel Bellon
Summary: This study compared the biological and mechanical behavior of two self-fixing meshes to that of a mesh fixed with tissue adhesive in a preclinical model of abdominal hernia repair in rabbits. The results showed that the self-fixing meshes exhibited better host tissue incorporation, macrophage response, and tensile strength compared to the adhesive mesh.
Review
Chemistry, Physical
Barbara Perez-Koehler, Selma Benito-Martinez, Veronica Gomez-Gil, Marta Rodriguez, Gemma Pascual, Juan Manuel Bellon
Summary: Abdominal hernia repair using prosthetic meshes is a common surgical intervention globally. 3D-printing technology has been applied to manufacture bioactive materials for improved hernia repair solutions. However, challenges and limitations still exist, with promising future prospects for development.
Article
Gastroenterology & Hepatology
Julia Pena-Asensio, Henar Calvo, Joaquin Miquel, Eduardo Sanz-de-Villalobos, Alejandro Gonzalez-Praetorius, Miguel Torralba, Juan-Ramon Larrubia
Summary: This study aimed to predict the restoration of HBV-specific CD8(+) cell response during nucleos(t)ide analogue (NUC) treatment and use it as a tool for treatment stopping. Short-term low-level antigen exposure and early long-term NUC treatment were found to influence the restoration of a functional HBV-specific CD8(+) cell response. Based on these predictors, a high likelihood of detecting this response at treatment withdrawal is associated with off-treatment HBV control and HBsAg decline and loss.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Medicine, General & Internal
Francisco Valverde-Lopez, Juan Gabriel Martinez-Cara, Eduardo Redondo-Cerezo
Summary: Acute pancreatitis is a common disease in gastroenterology, with gallstones and alcohol as the main causes. Diagnostic criteria and imaging techniques have been well defined, with ultrasound being useful for diagnosing the cause and computed tomography being better for assessing risk and complications. Fluid therapy, early oral feeding, and pain management are the mainstay of early treatment for acute pancreatitis. Antibiotics are useful when infected necrosis or extra pancreatic infections are present or suspected, but not for prophylaxis in sterile necrotizing pancreatitis. Minimally invasive approaches have emerged for managing walled off necrosis, improving complications rates, quality of life, and hospital stay compared to open surgery.
Article
Biochemistry & Molecular Biology
Selma Benito-Martinez, Barbara Perez-Kohler, Marta Rodriguez, Jesus Maria Izco, Jose Ignacio Recalde, Gemma Pascual
Summary: This preclinical study compared the effects of a new collagen-based hydrolysate powder to a commercial non-hydrolysate product on wound repair in a murine model. The findings indicate that the new collagen treatment can significantly accelerate wound closure and promote the reparative process.
Letter
Gastroenterology & Hepatology
Julia Pena-Asensio, Henar Calvo, Joaquin Miquel, Eduardo Sanz-de-Villalobos, Alejandro Gonzalez-Praetorius, Miguel Torralba, Juan-Ramon Larrubia
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Julia Pena Asensio, Henar Calvo, Joaquin Miquel, Eduardo Sanz de Villalobos, Alejandro Gonzalez Praetorius, Miguel Torralba, Juan Ramon Larrubia
JOURNAL OF HEPATOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Julia Pena Asensio, Henar Calvo, Joaquin Miquel, Eduardo Sanz de Villalobos, Alejandro Gonzalez Praetorius, Miguel Torralba, Juan Ramon Larrubia
JOURNAL OF HEPATOLOGY
(2021)